Retention of Supraspinal Delta-like Analgesia and Loss of Morphine Tolerance in δ Opioid Receptor Knockout Mice

Zhu, Yining; King, Michael A.; Schuller, Alwin G.; Nitsche, Joshua F.; Reidl, Maureen; Elde, Robert; Unterwald, Ellen M.; Pasternak, Gavril W.; Pintar, John E.

doi:10.1016/s0896-6273(00)80836-3

Cited by 404 publications

(369 citation statements)

References 34 publications

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“…The pharmacological blockade or ODN-induced downregulation of d receptors diminishes the development of tolerance to and dependence on morphine (Abdelhamid et al, 1991;Miyamoto et al, 1993;Kest et al, 1996;Sánchez-Blázquez et al, 1997). Knockout of the d-opioid receptor gene leads to no analgesic tolerance to morphine in these mice (Zhu et al, 1999). Neither do mice lacking the preproenkephalin gene (that generates the endogenous ligands to the d-opioid receptors) display tolerance to morphine (Nitsche et al, 2002).…”

Section: Discussionmentioning

confidence: 98%

The R7 Subfamily of RGS Proteins Assists Tachyphylaxis and Acute Tolerance at μ-Opioid Receptors

Garzón

López-Fando

Sánchez‐Blázquez

2003

Neuropsychopharmacol

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Section: Discussionmentioning

confidence: 98%

The R7 Subfamily of RGS Proteins Assists Tachyphylaxis and Acute Tolerance at μ-Opioid Receptors

Garzón

López-Fando

Sánchez‐Blázquez

2003

Neuropsychopharmacol

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“…CXBK mice, which express m-opioid receptors at approximately half of the level of C57BL/6 and BALB/c mouse strains, also showed reduced analgesic effects of morphine and the k-selective agonist U50488H (Ikeda et al, 1999;. In contrast, the antinociceptive effects of morphine were not altered in either mice lacking d-opioid receptors (Zhu et al, 1999) or in those lacking k-opioid receptors (Simonin et al, 1998). The present results thus add to the previous suggestions that the m-opioid receptor is an especially key site for the analgesic effects of many opioid ligands.…”

Section: Effects Of Buprenorphine In Mor-ko Micementioning

confidence: 95%

Buprenorphine Antinociception is Abolished, but Naloxone-Sensitive Reward is Retained, in μ-Opioid Receptor Knockout Mice

Ide

Minami

Satoh

et al. 2004

Neuropsychopharmacol

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Buprenorphine is a relatively nonselective opioid receptor partial agonist that is used in the management of both pain and addiction. To improve understanding of the opioid receptor subtypes important for buprenorphine effects, we now report the results of our investigation on the roles of m-, d-, and k-opioid receptors in antinociceptive responses and place preferences induced by buprenorphine. Buprenorphine antinociception, assessed by hot-plate and tail-flick tests, was significantly reduced in heterozygous m-opioid receptor knockout (MOR-KO) mice and abolished in homozygous MOR-KO mice. In contrast, buprenorphine retained its ability to establish a conditioned place preference (CPP) in homozygous MOR-KO, although the magnitude of place preference was reduced as the number of copies of wild-type m-opioid receptor genes was reduced. The remaining CPP of buprenorphine was abolished by pretreatment with the nonselective opioid antagonist naloxone, but only partially blocked by pretreatment with either the d-selective opioid antagonist naltrindole or the k-selective opioid antagonist norbinaltorphimine. These data, and biochemical confirmation of buprenorphine actions as a partial d-, m-, and k-agonist, support the ideas that m-opioid receptors mediate most of analgesic properties of buprenorphine, but that m-and d-and/or k-opioid receptors are each involved in the rewarding effects of this drug.

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“…Knockout of the d-receptor results in a loss of morphine tolerance in mice. 8,9 d-receptor agonists have been found to have analgesic properties, but induce weaker physical dependence. 10,11 In the central nervous system, d-receptor agonists have been shown to modulate m-receptormediated analgesia, suggesting cross-talk between these two kinds of receptors.…”

Section: Introductionmentioning

confidence: 99%

The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk

et al. 2007

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Eleven single-nucleotide polymorphisms (SNPs) spanning OPRD1 were examined in 1063 European Americans (EAs) (620 cases with substance dependence (SD), including 557 with alcohol dependence (AD), 225 with cocaine dependence (CD) and 111 with opioid dependence (OD), and 443 controls). Nominally significant associations (P < 0.05) of five SNPs with SD were observed; only the association of the non-synonymous variant G80T with OD remained significant after correction for multiple testing using SNPSpD. Haplotype analyses with six tag SNPs indicated that a specific haplotype GCAACT, which harbors G80T G-allele and C921T C-allele, was significantly associated with AD (v 2 = 14.82, degrees of freedom (d.f.) = 1, P < 0.001), CD (v 2 = 9.19, d.f. = 1, P = 0.002) and OD (v 2 = 20.68, d.f. = 1, P < 0.001). Logistic regression analyses, with sex and age being considered, demonstrated that this haplotype had a risk effect on AD (P = 0.03, b = 1.86, odds ratio (OR) = 6.43) and especially on OD (P < 0.001, b = 3.92, OR = 50.57). Moreover, seven SNPs covering OPRK1 were examined in the majority of the above subjects (390 cases, including 327 AD, 177 CD and 97 OD subjects, and 358 controls). Although no significant differences in allele, genotype or haplotype frequency distributions were seen between cases and controls, a specific OPRK1 haplotype, GGCTTCT, was significantly associated with AD (v 2 = 8.12, d.f. = 1, P = 0.004). Logistic regression analyses also revealed its risk effect on AD (P = 0.009, b = 1.06, OR = 2.90). Population stratification artifact was not observed in the sample. Taken together, our findings supported a positive association between OPRD1 variants and SD, and a positive haplotypic association between OPRK1 and AD in EAs.

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Retention of Supraspinal Delta-like Analgesia and Loss of Morphine Tolerance in δ Opioid Receptor Knockout Mice

Cited by 404 publications

References 34 publications

The R7 Subfamily of RGS Proteins Assists Tachyphylaxis and Acute Tolerance at μ-Opioid Receptors

The R7 Subfamily of RGS Proteins Assists Tachyphylaxis and Acute Tolerance at μ-Opioid Receptors

Buprenorphine Antinociception is Abolished, but Naloxone-Sensitive Reward is Retained, in μ-Opioid Receptor Knockout Mice

The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk

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