Retention profile and chromatographic separation of Y3+ from Sr2+ by Chelex-100 (cation ion exchanger) physically immobilized with ammonium ion

Abstract

Y 3? retention from aqueous media onto Chelex-100 sorbent impregnated with ammonium nitrate was studied. Y 3? uptake was rapid, reached maximum within 40 min and followed pseudo first order equation. Modified Chelex100 sorbent was successfully packed in column for separation of 90 Y from its parent 90 Sr. The method was based upon retention of Y 3? at pH 1.0 onto sorbent packed column in aqueous diethylenetriaminepentaacetic acid (DTPA). Y 3? species were recovered with HNO 3 and analyzed. The radiochemical and radionuclide purity of 90 Y in the eluate were ascertained. The method is low cost and provides rapid approach for separation of Y 3? from Sr 2? .

Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

“…Thus, the rate-controlling step for Y 3+ sorption by the sorbent is not only gel diffusion control as in the ion exchangers [ 49 , 50 ]. At the initial stage of shaking time, the plot of % E of Y 3+ versus log time was fast and linear approving the occurrence of intraparticle diffusion [ 10 , 50 ]. Thus, a 60 min shaking time was adopted in the following study.…”

“…A Geiger–Muller ( β − Counter) and window detector and a Scaler Ratementer SR7 ( γ -Scintillation Counter) were used for ordinary gamma ray counter and it is fixed with well NaI (Tl) crystal. A high purity germanium (HPGe) coupled to a calibrated multichannel gamma analyzer (Silena, Milan, Italy) was employed to test impurities in the irradiated Y 2 O 3 and SrCO 3 as reported earlier [ 10 ]. The activity of 90 Sr activity was monitored as reported [ 10 ].…”

“…The test solution of 89 SrCl 2 and 90 YCl 3 was heated to dryness and redissolved in deionized water (100 mL) to achieve the final concentrations of 89 SrCl 2 (1.323 × 10 −2 M) and 90 YCl 3 (1.771 × 10 −2 M), respectively. In the irradiated product, the impurities were then checked as reported earlier [ 10 ]. The specific activity ( S ) was then computed as reported earlier [ 40 – 42 ].…”

“…With this background in mind, taking into account the importance of highly pure 90 Y 3+ , the characteristics of the chelating group iminodiacetate moieties of the Chelex-100 anion ion exchanger and some of the synthesized inorganic sorbents as ideal and ecofriendly solid sorbents and in continuation to our previous study [ 10 , 38 – 43 ], the current study is aimed to (i) revising the sorption profiles of Y 3+ and Sr 2+ onto the anion ion exchanger as a new candidate solid sorbent, (ii) establishing a simple and low cost and selective chromatographic separation of 90 Y from its parent 90 Sr by chelating Chelex-100 (anion ion exchanger) sorbent packed column and finally, and (iii) testing the reusability of the established chelating Chelex-100 sorbent packed column towards separation of Y 3+ from its parent Sr 2+ species in aqueous solutions. These results are supportive to recognize the analytical utility of the Chelex-100 in nuclear medicine, waste management and to properly assign the physicochemical behavior of radionuclide 90 Y 3+ and 90 Sr 2+ .…”

“…The United States-food and drug administration (US-FDA) has accepted Zevalin drug that incorporates 90 Y [ 7 , 8 ]. So, it is essential to the 90 Sr impurity in 90 Y samples owing to the radiotoxicity of 90 Sr [ 9 , 10 ]. 90 Y decays to the stable 90 Zr daughter, thus it is used as a pure β -emitter.…”