Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model

Zhou, Chunhua; Kong, Dezhi; Zhu, Xiaodong; Wu, Wei; Xue, Rong; Li, Gongying; Xu, Yong; Li, Sha; Tian, Hongjun; Zhuo, Chuanjun

doi:10.3389/fnins.2020.00115

Cited by 15 publications

(8 citation statements)

References 59 publications

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“…In the current study previous suicide attempts had an impact on the Calgary scores. This was also reported by Zhou et al 11 who found that lifetime suicide is common among hospitalized patients with schizophrenia living in agricultural areas of China.…”

Section: Screening For Depression Among Schizophrenia Patients Discussionsupporting

confidence: 79%

Screening for Depression among Schizophrenia Patients: A Cross-sectional Study

Al-Ruwais¹,

AlHarbi²,

Abalkhail³

et al. 2021

Eastern Journal of Psychiatry

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Section: Screening For Depression Among Schizophrenia Patients Discussionsupporting

confidence: 79%

Screening for Depression among Schizophrenia Patients: A Cross-sectional Study

Al-Ruwais¹,

AlHarbi²,

Abalkhail³

et al. 2021

Eastern Journal of Psychiatry

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“…Data were compared using one-way analysis of variance and post hoc Tukey tests. Data analysis and figure plotting were performed with the GraphPad Prism software (version 8.0) [ 65 , 66 ]. No animals were excluded from the present study.…”

Section: Methodsmentioning

confidence: 99%

Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study

et al. 2021

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Brain pathological features during manic/hypomanic and depressive episodes in the same patients with bipolar disorder (BPD) have not been described precisely. The study aimed to investigate depressive and manic-phase-specific brain neural activity patterns of BPD in the same murine model to provide information guiding investigation of the mechanism of phase switching and tailored prevention and treatment for patients with BPD. In vivo two-photon imaging was used to observe brain activity alterations in the depressive and manic phases in the same murine model of BPD. Two-photon imaging showed significantly reduced Ca2+ activity in temporal cortex pyramidal neurons in the depression phase in mice exposed to chronic unpredictable mild stress (CUMS), but not in the manic phase in mice exposed to CUMS and ketamine. Total integrated calcium values correlated significantly with immobility times. Brain Ca2+ hypoactivity was observed in the depression and manic phases in the same mice exposed to CUMS and ketamine relative to naïve controls. The novel object recognition preference ratio correlated negatively with the immobility time in the depression phase and the total distance traveled in the manic phase. With recognition of its limitations, this study revealed brain neural activity impairment indicating that intrinsic emotional network disturbance is a mechanism of BPD and that brain neural activity is associated with cognitive impairment in the depressive and manic phases of this disorder. These findings are consistent with those from macro-imaging studies of patients with BPD. The observed correlation of brain neural activity with the severity of depressive, but not manic, symptoms need to be investigated further.

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“…We recently modeled coexistent schizophrenia and depression by exposing mice to chronic unpredictable mild stress (CUMS) after receiving 10-day exposures to MK801. Behavioral assays showed higher despair, anhedonia and deficits of prepulse inhibition (PPI) (Zhou et al, 2020). This model of schizophrenia with comorbid depression thus provides a valuable tool for in vivo drug evaluation.…”

Section: Introductionmentioning

confidence: 94%

Metformin Enhances Antidepressant/Antipsychotic Combination Therapy of Schizophrenia With Comorbid Depression in a Murine Model

et al. 2020

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Comorbid depressive disorders confound the diagnosis and therapy of schizophrenia. Using a murine model incorporating both MK801 and chronic unpredictable mild stress exposures, we successfully replicated both psychosis and depression. Ex vivo patch clamp recordings and in vivo calcium imaging demonstrated impaired neural activity in the prefrontal cortex (PFC). We then administered triple-drug combinations consisting of two antidepressants (mirtazapine and venlafaxine) plus an antipsychotic (either clozapine or olanzapine), and found improved PFC neuronal activity and performance in behavioral assays. Moreover, the addition of metformin to both psychotropic drug combinations brought further improvements in depressive and schizophrenic-like behaviors and physiological parameters. In summary, our data modeled the neuropathophysiology of schizophrenia with comorbid depression, and may inform drug intervention strategies.

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Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model

Cited by 15 publications

References 59 publications

Screening for Depression among Schizophrenia Patients: A Cross-sectional Study

Screening for Depression among Schizophrenia Patients: A Cross-sectional Study

Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study

Metformin Enhances Antidepressant/Antipsychotic Combination Therapy of Schizophrenia With Comorbid Depression in a Murine Model

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