Retinal Astrocytomas: Long-Term Follow-Up

Töteberg‐Harms, Marc; Sturm, Veit; Sel, Saadettin; Sasse, Anna C; Landau, Klara

doi:10.1055/s-0031-1273228

Cited by 12 publications

(6 citation statements)

References 8 publications

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“…Some confusion exists in the literature because of the tendency to use astrocytic tumor (astrocytoma) interchangeably with astrocytic hamartoma, particularly when associated with tuberous sclerosis or, much less commonly, neurofibromatosis type 1. 46 Combined hamartoma of the retina and pigment epithelium found in neurofibromatosis type 2 must be distinguished; 47 epiretinal membranes are more likely to occur in this variant of the disease. 48,49 …”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, there is a reported case of a VPTR associated with neurofibromatosis, but this lesion was not studied histopathologically. 51 Hamartomas have a prominent intrinsic vasculature (clinically, angiographically, and histopathologically), lack calcification initially but may acquire it 46 (some, however, can be congenitally calcified), evince prominent reactive gliosis in the adjacent retina, and are GFAP-positive. 50,52 On rare occasions such hamartomatous tumors have been documented to display rapid and aggressive growth and display cells with atypical nuclei.…”

Section: Discussionmentioning

confidence: 99%

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Reactive Retinal Astrocytic Tumors (So-called Vasoproliferative Tumors): Histopathologic, Immunohistochemical, and Genetic Studies of Four Cases

Perry

Jakobiec

Zakka

et al. 2013

American Journal of Ophthalmology

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Purpose To evaluate the cellular nature of and diagnostic terminology used in connection with acquired retinal “vasoproliferative tumors.” Design Retrospective clinicopathologic study. Methods Clinical records and microscopic slides of 4 enucleated globes were reviewed. Special stains and immunohistochemical probes for CD31, CD34, p53, glial fibrillary acidic protein (GFAP), CD163, and Ki67 (cell replication) were employed; ultrastructural and fluorescence in situ hybridization (FISH) analyses were performed. Results Tumors were located inferotemporally in middle-aged patients. They were uniformly composed of compacted elongated, GFAP-positive spindle cells (due to intermediate filaments identified ultrastructurally) with a Ki67 index of less than 1%. Rosenthal fibers and eosinophilic granular bodies were observed. Hyalinized periodic acid–Schiff-positive vessels were widely separated. CD31 and CD34 revealed a sparse microvasculature. Tumor-associated exudate spread predominantly subretinally. The retinal pigment epithelium had undergone extensive placoid fibrous metaplasia with focal ossification. P53 upregulation, BRAF-KIAA gene rearrangement, and IDH1 R132H mutation typically associated with low-grade astrocytic neoplasms were absent. Conclusions Retinal “vasoproliferative” tumors have been mischaracterized, because they actually display a paucity of microvessels. Proliferating fibrous astrocytes with a very low proliferation index predominate, without immunohistochemical or genetic evidence favoring a neoplasm. Subretinal exudate appeared capable of provoking widespread fibrous metaplasia of the pigment epithelium that was mainly responsible for secondary retinal damage. The term “reactive retinal astrocytic tumor” is proposed as more appropriate for this entity. In carefully selected progressive lesions, consideration should be given to earlier surgical intervention before extensive subretinal exudate accumulates and pigment epithelial proliferation with fibrous metaplasia ensues.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Reactive Retinal Astrocytic Tumors (So-called Vasoproliferative Tumors): Histopathologic, Immunohistochemical, and Genetic Studies of Four Cases

Perry

Jakobiec

Zakka

et al. 2013

American Journal of Ophthalmology

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“…50 % aller TSC-Patienten astrozytäre Hamartome der Netzhaut entwickeln [44]. Astrozytäre Hamartome der Netzhaut können auch bei der Neurofibromatose Typ 1 (Morbus Recklinghausen) und der Neurofibromatose Typ 2 auftreten [45,46].…”

Section: Retinales Astrozytomunclassified

Tumoren und Pseudotumoren der Netzhaut und des Ziliarepithels

Biewald¹,

Schlüter²,

Kiefer³

et al. 2020

Augenheilkunde up2date

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ZusammenfassungDie Varietät retinaler Tumoren reicht von harmlosen Läsionen über benigne, lokal destruierende Tumoren bis hin zu lebensbedrohlichen Erkrankungen. Nicht immer lassen sie sich einfach voneinander unterscheiden. Die Diagnose sollte nach Möglichkeit klinisch gestellt werden wegen der Gefahr einer Tumorzellverschleppung durch invasive Diagnostik. Jedoch rückt die genetische Charakterisierung der Läsion immer mehr in den Vordergrund. Je nach Entität ist eine Therapie in einem spezialisierten Zentrum notwendig.

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“…Astrozytome können solitär auftreten oder multipel und betreffen beim Vorliegen einer Phakomatose möglicherweise auch beide Augen. In den meisten Fällen sind sie in ihrer Größe konstant mit nur geringer struktureller Veränderung der Tumoren über Jahre und bedürfen somit keiner therapeutischen Intervention [18]. Klinisch sind Astrozytome insbesondere dann nicht von Retinoblastomen zu trennen (l " Abb.…”

Section: Morbus Coatsunclassified

Intraokulare Raumforderungen im Kindesalter ohne Retinoblastom

Schlueter

Metz

Bornfeld

et al. 2015

Klin Monatsbl Augenheilkd

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The diagnosis of an intraocular mass in children can be challenging as invasive procedures are not allowed, in particular if a retinoblastoma may be present. In eyes with a unilateral tumour mass and loss of function enucleation with subsequent histopathological processing might be the only option to establish a diagnosis and to exclude a malignant tumour. The present paper deals with intraocular tumours other than retinoblastoma in children, with a special focus on the correlation of modern imaging techniques and histopathological findings.

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Retinal Astrocytomas: Long-Term Follow-Up

Cited by 12 publications

References 8 publications

Reactive Retinal Astrocytic Tumors (So-called Vasoproliferative Tumors): Histopathologic, Immunohistochemical, and Genetic Studies of Four Cases

Reactive Retinal Astrocytic Tumors (So-called Vasoproliferative Tumors): Histopathologic, Immunohistochemical, and Genetic Studies of Four Cases

Tumoren und Pseudotumoren der Netzhaut und des Ziliarepithels

Intraokulare Raumforderungen im Kindesalter ohne Retinoblastom

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