Rethinking treatment paradigms: Neoadjuvant therapy and de-escalation strategies in HPV-positive head and neck cancer

Bouassaly, Jenna; Karimi, Naser; Kowalski, Luiz Paulo; Sultanem, Khalil; Alaoui-Jamali, Moulay; Mlynarek, Alex; Mascarella, Marco; Hier, Michael; Sadeghi, Nader; da Silva, Sabrina Daniela

doi:10.1016/j.critrevonc.2024.104326

Critical Reviews in Oncology/Hematology

2024

DOI: 10.1016/j.critrevonc.2024.104326

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Rethinking treatment paradigms: Neoadjuvant therapy and de-escalation strategies in HPV-positive head and neck cancer

Jenna Bouassaly,

Naser Karimi,

Luiz Paulo Kowalski

et al.

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De-escalated Therapy for HPV Positive Oropharyngeal Cancer

Jung,

Kim

2024

Korean J Head Neck Oncol

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Human papillomavirus-positive (HPV+) oropharyngeal cancer has a significantly better prognosis compared to HPV-negative cases, leading to a growing interest in de-escalation strategies that reduce treatment intensity without compromising oncologic outcomes. The potential for de-escalation in the treatment of HPV+ oropharyngeal cancer extends not only to radiation therapy but also to surgical interventions. This involves reducing the extent of surgery through minimally invasive techniques and minimizing the necessity or dosage of radiation therapy by employing neoadjuvant chemotherapy prior to surgery. De-escalated surgical approaches, which include minimized surgical fields, minimally invasive procedures, and the use of neoadjuvant chemotherapy, may effectively preserve oncologic control while improving patients' quality of life. However, careful patient selection and long-term outcome data are critical for optimizing these strategies.

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De-escalated Therapy for HPV Positive Oropharyngeal Cancer

Jung,

Kim

2024

Korean J Head Neck Oncol

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Rethinking treatment paradigms: Neoadjuvant therapy and de-escalation strategies in HPV-positive head and neck cancer

Cited by 1 publication

References 77 publications

De-escalated Therapy for HPV Positive Oropharyngeal Cancer

De-escalated Therapy for HPV Positive Oropharyngeal Cancer

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