Reticulocyte hemoglobin content as a function of iron stores at 35–36 weeks post menstrual age in very premature infants

Amin, Kanhai; Bansal, Meenakshi; Varley, Nonie; Wang, Hongyue; Amin, Sanjiv B.

doi:10.1080/14767058.2019.1680631

Cited by 8 publications

(3 citation statements)

References 31 publications

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“…The spearman correlation coefficient between SF and Ret-He was 0.23, indicating a weak positive relationship between the two metrics. Our findings align with Amin et al’s study, which also reported a correlation coefficient of 0.21 in similar pediatric cohorts ( 12 ). This weak positive relationship may be related to Ret-He and SF reflecting different stages of ID.…”

Section: Discussionsupporting

confidence: 93%

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Accuracy of reticulocyte hemoglobin for diagnosing iron deficiency in former very preterm infants: a population-based cohort study

Barr,

Kulkarni,

Singh

et al. 2023

Front. Pediatr.

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BackgroundSerum ferritin (SF) is commonly used to diagnose iron deficiency (ID) but has limitations. Reticulocyte hemoglobin (Ret-He) is being increasingly used for ID diagnosis. This study aimed to assess accuracy of Ret-He for ID diagnosis in former very preterm infants (VPI) at 4–6 months corrected age (CA).MethodsA retrospective population-based cohort study was conducted on all live VPI born between 23 and 30 weeks of gestational age (GA) in Nova Scotia from 2012 to 2018. Infants underwent SF and Ret-He testing at 4–6 months CA. ID was defined using two definitions. The first defined ID as SF < 20 mcg/L at both 4- and 6-months CA, and the second as SF < 30 mcg at at both 4- and 6-months CA. The accuracy of Ret-He for identifying ID was assessed using the area under the receiver operating characteristic curve (AUC).ResultsID was present in 39.7% (62) of 156 infants in the first definition and 59.6% (93) in the second at 4–6 months CA. The AUC of Ret-He for ID diagnosis was 0.64 (p = 0.002) in the first definition and 0.59 (p = 0.04) in the second. The optimal cut-off was 29.4pg in the first and 29.7 in the second definition. The sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPV) at the 29.4 pg cut-off were 50.0%, 78.7%, 60.8%, and 70.5% for definition 1 and 44.1%, 74.6%, 71.9%, and 47.5% at the 29.7pg cut-off for definition 2.ConclusionRet-He had low diagnostic accuracy for ID diagnosis in former VPI. Caution is advised when using Ret-He alone for ID diagnosis. Further research is needed to establish optimal approaches for identifying ID in VPI.

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Section: Discussionsupporting

confidence: 93%

“…The above reasons have led to the increased use of Ret-He for diagnosing ID in several pediatric populations (9)(10)(11). It is also increasingly reported in preterm infants during the first few weeks of life (11,12). However, there is a lack of literature on use of Ret-He as a reliable ID marker in preterm infants during the first year of life.…”

mentioning

confidence: 99%

Accuracy of reticulocyte hemoglobin for diagnosing iron deficiency in former very preterm infants: a population-based cohort study

Barr,

Kulkarni,

Singh

et al. 2023

Front. Pediatr.

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“…45 However, like ferritin, limited data validate RET-He as a marker of iron status in preterm neonates. [45][46][47][48] Ishikawa et al reported that healthy adults in Japan had urine ferritin levels about 5% of their serum ferritin levels, with a correlation coefficient of 0.79. 49 On that basis, we speculated that measuring urinary ferritin might be a useful non-invasive way to screen NICU patients for iron deficiency.…”

Section: Developing Practical Ways To Identify Neonatal Iron Deficiencymentioning

confidence: 99%

Iron Deficiency in Newborn Infants: Global Rewards for Recognizing and Treating This Silent Malady

Christensen¹,

Bahr²

2022

Newborn

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Iron deficiency can exist at birth. Even if iron is sufficient at birth, deficiency can develop during the neonatal period, or during infancy, or during childhood. Iron deficiency can exist despite a normal hematocrit and a normal blood hemoglobin concentration, because anemia is a very late manifestation of iron deficiency. It is likely that adverse neurodevelopmental consequences occur during perinatal biochemical iron deficiency, despite a normal hematocrit and hemoglobin. Consequently, measuring those parameters is a very insensitive method for perinatal iron deficiency screening. This review focuses on potentially better practices for diagnosing perinatal iron deficiency, including recent advances in understanding the pathogenesis of this condition, and also on practical means of treatment, and on global rewards of so doing.

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Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency

Bahr

Carr

Christensen

et al. 2021

Blood Cells, Molecules, and Diseases

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Reticulocyte hemoglobin content as a function of iron stores at 35–36 weeks post menstrual age in very premature infants

Cited by 8 publications

References 31 publications

Accuracy of reticulocyte hemoglobin for diagnosing iron deficiency in former very preterm infants: a population-based cohort study

Accuracy of reticulocyte hemoglobin for diagnosing iron deficiency in former very preterm infants: a population-based cohort study

Iron Deficiency in Newborn Infants: Global Rewards for Recognizing and Treating This Silent Malady

Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency

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