Retention of Leishmania (Leishmania) Mexicana in naturally infected rodents from the State of Campeche, Mexico

Wynsberghe, Nicole R. Van; Canto-Lara, Silvia B.; Damián-Centeno, Alma G; Itzá-Ortíz, Mateo; Andrade-Narvaez, Fernando J.

doi:10.1590/s0074-02762000000500001

Cited by 36 publications

(35 citation statements)

References 21 publications

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“…Parasite demonstration: Based on previous studies in which local signs of infection by L. (L.) mexicana were always located at the base of the tail 10,11,35,36 , smears were made from samples collected at the edge of the lesion (avoiding ulcerated and/or heavily crusted parts) or from the inoculation site in absence of local signs. Moreover, smears were made from the liver and spleen samples.…”

Section: Animalsmentioning

confidence: 99%

“…We have reported in a previous study the retention of L. (L.) mexicana in 29 naturally infected rodents including six P. yucatanicus. These cricetids lived in captivity for up to two years and were tested monthly for the presence of the parasite by cultures of needle aspirates from the base of the tail 35 . These data support the persistence of the parasite in P. yucatanicus experimentally infected, as in the human treated or spontaneously healed and in the mouse model of CL.…”

Section: This Is the First Study That Examines P Yucatanicus Clinicamentioning

confidence: 99%

“…Allen and Chapman, 1897; and Heteromys gaumeri J.A. Allen and Chapman, 1897 10,11,35,36 . The two latter species are endemic in the Yucatan Peninsula.…”

Section: Introductionmentioning

confidence: 99%

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Preliminary study towards a novel experimental model to study localized cutaneous leishmaniasis caused bY Leishmania (Leishmania) mexicana

Sosa-Bibiano

Wynsberghe

Canto-Lara

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThere is not an experimental model of localized cutaneous leishmaniasis (LCL) caused by Leishmania (Leishmania) mexicana. The aim of the present study was to characterize the clinical and histological features of Peromyscus yucatanicus experimentally infected with L. (L.) mexicana. A total of 54 P. yucatanicus (groups of 18) were inoculated with 1x10 6 promastigotes of L. (L.) mexicana in the base of the tail. They were euthanized at three and six months post experimental infection. The control group was inoculated with RPMI-1640. The predominant clinical sign observed was a single ulcerated lesion in 27.77% (5/18) and in 11.11% (2/18) P. yucatanicus at three and six months respectively. The histological pattern described as chronic granulomatous inflammation with or without necrosis was found in 7/7 (100%) biopsies of euthanized P. yucatanicus at three (n = 5) and six (n = 2) months, respectively. These results resembled clinical and histological features caused by L. (L.) mexicana in humans, and support the possibility to employ P. yucatanicus as a novel experimental model to study LCL caused by this parasite.

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Section: Animalsmentioning

confidence: 99%

Section: This Is the First Study That Examines P Yucatanicus Clinicamentioning

confidence: 99%

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Preliminary study towards a novel experimental model to study localized cutaneous leishmaniasis caused bY Leishmania (Leishmania) mexicana

Sosa-Bibiano

Wynsberghe

Canto-Lara

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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“…LC lesions were always located at the base of the tail and four species of cricetids were found infected, of which O. phyllotis and Peromyscus yucatanicus J.H. Allen and Chapman, 1897, were incriminated as primary reservoirs of L. (L.) mexicana in that focus 15,17,43 . Comparisons with other foci were required to better estimate the prevalence of infection with L. (L.) mexicana in small terrestrial rodents and to generalize those results to the whole Yucatan Peninsula.…”

Section: Probably L (L) Mexicana] Was Observed At 40% In Ototylomysmentioning

confidence: 99%

“…In the southern humid forest of the Yucatan Peninsula, transmission of L. (L.) mexicana is limited to the months of November to March, when both high humidity and lower temperatures result in a high abundance of adult sand flies concurrent with the multiplication of parasites in the base of rodent tails 3,17,42,43 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of small mammal prevalence of Leishmania (Leishmania) mexicana in five foci of cutaneous leishmaniasis in the State of Campeche, Mexico

Wynsberghe¹,

Canto-Lara²,

Sosa-Bibiano³

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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sUMMaRyIn the Yucatan Peninsula of Mexico, 95% of the human cases of Cutaneous Leishmaniasis are caused by Leishmania (Leishmania) mexicana with an incidence rate of 5.08 per 100,000 inhabitants. Transmission is limited to the winter months (November to March). One study on wild rodents has incriminated Ototylomys phyllotis and Peromyscus yucatanicus as primary reservoirs of L. (L.) mexicana in the focus of La Libertad, Campeche. In the present study, the prevalence of both infection and disease caused by L. (L.) mexicana in small terrestrial mammals were documented during five transmission seasons (1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004) in five foci of Leishmaniasis in the state of Campeche. Foci separated by only 100 km, with similar relative abundances of small mammals, were found to differ significantly in their prevalence of both symptoms and infection. Transmission rates and reservoir species seemed to change in space as well as in time which limited the implementation of effective control measures of the disease even in a small endemic area such as the south of the Yucatan Peninsula.

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New World Leishmaniasis: The Ecology of Leishmaniasis and the Diversity of Leishmanial Species in Central and South America

Shaw

2002

World Class Parasites

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Retention of Leishmania (Leishmania) Mexicana in naturally infected rodents from the State of Campeche, Mexico

Cited by 36 publications

References 21 publications

Preliminary study towards a novel experimental model to study localized cutaneous leishmaniasis caused bY Leishmania (Leishmania) mexicana

Preliminary study towards a novel experimental model to study localized cutaneous leishmaniasis caused bY Leishmania (Leishmania) mexicana

Comparison of small mammal prevalence of Leishmania (Leishmania) mexicana in five foci of cutaneous leishmaniasis in the State of Campeche, Mexico

New World Leishmaniasis: The Ecology of Leishmaniasis and the Diversity of Leishmanial Species in Central and South America

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