Retention of ferrofluid aggregates at the target site during magnetic drug targeting

Asfer, Mohammed; Saroj, Sunil Kumar; Panigrahi, Pradipta Kumar

doi:10.1016/j.jmmm.2017.04.020

Cited by 15 publications

(7 citation statements)

References 19 publications

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“…Targeted Drug Delivery : There are typically three ways for ferromagnetic particle targeting—passive targeting (based on EPR effect and the size of ferromagnetic particles), active targeting (relying on specially designed targeting ligands), and magnetic focusing (depending on suitable external magnetic field gradient) . After targeting to and accumulating in the tumor area, ferromagnetic particles could release the loading drugs to kill tumor cells.…”

Section: Ferrofluid‐based Detection Diagnosis and Therapymentioning

confidence: 99%

Flexible Ferrofluids: Design and Applications

et al. 2019

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Ferrofluids, also known as ferromagnetic particle suspensions, are materials with an excellent magnetic response, which have attracted increasing interest in both industrial production and scientific research areas. Because of their outstanding features, such as rapid magnetic reaction, flexible flowability, as well as tunable optical and thermal properties, ferrofluids have found applications in various fields, including material science, physics, chemistry, biology, medicine, and engineering. Here, a comprehensive, in‐depth insight into the diverse applications of ferrofluids from material fabrication, droplet manipulation, and biomedicine to energy and machinery is provided. Design of ferrofluid‐related devices, recent developments, as well as present challenges and future prospects are also outlined.

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Section: Ferrofluid‐based Detection Diagnosis and Therapymentioning

confidence: 99%

Flexible Ferrofluids: Design and Applications

et al. 2019

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“…2019), where the jet disintegrates into drops that are then directed by a magnetic field. Moreover, there have been recent biomedical advances in their use in hyperthermia treatment (Zhang, Gu & Wang 2007) and magnetic drug targeting, experimentally (Asfer, Saroj & Panigrahi 2017) and theoretically (Voltairas, Fotiadis & Michalis 2002; Gonella et al. 2020).…”

Section: Introductionmentioning

confidence: 99%

“…In industry, they are most commonly used for dynamic sealing and heat dissipation (Scherer & Figueiredo Neto 2005), and there has been investigation into their use in inkjet printing (Charles 1987;Abdel Fattah, Ghosh & Puri 2016) and three-dimensional printing (Löwa et al 2019), where the jet disintegrates into drops that are then directed by a magnetic field. Moreover, there have been recent biomedical advances in their use in hyperthermia treatment (Zhang, Gu & Wang 2007) and magnetic drug targeting, experimentally (Asfer, Saroj & Panigrahi 2017) and theoretically (Voltairas, Fotiadis & Michalis 2002;Gonella et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Linear stability of a ferrofluid centred around a current-carrying wire

Briggs

Mestel

2022

J. Fluid Mech.

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Investigated first is the linear stability of a Newtonian ferrofluid centred on a rigid wire, surrounded by another ferrofluid with a different magnetic susceptibility. An electric current runs through the wire, generating an azimuthal magnetic field that produces a magnetic stress at the interface of the fluids. Three-dimensional disturbances to the system are considered, and the linearised Navier–Stokes equations are solved analytically in terms of an implicit expression for the growth rate of the disturbance. The growth rate is found numerically for arbitrary Reynolds number, and given explicitly in the inviscid and Stokes regimes. Investigated next is a ferrofluid whose magnetic susceptibility varies radially, centred on a rigid wire, subject to a non-uniform azimuthal field. It is proven that if the gradient of the susceptibility is positive anywhere in the fluid, then the system is linearly unstable. Moreover, it is proven that applying an axial field can stabilise disturbances for both continuous and discontinuous susceptibilities.

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“…Most common are their industrial applications for dynamic sealing and heat dissipation, for example, in audio speakers [4]. Bio-medical applications include magnetic drug targeting, where the FF allows for a localized treatment, and hyperthermia treatment in cancer therapy [5][6][7][8]. Theoretical analysis of FFs is, 2022 The Authors.…”

Section: Introductionmentioning

confidence: 99%

Stability of an inhomogeneous ferrofluid in a channel, subject to a normal field

Briggs

Mestel

2022

Proc. R. Soc. A.

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The stability of a ferrofluid with a fairly arbitrary non-uniform magnetic susceptibility between two parallel walls, subject to a non-uniform magnetic field acting normal to the walls, is investigated. The susceptibility may depend on position and the field strength, and the stationary state is such that the gradient of the susceptibility with respect to the modulus of the field is negative. Previous work suggests that the configuration may be linearly unstable, as regions of higher susceptibility do not coincide with regions of strongest field, and this is proved here. Adding a constant field in the plane of the layer suppresses parallel instabilities, but has no effect on those orthogonal to it. However, it is demonstrated that stability can be achieved by applying a rapidly rotating field.

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Retention of ferrofluid aggregates at the target site during magnetic drug targeting

Cited by 15 publications

References 19 publications

Flexible Ferrofluids: Design and Applications

Flexible Ferrofluids: Design and Applications

Linear stability of a ferrofluid centred around a current-carrying wire

Stability of an inhomogeneous ferrofluid in a channel, subject to a normal field

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