2022
DOI: 10.3389/fnmol.2022.1076430
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Retinal degeneration protein 3 controls membrane guanylate cyclase activities in brain tissue

Abstract: The retinal degeneration protein RD3 is involved in regulatory processes of photoreceptor cells. Among its main functions is the inhibition of photoreceptor specific membrane guanylate cyclases during trafficking from the inner segment to their final destination in the outer segment. However, any physiological role of RD3 in non-retinal tissue is unsolved at present and specific protein targets outside of retinal tissue have not been identified so far. The family of membrane bound guanylate cyclases share a hi… Show more

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Cited by 3 publications
(6 citation statements)
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“…We interpret this result as indicating that the effect of RD3 on cell-cycle control is specific, because locations of the point mutations are at critical positions of the interface region interacting with guanylate cyclases [10], and any disturbance might weaken or diminish the impact of RD3 on cell cycle control. The interaction profile of RD3 is not restricted to photoreceptor guanylate cyclases, because we showed recently that the activity of natriuretic peptide receptor guanylate cyclases is controlled by RD3 in a fashion similar to photoreceptor cyclases [13]. These finding points to a more general role of RD3 in a signal transduction pathway involving a membrane bound guanylate cyclase.…”
Section: Discussionmentioning
confidence: 78%
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“…We interpret this result as indicating that the effect of RD3 on cell-cycle control is specific, because locations of the point mutations are at critical positions of the interface region interacting with guanylate cyclases [10], and any disturbance might weaken or diminish the impact of RD3 on cell cycle control. The interaction profile of RD3 is not restricted to photoreceptor guanylate cyclases, because we showed recently that the activity of natriuretic peptide receptor guanylate cyclases is controlled by RD3 in a fashion similar to photoreceptor cyclases [13]. These finding points to a more general role of RD3 in a signal transduction pathway involving a membrane bound guanylate cyclase.…”
Section: Discussionmentioning
confidence: 78%
“…The critical function of RD3 in health and disease apparently extend to non-retinal tissue, since recent investigations in human and mice tissues showed the expression of RD3 in different brain regions and in epithelial cells of various organs [12,13,14,15]. Loss of RD3 expression correlates with the progression of the pathogenesis in neuroblastoma and a poor survival prognosis [12,14].…”
Section: Discussionmentioning
confidence: 99%
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