Reticulohistiocytic Granulomas of the Skin Associated with Arthritis Mutilans

Johnson, Harold M.; Tilden, I. L.

doi:10.1001/archderm.1957.01550150093014

Cited by 21 publications

(4 citation statements)

References 10 publications

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“…In contrast to the above categories of hypercholesterolaemic bone and joint lesions, the joint damage in reticulohistiocytosis recently reviewed by Warin and others (1957) and by Johnson and Tilden (1957) may be much more severe, leading to arthritis mutilans or main-en-lorgnette (Warin and others, 1957;Johnson and Tilden, 1957) and apparently indistinguishable even in the earlier stages from rheumatoid arthritis. A few of hand x rays have been published, but the reproduction is poor; no record of the earlier stage has been found apart from very minor changes illustrated by Caro and Senear (1952).…”

Section: Discussionmentioning

confidence: 98%

“…Fifthly, excellent descriptions have recently been published (Warin, Evans, Hewitt, Taylor, Price, and Middlemiss, 1957;Johnson and Tilden, 1957) of a deforming erosive type of rheumatism with absorption of articular bone ends associated with an infiltration of lipoprotein-containing cells but with no lipoid deposition or hypercholesterolaemia: twelve previously published cases of "reticulohistiocytosis" are cited most of them with joint symptoms. Finally, the bone changes of another metabolic disorder-Gaucher's disease-may simulate osteomyelitis and by collapse of subchondral bone lead to degenerative joint changes and severe osteoarthritic symptoms.…”

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confidence: 99%

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Histiocytic Bone and Joint Disease

Ansell¹,

Bywaters²

1957

Annals of the Rheumatic Diseases

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Histiocytic Bone and Joint Disease

Ansell¹,

Bywaters²

1957

Annals of the Rheumatic Diseases

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“…Among the several names used in reference to the disease, the following stand out: nondiabetic cutaneous xanthomatosis, 1 lipoid rheumatism, 2 normocholesteremic xanthomatosis, 3 reticulohistiocytoma, 4–12 multiple skin reticulohistiocytomas with destructive arthritis, 13 reticulomatosis with giant histiocytic cells, 14 reticulohistiocytic granuloma, 15–17 lipoid dermatoarthritis, 18–23 giant‐cell reticulohistiocytosis, 24,25 reticulohistiocytosis with giant cells, 26 giant‐cell histiocytomatosis, 27 giant‐cell histiocytosis, 28 and reticulohistiocytosis 29–32 …”

Section: Definition and Synonymsmentioning

confidence: 99%

Multicentric Reticulohistiocytosis: A Proliferation of Macrophages With Tropism for Skin and Joints, Part I

Luz

Gaspar

et al. 2007

Skinmed

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The authors present part I of a review of multicentric reticulohistiocytosis, a rare systemic proliferative disease of histiocytes of unknown cause. It is clinically characterized by cutaneous and mucosal nodules and by osteoarticular lesions. The disease occurs in outbreaks that progress in severity, with spontaneous regression, but usually leaving incapacitating arthritis and disfiguring facial lesions. The authors discuss the historical, epidemiologic, and clinical aspects of this disease.

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“…Although Barrow The cause of MR remains an enigma. Various views about the pathogenesis of MR have been described (5,6,8,9,(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32), but none are conclusive.…”

Section: Electron Microscopic Studiesmentioning

confidence: 99%

A Study of Multicentric Reticulohistiocytosis (Lipoid Dermatoarthritis)

Ikezawa

Nakajima

1976

The Journal of Dermatology

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A case of multicentric reticulohistiocytosis is presented, with typical clinical, roentgenologic, and histologic features. The characteristic giant cells were seen in skin nodules, mucosal nodules, synovial and bony lesions of the joints, and tenosynovial cysts. Corticosteroid therapy produced a subjective improvement, but the arthritis mutilans did not improve. Laboratory studies showed iron‐deficiency anemia, hypertriglyceridemia (hyperprebetalipo‐proteinemia), a low response to the unstimulated and stimulated nitroblue tetrazolium test of neutrophils, and a decreased activity in the glucose‐6‐phosphate dehydrogenase of polimorphonuclear leucocytes before corticosteroid therapy. The histochemical examination of the material in the giant cells showed a lipid (a phospholipid and a neutral fat), and a polysaccharide attached to a protein (a muco‐ or glycoprotein). Electron microscopic studies of the giant cells indicated that their cytoplasm contained numerous dense granules clustered in the vicinity of the Golgi apparatus. In some areas the granules appeared to be developing from the Golgi vesicles and cisternas. It seemed likely that the storage material was produced within the giant cells. We also discussed the pathogenesis of this disorder.

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Reticulohistiocytic Granulomas of the Skin Associated with Arthritis Mutilans

Cited by 21 publications

References 10 publications

Histiocytic Bone and Joint Disease

Histiocytic Bone and Joint Disease

Multicentric Reticulohistiocytosis: A Proliferation of Macrophages With Tropism for Skin and Joints, Part I

A Study of Multicentric Reticulohistiocytosis (Lipoid Dermatoarthritis)

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