Retinal capillary hemangioblastoma and hemiretinal vein occlusion in a patient with primary congenital glaucoma: A case report

AlBloushi, Abdulrahman F; Taşkintuna, İbrahim; Nowilaty, Sawsan R.

doi:10.1016/j.sjopt.2018.11.008

Cited by 1 publication

(1 citation statement)

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“…However, the mechanisms of CRVO caused by VHL disease could be diverse. In the report of AlBloushi AF et al [ 19 ], a 22-year-old woman with VHL disease developed hemiretinal vein occlusion due to the mechanical compression of the juxtapapillary RCH. Our patient refused intravitreal anti-VEGF.…”

Section: Discussionmentioning

confidence: 99%

Von Hipple-Lindau disease complicated with central retinal vein occlusion: a case report

Chen

Wang²,

Tang

et al. 2022

BMC Ophthalmol

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Background Central Retinal Vein Occlusion (CRVO) is a rare complication of von Hipple-Lindau (VHL) disease. This report presents the first case of VHL disease complicated with CRVO caused by VHL c.208G > A mutation. Case presentation A 20 s man whose left eye visual acuity gradually declined for half a year. The visual acuity of the left eye is counting fingers. Fundus examination revealed that retinal hemangioblastoma was also found in addition to typical CRVO signs such as tortuous expansion of retinal veins and flame-shaped hemorrhage of the retina. Liver tumor, cerebral infarction and erythrocytosis were found during systemic examination, and the diagnosis of polycythemia was confirmed by bone marrow smear. Furthermore, both family history and genetic analysis indicated that the patient had VHL disease caused by VHL c.208G > A. In this patient, a large number of bone marrow erythrocytes proliferated due to VHL disease, which led to the increase of blood viscosity and erythrocyte vascular adhesion, resulting in the obstruction of central retinal vein blood flow, and finally CRVO. For CRVO and its pathogenic factor polycythemia, patient received laser retinal photocoagulation and phlebotomies. After a 1-year follow-up, the vision in the left eye improved to 0.2 logMAR. Conclusions This is a rare case of polycythemia complicated by CRVO in patient with VHL disease. It reminds us that the systemic disease factors should be fully considered in the diagnosis of young patients with CRVO, and that treatment requires a coordinated effort of physicians.

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Section: Discussionmentioning

confidence: 99%