Achieving Food Security (FS) is perhaps our most challenging aspiration. Despite our best efforts, millions of people around the globe are malnourished or live with hunger. The state of the geo-political scene, as well as the COVID-19 pandemic, have recently brought forth fears of a Global Food Crisis (GFC). Here, we present the factors that threaten FS and could trigger a GFC, examine the potential of alternative crops (ACs) as a measure against an upcoming GFC, and highlight the key aspects of the ACs introduction process in new regions. ACs could enhance FS, yet their success is premised on the adoption of sustainable practices and the implementation of food strategies that aim to promote healthy consumer behaviours.