Retention and release of oil-in-water emulsions from filled hydrogel beads composed of calcium alginate: impact of emulsifier type and pH

Zeeb, Benjamin; Saberi, Amir Hossein; Weiß, Jochen; McClements, David Julian

doi:10.1039/c4sm02791d

Cited by 91 publications

(57 citation statements)

References 35 publications

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“…Upon contact of alginate droplets with Ca–chloride, insoluble hydrogel microbeads were formed with the extract entrapped in. The microbeads were left in the crosslinking solution for 30 min, washed with Ca–chloride solution to remove unentrapped extract and then used for further analysis (Bugarski and others ; Zeeb and others ). For the sake of clarity, the abbreviations used in further text are:…”

Section: Methodsmentioning

confidence: 99%

Calcium–Alginate–Inulin Microbeads as Carriers for Aqueous Carqueja Extract

Balanč

Kalušević

Drvenica

et al. 2015

Journal of Food Science

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Carqueja (Pterospartum tridentatum) is an endemic species and various bioactive compounds have been identified in its aqueous extract. The aim of this study was to protect the natural antioxidants from the aqueous extract of carqueja by encapsulation in Ca-alginate microbeads and Ca-alginate microbeads containing 10% and 20% (w/v) of inulin. The microbeads produced by electrostatic extrusion technique had an average diameter from 625 μm to 830 μm depending on the portion of inulin. The sphericity factor of the hydrogel microbeads had values between 0.014 and 0.026, while freeze dried microbeads had irregular shape, especially those with no excipient. The reduction in microbeads size after freeze drying process (expressed as shrinkage factor) ranged from 0.338 (alginate microbeads with 20% (w/v) of inulin) to 0.523 (plain alginate microbeads). The expressed radical scavenging activity against ABTS and DPPH radicals was found to be between 30% and 40% for encapsulated extract, while the fresh extract showed around 47% and 57% of radical scavenging activity for ABTS and DPPH radicals, respectively. The correlation between antioxidant activity and the total phenolic content were found to be positive (in both assay methods, DPPH and ABTS), which indicate that the addition of inulin didn't have influence on antioxidant activity. The presence of inulin reduced stiffness of the hydrogel, and protected bead structure from collapse upon freeze-drying. Alginate-inulin beads are envisaged to be used for delivery of aqueous P. tridentatum extract in functional food products.

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Section: Methodsmentioning

confidence: 99%

Calcium–Alginate–Inulin Microbeads as Carriers for Aqueous Carqueja Extract

Balanč

Kalušević

Drvenica

et al. 2015

Journal of Food Science

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“…Oil droplets have been mixed with an aqueous solution of alginate molecules and then injected into a calcium solution [67,68]. When the anionic alginate molecules come into contact with the calcium solution they are cross-linked due to salt bridge formation by the cationic calcium ions.…”

Section: Environment: Embedding Methodsmentioning

confidence: 99%

Extending Emulsion Functionality: Post-Homogenization Modification of Droplet Properties

Bai

McClements

2016

Processes

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Abstract:Homogenizers are commonly used to produce oil-in-water emulsions that consist of emulsifier-coated oil droplets suspended within an aqueous phase. The functional attributes of emulsions are usually controlled by selecting appropriate ingredients (e.g., surfactants, co-surfactants, oils, solvents, and co-solvents) and processing conditions (e.g., homogenizer type and operating conditions). However, the functional attributes of emulsions can also be tailored after homogenization by manipulating their composition, structure, or physical state. The interfacial properties of lipid droplets can be altered using competitive adsorption or coating methods (such as electrostatic deposition). The physical state of oil droplets can be altered by selecting an oil phase that crystallizes after the emulsion has been formed. The composition of the disperse phase can be altered by mixing different kinds of oil droplets together to induce inter-droplet exchange of oil molecules. The local environment of oil droplets can be altered by embedding them within hydrogel beads. The aggregation state of oil droplets can be controlled by promoting flocculation. These post-homogenization methods can be used to alter functional attributes such as physical stability, rheology, optical properties, chemical degradation, retention/release properties, and/or gastrointestinal fate.

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“…In recent years, there has been growing interest in the engineering of multiple emulsions -i.e., multi-phase droplets with internal liquid structure -and their use as templates to synthesize microparticles with complex architectures for various applications including foods, [1][2][3][4] pharmaceuticals, 5-10 cosmetics [11][12][13] and chemical separations. [14][15][16] In particular, using this approach to create multiphasic nanogel particles holds great promise in fields such as drug delivery, 17,18 cataylsis, 19 and photonics.…”

Section: Introductionmentioning

confidence: 99%

“…Solid-state 1 H NMR was used to analyze the oil content of the oil-laden nanogels. For sample preparation, the washed nanogel particles were dispersed in D2O and spun down into a pellet.…”

mentioning

confidence: 99%

Synthesis of Oil-Laden Poly(ethylene glycol) Diacrylate Hydrogel Nanocapsules from Double Nanoemulsions

et al. 2017

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Multiple emulsions have received great interest due to their ability to be used as templates for the production of multi-compartment particles for a variety of applications.However, scaling these complex droplets to nanoscale dimensions has been a challenge due to limitations on their fabrication methods. Here, we report the development of oil-in-water-in-oil (O1/W/O2) double nanoemulsions via a two-step high-energy method, and their use as templates for complex nanogels comprised of inner oil droplets encapsulated within a hydrogel matrix.Using a combination of characterization methods, we determine how the properties of the nanogels are controlled by the size, stability, internal morphology, and chemical composition of the nanoemulsion templates from which they are formed. This allows for identification of 2 compositional and emulsification parameters that can be used to optimize the size and oil encapsulation efficiency of the nanogels. Our templating method produces oil-laden nanogels with high oil encapsulation efficiencies and average diameters of 200-300 nm. In addition, we demonstrate the versatility of the system by varying the types of inner oil, the hydrogel chemistry, the amount of inner oil, and the hydrogel network crosslink density. These non-toxic oil-laden nanogels have potential applications in food, pharmaceutical, and cosmetic formulations.

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Retention and release of oil-in-water emulsions from filled hydrogel beads composed of calcium alginate: impact of emulsifier type and pH

Cited by 91 publications

References 35 publications

Calcium–Alginate–Inulin Microbeads as Carriers for Aqueous Carqueja Extract

Calcium–Alginate–Inulin Microbeads as Carriers for Aqueous Carqueja Extract

Extending Emulsion Functionality: Post-Homogenization Modification of Droplet Properties

Synthesis of Oil-Laden Poly(ethylene glycol) Diacrylate Hydrogel Nanocapsules from Double Nanoemulsions

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