Retention and Excretion of Radionuclides of the Alkali Metals by Five Mammalian Species

Cr, Richmond

doi:10.1097/00004032-198006000-00019

Cited by 25 publications

(28 citation statements)

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“…Parameters of the two-term equation fitted to the fractional retention of '"Cs and biological parameters obtained from data described by Lloyd et al (1973) in individuals with internally deposited burdens of 13'Cs. one obtained in out study with dogs and in other studies (Boecker 1972;Richmond 1980). Data of Lloyd et al (1973) involving healthy subjects with normal creatine phosphokinase were used in our work to complement the results obtained in dogs.…”

Section: Short-term Retention Fraction (Al)mentioning

confidence: 81%

A Biokinetic Model for 137Cs

Melo¹,

Lipsztein²,

Oliveira³

et al. 1997

Health Physics

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An improved biokinetic model for 137Cs in humans was developed based on an analysis of data obtained from individuals internally contaminated during an accident in Goiania, Brazil, and other data. Seventeen children (ten girls and seven boys 1-10 y old), ten adolescents (four females and six males), and thirty adults, (fifteen females and fifteen males contaminated in the accident in Goiânia contributed to this study. 137Cs retention was determined through periodic measurements in a whole-body counter. In addition to the data on 137Cs retention from these individuals, data from a study on the metabolism of 137Cs in immature, adult, and aged Beagle dogs and data from the literature were used in the formulation of the 137Cs biokinetic model presented. Mathematically, the retention of cesium is described by three exponential terms, and the retention model is based on a step function of body weight. When the ICRP Publication 56 model for cesium was compared to the model suggested in this paper, it was determined that the ICRP model predicts lower effective doses in 5-y-old children and higher effective doses in infants, adolescents, and adults.

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Section: Short-term Retention Fraction (Al)mentioning

confidence: 81%

A Biokinetic Model for 137Cs

Melo¹,

Lipsztein²,

Oliveira³

et al. 1997

Health Physics

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“…Nearly identical biokinetics have been found after inhalation, ingestion, intraperitoneal or intravenous administration of 137 Cs in multiple species including mice, rats, dogs, sheep and cattle [summarized in refs. (25, 26)]. It also has been concluded that for homeotherms, the retention and distribution of soluble Cs in vivo is a function of metabolic rate and body size (27).…”

Section: Methodsmentioning

confidence: 99%

Gene Expression Response of Mice after a Single Dose of 137Cs as an Internal Emitter

et al. 2014

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Cesium-137 is a radionuclide of concern in fallout from reactor accidents or nuclear detonations. When ingested or inhaled, it can expose the entire body for an extended period of time, potentially contributing to serious health consequences ranging from acute radiation syndrome to increased cancer risks. To identify changes in gene expression that may be informative for detecting such exposure, and to begin examining the molecular responses involved, we have profiled global gene expression in blood of male C57BL/6 mice injected with 137CsCl. We extracted RNA from the blood of control or 137CsCl-injected mice at 2, 3, 5, 20 or 30 days after exposure. Gene expression was measured using Agilent Whole Mouse Genome Microarrays, and the data was analyzed using BRB-ArrayTools. Between 466–6,213 genes were differentially expressed, depending on the time after 137Cs administration. At early times (2–3 days), the majority of responsive genes were expressed above control levels, while at later times (20–30 days) most responding genes were expressed below control levels. Numerous genes were overexpressed by day 2 or 3, and then underexpressed by day 20 or 30, including many Tp53-regulated genes. The same pattern was seen among significantly enriched gene ontology categories, including those related to nucleotide binding, protein localization and modification, actin and the cytoskeleton, and in the integrin signaling canonical pathway. We compared the expression of several genes three days after 137CsCl injection and three days after an acute external gamma-ray exposure, and found that the internal exposure appeared to produce a more sustained response. Many common radiation-responsive genes are altered by internally administered 137Cs, but the gene expression pattern resulting from continued irradiation at a decreasing dose rate is extremely complex, and appears to involve a late reversal of much of the initial response.

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“…8,15) second components also agreed with the results of previous animal studies using rats (19 and 163 h). 17) In contrast, for 16) Our result 134 Cs administered was cleared at the 134 Cs administered was cleared at the biological half-life of 173 h.…”

Section: Disc Ssionmentioning

confidence: 54%

Gastrointestinal Absorption Rate in Rats for Radiocesium in Soil Collected near Fukushima Power Plant or Doped Artificially with <sup>134</sup>CsCl

Iwata

Takahashi

Tanaka

et al. 2019

Jpn. J. Health Phys.

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The whole-body retention of radiocesium derived from soil was investigated in Wistar strain rats using three types of environmentally contaminated soil containing 134 Cs and 137 Cs collected in Fukushima Prefecture, garden soil doped with 134 CsCl solution, and ionic solutions of 134 CsCl. Approximately 44- 134 Cs and 137 Cs in the three types of soil was cleared exponentially in 12 h, with a half-life of 2.9-7.9 h, and the remaining activity decreased soil, a biphasic retention curve (fast and slow) was observed, because the radioactivity administered was high enough to the rats administered with the 134 gastro-intestinal absorption rate is assumed to be 1.0 for public, is used for the radiocesium in soil, the effective dose may be

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Retention and Excretion of Radionuclides of the Alkali Metals by Five Mammalian Species

Cited by 25 publications

References 0 publications

A Biokinetic Model for 137Cs

A Biokinetic Model for 137Cs

Gene Expression Response of Mice after a Single Dose of 137Cs as an Internal Emitter

Gastrointestinal Absorption Rate in Rats for Radiocesium in Soil Collected near Fukushima Power Plant or Doped Artificially with <sup>134</sup>CsCl

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