1962
DOI: 10.1016/0006-3002(62)90228-7
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Resynthesis of cod insulin from its polypeptide chains and the preparation of cod-ox “hybrid” insulins

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1966
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Cited by 66 publications
(15 citation statements)
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“…Substitutions in positions 8, 9 and 10 of the A chain, which account for most of the immunological specificity of the insulin molecule (3)(4)(5)(6)(7), probably explain the lack of sensitivity of radioimmunoassay for chicken insulin in systems where mammalian insulins are used both as the antigen and as the radioactive tracer (8). On the other hand, studies of the biological activity of chicken insulin gave equivocal results.…”
mentioning
confidence: 99%
“…Substitutions in positions 8, 9 and 10 of the A chain, which account for most of the immunological specificity of the insulin molecule (3)(4)(5)(6)(7), probably explain the lack of sensitivity of radioimmunoassay for chicken insulin in systems where mammalian insulins are used both as the antigen and as the radioactive tracer (8). On the other hand, studies of the biological activity of chicken insulin gave equivocal results.…”
mentioning
confidence: 99%
“…It is therefore likely that most of the iodine-labeled insulin used in the experimerits which were presented in this communication, had iodine attached to the tyrosincs at position 14 and/or 19. WILSON, DIxo~ and WA~m, AW [12] have presented evidence that antibodies directed to the A chain determinants are more effective in neutralizing biological insulin activity than antibodies directed to B chain determinants.…”
Section: -H-mentioning
confidence: 99%
“…There has been some conflict in the results. Wilson et al, 3 Meienhofer and Brinkhof,* and Katzen et a1.j all report yields of 10% or less when reduced insulin chains are reoxidized. However, Jiang et a1.6 report yields of 40-50%.…”
mentioning
confidence: 97%