Rethinking the Intrinsic Sensitivity of Fungi to Glyphosate

Tall, Tuomas; Puigbò, Pere

doi:10.3390/biotech11030028

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Regarding glyphosate, it seems obvious how it can impact the microbiota since it inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSP synthase) in plants, hampering the production of aromatic amino acids [ 40 ]. This enzyme, essential for cellular survival in some organisms, is also found in bacteria, archaea, and fungi but is absent in humans, meaning that glyphosate could disrupt the balance of intestinal microorganisms and promote the growth of pathogens [ 41 , 42 ]. Meanwhile, diquat and imidacloprid, among other pesticides, have the potential to disturb the integrity of tight junctions in the epithelium, causing a disruption in cell cohesion and compromising the permeability of the intestinal barrier [ 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Exposure to Environmental Pesticides and the Risk of Autism Spectrum Disorders: A Population-Based Case-Control Study

Román,

Ruiz-González,

Rueda-Ruzafa

et al. 2024

Medicina

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Background and Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by challenges in communication, social interactions, and repetitive behaviors. Although the factors that influence the development of this condition are unknown, certain chemical compounds such as pesticides have been proposed as possible contributors. Due to the lack of an established causal link between pesticide exposure and ASD, this study aimed to evaluate this potential association. Materials and Methods: A case-control study was carried out to ascertain the prevalence and risk associated with ASD in relation to pesticide exposure over a 21-year study period (2000–2021). Results: We included 2821 individuals diagnosed with ASD residing in areas of both high and low pesticide exposure in southern Spain. There was a rise in the ASD prevalence rate in regions with elevated pesticide use when compared to regions with low use [odds ratio (OR): 1.34, 95% confidence interval (CI), (1.24–1.44)]. Notably, men had the highest likelihood, with an OR: 1.42, 95% CI, (1.30–1.55). Furthermore, after performing multiple binary logistic regression adjusted for age, sex, and geographical area, males exhibited a higher likelihood compared to females [OR: 2.41, 95% CI, (2.21–2.62)]. Conclusions: Overall, this research suggests a connection between heightened environmental pesticide exposure due to increased agricultural use and autism.

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Section: Introductionmentioning

confidence: 99%

Exposure to Environmental Pesticides and the Risk of Autism Spectrum Disorders: A Population-Based Case-Control Study

Román,

Ruiz-González,

Rueda-Ruzafa

et al. 2024

Medicina

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Functional characterization of novel mutations in the conserved region of EPSPS for herbicide resistance in pigeonpea: structure-based coherent design

Bharti,

Verma,

Gupta

et al. 2023

Journal of Biomolecular Structure and Dynamics

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Glyphosate Residues in Soil and Phosphate Fertilizer Affect Foliar Endophytic Microbial Community Composition and Phytohormone Levels in Potato

Mathew,

Jeevannavar,

Helander

et al. 2024

Phytobiomes Journal

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Glyphosate, the active ingredient of glyphosate-based herbicide (GBH) controls the growth of weeds by inhibiting shikimate pathway, thereby interrupting amino acid biosynthesis in plants. However, several microbes have shikimate pathway and the action of glyphosate on these non-target organisms are ignored. Along with other agrochemicals such as phosphate fertilizers, the action of GBH is further complicated, often varying their mode of action depending on soil type or plant species. To address the impact of GBH and phosphate fertilizer, we simulated agricultural application of GBH and phosphate fertilizer in a field study, investigating the composition of endophytic microbial communities and correlation of phytohormone concentrations with the microbial diversity of potato (Solanum tuberosum). In leaves, glyphosate residues in soil from GBH treatment alone and in combination with phosphate significantly shifted bacterial community whereas phosphate alone and in combination with glyphosate significantly altered the composition of fungal community. There were no significant changes in microbial communities in roots and tubers. Plants treated with GBH showed higher ratios of potentially glyphosate-resistant bacteria, with Xanthomonadaceae and Moraxallaceae being more abundant. Additionally, phytohormone concentrations showed various correlations with bacterial and fungal diversity in different treatments. The study highlights the impact of GBH residues in soil, particularly in combination with phosphate fertilizers on the composition of plant-associated microbial communities. Together with changes in phytohormone concentrations, plant health may be affected. Moreover, future studies could provide insights to whether these agrochemicals influence plant microbiome, leading to changes in phytohormones or vice-versa.

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Rethinking the Intrinsic Sensitivity of Fungi to Glyphosate

Cited by 4 publications

References 30 publications

Exposure to Environmental Pesticides and the Risk of Autism Spectrum Disorders: A Population-Based Case-Control Study

Exposure to Environmental Pesticides and the Risk of Autism Spectrum Disorders: A Population-Based Case-Control Study

Functional characterization of novel mutations in the conserved region of EPSPS for herbicide resistance in pigeonpea: structure-based coherent design

Glyphosate Residues in Soil and Phosphate Fertilizer Affect Foliar Endophytic Microbial Community Composition and Phytohormone Levels in Potato

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