Resveratrol, Wine, and Atherosclerosis

Prasad, Kailash

doi:10.1055/s-0032-1306417

Cited by 46 publications

(33 citation statements)

References 145 publications

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“…key event in inflammatory processes. Moreover, resveratrol has been shown to be effective in suppressing inflammation [11] and also to inhibit the expression of CAMs [24]. However, the molecular mechanisms underlying the resveratrol-inhibited expression of adhesion molecules in HPAEpiCs remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol inhibitsStaphylococcus aureus-induced TLR2/MyD88/NF-κB-dependent VCAM-1 expression in human lung epithelial cells

et al. 2014

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Staphylococcus aureus is the most commonly found Gram-positive bacterium in patients admitted to intensive-care units, causing septicaemia or pneumonia. S. aureus is considered to play an important role in the induction of cell adhesion molecules. Resveratrol, a compound found in the skins of red fruits, may inhibit the inflammatory signalling pathways involved in lung diseases. In the present paper, we have shown that resveratrol reduced S. aureus-mediated VCAM-1 (vascular cell adhesion molecule-1) expression in HPAEpiCs (human lung epithelial cells) and lungs of mice. In an in vivo study, we have shown that resveratrol inhibited S. aureus-induced pulmonary haematoma and leucocyte count in BAL (bronchoalveolar lavage) fluid in mice. In an in vitro study, we observed that resveratrol attenuated S. aureus-induced TLR2 (Toll-like receptor 2), MyD88 (myeloid differentiation factor 88) and PI3K (phosphoinositide 3-kinase) complex formation. S. aureus stimulated Akt, JNK1/2 (c-Jun N-terminal kinase 1/2) and p42/p44 MAPK (mitogen-activated protein kinase) phosphorylation, which were inhibited by resveratrol. In addition, S. aureus induced IκB (inhibitor of nuclear factor κB) α and NF-κB (nuclear factor κB) p65 phosphorylation and NF-κB p65 translocation, which were reduced by resveratrol. Finally, we found that S. aureus induced NF-κB and p300 complex formation and p300 phosphorylation, which were inhibited by resveratrol. Thus resveratrol functions as a suppressor of S. aureus-induced inflammatory signalling not only by inhibiting VCAM-1 expression, but also by reducing TLR2-MyD88-PI3K complex formation and Akt, JNK1/2, p42/p44 MAPK, p300 and NF-κB activation in HPAEpiCs.

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Section: Discussionmentioning

confidence: 99%

Resveratrol inhibitsStaphylococcus aureus-induced TLR2/MyD88/NF-κB-dependent VCAM-1 expression in human lung epithelial cells

et al. 2014

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“…It has been used in the Indian medical herb named “Darakchasava” from about 4500 years ago and the clinical effects described in the past for “Darakchasava” are the same attributed to RSV today [ 231 ]. RSV was firstly described for its antitumorigenic properties [ 232 ]; it is present especially in grape skin and red wine, but also in peanuts, pistachios, and pine trees [ 233 ]. The interest of the scientific community for RSV derives from the observation that its administration mimics the effects of calorie restriction, a tool widely recognized to prevent the endothelial dysfunction, thereby attenuating atherosclerosis, hypertension, diabetes, and CVDs risk factors and aging-associated diseases in general [ 234 – 236 ].…”

Section: Polyphenols and The No Signalingmentioning

confidence: 99%

Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases

Forte

Conti

Damato

et al. 2016

Oxidative Medicine and Cellular Longevity

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Within the family of endogenous gasotransmitters, nitric oxide (NO) is the smallest gaseous intercellular messenger involved in the modulation of several processes, such as blood flow and platelet aggregation control, essential to maintain vascular homeostasis. NO is produced by nitric oxide synthases (NOS) and its effects are mediated by cGMP-dependent or cGMP-independent mechanisms. Growing evidence suggests a crosstalk between the NO signaling and the occurrence of oxidative stress in the onset and progression of vascular diseases, such as hypertension, heart failure, ischemia, and stroke. For these reasons, NO is considered as an emerging molecular target for developing therapeutic strategies for cardio- and cerebrovascular pathologies. Several natural derived compounds, such as polyphenols, are now proposed as modulators of NO-mediated pathways. The aim of this review is to highlight the experimental evidence on the involvement of nitric oxide in vascular homeostasis focusing on the therapeutic potential of targeting NO with some natural compounds in patients with vascular diseases.

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“…Resveratrol content in certain natural foods (Prasad, 2012 (Howells et al, 2011), by enhancing delivery methods, such as liposomal encapsulation (Narayanan et al, 2009), or by combining it with piperine, a natural product from black pepper (Piper spp.) (Johnson et al, 2011).…”

Section: Tablementioning

confidence: 99%

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Carrizzo

Forte

Damato

et al. 2013

Food and Chemical Toxicology

174

105

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a b s t r a c tResveratrol-a natural polyphenolic compound-was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: (a) the sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and healthrelated use.

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Resveratrol, Wine, and Atherosclerosis

Cited by 46 publications

References 145 publications

Resveratrol inhibitsStaphylococcus aureus-induced TLR2/MyD88/NF-κB-dependent VCAM-1 expression in human lung epithelial cells

Resveratrol inhibitsStaphylococcus aureus-induced TLR2/MyD88/NF-κB-dependent VCAM-1 expression in human lung epithelial cells

Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

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