Retiform uterine tumours resembling ovarian sex cord tumours. A comparative immunohistochemical study with retiform structures of the female genital tract

Nogales, Francisco F.; Stolnicu, Simona; Harilal, K. R.; Mooney, Eoghan E.; García-Galvis, Olga F.

doi:10.1111/j.1365-2559.2009.03244.x

Cited by 29 publications

(44 citation statements)

References 14 publications

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“…Sir : We read with interest the study of retiform uterine tumour resembling ovarian sex‐cord tumour (UTROSCT) by Nogales et al. 1 in a recent issue of Histopathology . Surprisingly for us, myoid differentiation was not found in these tumours by the authors and they compared the immunophenotype of the tumours to that of mesonephric remnants.…”

mentioning

confidence: 99%

Smooth muscle/myoid differentiation in uterine tumour resembling ovarian sex‐cord tumour (UTROSCT)

Zámečnı́k

Stanik²,

Michal

2009

Histopathology

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confidence: 99%

Smooth muscle/myoid differentiation in uterine tumour resembling ovarian sex‐cord tumour (UTROSCT)

Zámečnı́k

Stanik²,

Michal

2009

Histopathology

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“…Endometriod carcinomas can be differentiated from UTROSCT on microscopic examination because the retiform spaces of this malignancy are characterized by mitoses and nuclear atypia, and these do not show immunoreactivity for sex cord markers, but diffuse positivity for epithelial markers such as EMA and cytokeratin 7 (34). Uterine mesonephric carcinoma is a very rare neoplasm described in the uterine corpus only twice, by Ordi et al (35) and by Bague´et al (36).…”

Section: Clinicopathologic Features Of Utrosctmentioning

confidence: 96%

Clinicopathologic Features of 2 New Cases of Uterine Tumors Resembling Ovarian Sex Cord Tumors

Giordano

Lombardi²,

Brigati³

et al. 2010

International Journal of Gynecological Pathology

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Uterine neoplasms showing an exclusive sex cord-like differentiation or focal low-grade sarcoma differentiation, designated as uterine tumors resembling ovarian sex cord tumors (UTROSCTs), are rare, with only 48 cases described earlier in international literature. Generally, this entity is characterized by benign behavior. In this study, we report the clinical and pathologic features of 2 peculiar new cases of UTROSCTs. In these examples, the pathologic diagnosis of UTROSCT was made incidentally after the clinical diagnosis of a leiomyoma and endometrial polyp. On examination of small biopsies, the diagnosis was facilitated by specific immunohistochemical analysis using markers for the sex cord component. In 1 of these cases, the patient, because of her young age and her desire to preserve her fertility, was only treated by minimally invasive hysteroscopic surgery. In the other case, the neoplasm seemed to be the consequence of tamoxifen treatment for breast carcinoma. After diagnosis, in this second case, the woman underwent hysterectomy that showed a residue of the tumor and cervical metastasis from the earlier breast carcinoma. The differential diagnosis of UTROSCT and the role of immunohistochemistry in confirming a diagnosis are discussed.

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“…Sir : I would like to thank Dr Zamecnik and coworkers for their interest in our recent publication 1 . We understand their surprise at the absence of myoid differentiation in any of the retiform areas of our six cases of uterine tumours resembling ovarian sex‐cord tumours (UTROSCTs), compared with their positive findings in two of their cases 2,3 .…”

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confidence: 88%