Retentionsindices zur gaschromatographischen Identifizierung von Arzneimitteln

Abstract

The use of the Kovats retention indices for standardization in gas chromatography enables the compilation of gaschromatographic data and the exchange of those data between different laboratories. Factors important for reliable determination of the retention indices, in particular the temperature dependence, are discussed. The gain in information due to the application of the retention indices and their differences on two stationary phases is demonstrated by means of tables with indication of their efficiency in searching for unknown compounds from such files. In the supplement retention indices on OV-1, OV-17 and their differences for 72 compounds frequently encountered in toxicological analyses are given.

Modern screening strategies in analytical toxicology with special regard to new benzodiazepines

“…The interlaboratory standard deviation of the RI is in the order of 15-20 RI units (Moffat [38]; Berninger and M611er [7]. According to D F G [18], a "search window" of + 50-60 RI units should be taken into consideration when working under temperature-programmed conditions with an almost linear relationship between the carbon number of the n-alkanes and the retention time (Peel and Perrigo [43,44]).…”

Ein modernes Informationssystem f�r die toxikologische Analytik auf der Basis des (IV+V)-Systems

“…Die Dokumentation von Literaturstellen ist im Gegensatz zur sp~iter zu besprechenden Faktendokumentation wesentlich einfacher, da jedem Zitat eine eindeutige Kennung und damit eine unverwechselbare Fundstelle zugeordnet werden kann. [4], zum Teil in Zusammenarbeit mit M611er [12], in neuerer Zeit Daldrup et al [13], Sachs [14] sowie Maier und Derksen [3].…”