Retinal choroidal and retinal nerve fiber layer thickness in former preterm and full-term infants aged 4 to 8 years

Acar, Damla Ergintürk; Acar, Uğur; Tunay, Zühal Özen; Arman, Ayşegül; Göksülük, Dinçer

doi:10.1007/s10792-020-01666-0

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…No published data exist on peripapillary choroidal thickness for adults born preterm, while data on choroidal thickness in preterm children, mostly assessing the macular region, are limited and controversial, with prematurity previously linked to a thinning of the subfoveal and temporal choroidea in children. 15 , 26 However, Acar et al did not find an association between subfoveal choroidal thickness and prematurity, 13 whereas the Copenhagen Child Cohort 2000 Eye study reported an association between being small for gestational age and subfoveal choroidal thinning. 14 Several other studies found an association between prematurity and/or birth weight and CT thinning in the macula.…”

Section: Discussionmentioning

confidence: 99%

“…The few studies evaluating the effects of prematurity and low birth weight on choroidal thickness (CT) at the posterior pole in childhood have yielded controversial findings, with some studies reporting no correlation between gestational age and subfoveal CT, 13 whereas most studies found a an association between prematurity and/or birth weight and CT thinning in the macula. 11 , 14 – 16 However, there is a lack of published data assessing the association of birth parameters with foveal and peripapillary choroidal thicknesses in adulthood.…”

Section: Introductionmentioning

confidence: 99%

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Foveal and Peripapillary Choroidal Thickness in Adults Born Extremely, Very, and Moderately Preterm With and Without ROP–Results From the Gutenberg Prematurity Eye Study

Fieß

Schulze

Grabitz

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose The present study investigated the long-lasting effect of prematurity, prenatal growth restriction, and associated factors on foveal and peripapillary choroidal thickness in adulthood. Methods The Gutenberg Prematurity Eye Study (GPES) is a retrospective cohort study with a prospective ophthalmologic examination in Germany. Foveal and peripapillary choroidal thicknesses were measured at different sectors using spectral-domain optical coherence tomography. Multivariable linear regression analyses were performed to determine associations among gestational age, birth weight percentile, retinopathy of prematurity (ROP) occurrence and treatment, and other perinatal factors, such as maternal smoking and others with foveal and global peripapillary choroidal thickness. Results A total of 735 eyes of 408 study participants were included (age = 28.4 ± 8.6 years, 229 women). Multivariable regression analyses revealed that foveal choroidal thinning was associated with maternal smoking during pregnancy (B = −38.1, 95% confidence interval [CI] = −65.5 to −10.7, P = 0.006), whereas other perinatal factors revealed no association. Global peripapillary choroidal thinning showed a trend to a lower birth weight percentile (B = 0.22, 95% CI = −0.01 to 0.45, P = 0.057). No correlation was observed between foveal and peripapillary choroidal thicknesses with visual acuity. Conclusions This study indicates that maternal cigarette smoking during pregnancy has adverse long-lasting effects on choroidal development in the fovea and low birth weight percentile as a surrogate marker for adverse perinatal growth might be linked with peripapillary choroidal thinning whereas prematurity showed no long-term effects. Translational Relevance Altered choroidal layer development caused by perinatal influence factors might be a risk factor for reduced visual function and predispose affected individuals to eye diseases in later life.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Foveal and Peripapillary Choroidal Thickness in Adults Born Extremely, Very, and Moderately Preterm With and Without ROP–Results From the Gutenberg Prematurity Eye Study

Fieß

Schulze

Grabitz

et al. 2022

Trans. Vis. Sci. Tech.

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“…Other studies have also not found a significant difference in choroidal thickness of former full-term versus preterm infants based on GA alone once they reach 4 to 10 years old. 25 , 26 We will follow the choroidal growth, refractive error, and visual acuity in our cohort at early school age as part of BabySTEPS2.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Choroidal Development in Preterm Infants

Michalak,

Mangalesh,

Chen

et al. 2024

Ophthalmology Science

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“…Both severe ROP stage and previous ablative treatment with laser or cryotherapy have been linked as causes of axonal damage. [ 4 7 16 17 ] RNFL thinning has also been reported in patients with low birth weight. It is suggested that babies with higher birth weights have a greater reserve of retinal ganglion cells,[ 4 7 9 ] and that hypoxic and inflammatory conditions in the premature patient contribute to neuronal damage.…”

mentioning

confidence: 95%

A comparison of posterior segment optical coherence tomography findings in full-term and preterm children without retinopathy of prematurity

Martínez-Córdoba

Quijano-Nieto

Echeverría-González

et al. 2021

Indian Journal of Ophthalmology

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Purpose: Structural differences have been described in the retina of prematurely born children, including increased macular thickness caused by failed migration of the inner retina during development and retinal nerve fiber layer (RNFL) thinning related to low birth weight. The present study aimed to evaluate the differences in macular and RNFL optical coherence tomography (OCT) findings between full-term and preterm children without retinopathy of prematurity (ROP). Methods: Thirty-four premature (study group) and 43 full-term patients (control group)—aged 3 to 8 years—were studied. All children underwent a complete ophthalmological exam and OCT of the macula and optic nerve in both eyes to determine macular and RNFL thickness and morphology. Correlation analysis between central macular thickness, age, and visual acuity was also performed. Results: Central macular thickness was greater in the study group than in the control group; a difference of 14.2 μm was observed for the right eye ( P = 0.002) and 12.16 μm for the left eye ( P = 0.019). The thickness of the parafoveal and the perifoveal zones was consistently greater in the study group. 44.3% of eyes in the study group had mild forms of foveal hypoplasia (grades 1a and 1b) in qualitative description. No correlation between central macular thickness and visual acuity was found. There was no difference in RNFL thickness between both groups. Conclusion: Statistically significant structural differences were found in the macula of premature children, with a greater foveal thickness possibly reflecting retention of the inner retina during development, with no repercussion over visual acuity. RNFL thickness was similar in both groups.

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Retinal choroidal and retinal nerve fiber layer thickness in former preterm and full-term infants aged 4 to 8 years

Cited by 6 publications

References 30 publications

Foveal and Peripapillary Choroidal Thickness in Adults Born Extremely, Very, and Moderately Preterm With and Without ROP–Results From the Gutenberg Prematurity Eye Study

Foveal and Peripapillary Choroidal Thickness in Adults Born Extremely, Very, and Moderately Preterm With and Without ROP–Results From the Gutenberg Prematurity Eye Study

Longitudinal Choroidal Development in Preterm Infants

A comparison of posterior segment optical coherence tomography findings in full-term and preterm children without retinopathy of prematurity

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