Retina Oculomics in Neurodegenerative Disease

Suh, Alex; Ong, Joshua; Kamran, Sharif Amit; Waisberg, Ethan; Paladugu, Phani; Zaman, Nasif; Sarker, Prithul; Tavakkoli, Alireza; Lee, Andrew G.

doi:10.1007/s10439-023-03365-0

Cited by 11 publications

(3 citation statements)

References 119 publications

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“…In the preclinical stages of the disease, where subjects show positive disease biomarkers and normal cognition, functional and structural ophthalmological changes are already found [ 24 ]. Therefore, oculomics opens the opportunity to monitor and diagnose, before clinical manifestations appear, both systemic diseases (such as diabetes, arterial hypertension, and sarcopenia) and neurodegenerative diseases (AD, Parkinson’s disease, or multiple sclerosis), thus improving quality of life of patients [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives

Sánchez-Puebla,

López-Cuenca,

Salobrar-García

et al. 2024

Biomedicines

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The murine models of Alzheimer’s disease (AD) have advanced our understanding of the pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) have complemented histological methods; however, the lack of standardisation in OCT methodologies for murine models of AD has led to significant variations in the results of different studies. A literature search in PubMed and Scopus has been performed to review the different methods used in these models using OCT and to analyse the methodological characteristics of each study. In addition, some recommendations are offered to overcome the challenges of using OCT in murine models. The results reveal a lack of consensus on OCT device use, retinal area analysed, segmentation techniques, and analysis software. Although some studies use the same OCT device, variations in other parameters make the direct comparison of results difficult. Standardisation of retinal analysis criteria in murine models of AD using OCT is crucial to ensure consistent and comparable results. This implies the application of uniform measurement and segmentation protocols. Despite the absence of standardisation, OCT has proven valuable in advancing our understanding of the pathophysiology of AD.

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Section: Introductionmentioning

confidence: 99%

OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives

Sánchez-Puebla,

López-Cuenca,

Salobrar-García

et al. 2024

Biomedicines

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“…However, it is not possible to differentiate between the two entities. 9 In MS patients with acute optic neuritis (ON), rarefication of superficial retinal vessels occurs in parallel to ON-related ganglion cell and inner plexiform layer (GCIP) atrophy within the initial 3 months. 10 – 13 Recent data suggest that retinal vessel loss is also evident in eyes without an ON history in MS and might be associated with disease activity.…”

Section: Introductionmentioning

confidence: 99%

Retinal small vessel pathology is associated with disease burden in multiple sclerosis

Wicklein,

Kreitner,

Wild

et al. 2024

Mult Scler

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Background: Alterations of the superficial retinal vasculature are commonly observed in multiple sclerosis (MS) and can be visualized through optical coherence tomography angiography (OCTA). Objectives: This study aimed to examine changes in the retinal vasculature during MS and to integrate findings into current concepts of the underlying pathology. Methods: In this cross-sectional study, including 259 relapsing–remitting MS patients and 78 healthy controls, we analyzed OCTAs using deep-learning-based segmentation algorithm tools. Results: We identified a loss of small-sized vessels (diameter < 10 µm) in the superficial vascular complex in all MS eyes, irrespective of their optic neuritis (ON) history. This alteration was associated with MS disease burden and appears independent of retinal ganglion cell loss. In contrast, an observed reduction of medium-sized vessels (diameter 10–20 µm) was specific to eyes with a history of ON and was closely linked to ganglion cell atrophy. Conclusion: These findings suggest distinct atrophy patterns in retinal vessels in patients with MS. Further studies are necessary to investigate retinal vessel alterations and their underlying pathology in MS.

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“…The retina is physically connected to the brain through optic nerves axon, in addition, the brain and retina are morphologically and physiologically very similar (Patton et al, 2005). The close connections between the brain and the retina are used in various experimental models to study neurodegenerative processes (Moons et al, 2022;Suh et al, 2023). In modern literature, information is increasingly found about the presence of a number of visual dysfunctions in patients with AD.…”

Section: Introductionmentioning

confidence: 99%

Histological Examination of Retinal Function and the Effects of Curcuma Longa on Memory Correction in Experimental Olfactory Bulbectomy Rat Models

Gashimova

2024

ABES

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According to the latest literature data, histological studies of the retina in animal models of experimental Alzheimer's disease prove invaluable for identifying the disease in its early stages. The effects of plant antioxidants in disease rehabilitation can be determined by histological analysis of the retina. For this purpose, rats were used as the research object. Experimental animals were trained in the Morris maze to form and study spatial memory. To study the effects of herbal substances on memory correction curcuma was used in experimental animals. Histological analysis of the retina was comparatively analyzed in control, bulbectomized animals and curcuma-treated animals after bulbectomy. The histological materials obtained show that curcuma has a neuroprotective effect on histological changes animal retinas after bulbectomy and dysfunctions accompanied by deterioration of visual memory.

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Retina Oculomics in Neurodegenerative Disease

Cited by 11 publications

References 119 publications

OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives

OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives

Retinal small vessel pathology is associated with disease burden in multiple sclerosis

Histological Examination of Retinal Function and the Effects of Curcuma Longa on Memory Correction in Experimental Olfactory Bulbectomy Rat Models

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