Retinal fluorescein contrast arrival time of young patients with the hepatosplenic form of the Schistosomiasis mansoni

Souza, Ana Catarina Delgado de; Brandt, Carlos Teixeira; Ventura, Liana O.; Oréfice, Fernando

doi:10.1590/s0074-02762002000900030

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…The fact that the object of study was the peripapillary region may have influenced the lack of ocular findings, as already described in other studies [4][5][6][7][8][9][10][11][12][13][14][15][16][17] . It was not searched throughout the globe since the intention was to evaluate a particular segment of the eye.…”

Section: Discussionmentioning

confidence: 99%

“…Ocular lesions have been reported with an inflammatory response induced by S. mansoni eggs similar to those observed in the livers of infected hosts. Retinal manifestations, such as hemorrhages, granulomas, tortuosity and enlargement of the vessels were observed in association with the hepatosplenic form [4][5][6][7][8][9][10][11][12][13][14][15][16][17] . Damage to the retinal nerve fiber layer and the retard of retinal contrast arrival time in the angiofluoresceinographic exam were also reported due to ocular hemodynamic alterations 6,8,11 .…”

Section: Introductionmentioning

confidence: 99%

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Histological and histomorphometric evaluation of the retina of mice infected with Schistosoma mansoni in its hepatosplenic form

Remígio¹,

Brandt²,

Filho³

et al. 2009

Acta Cir. Bras.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histological and histomorphometric evaluation of the retina of mice infected with Schistosoma mansoni in its hepatosplenic form

Remígio¹,

Brandt²,

Filho³

et al. 2009

Acta Cir. Bras.

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Schistosomiasis

Oréfice¹,

Fernandes²,

Delgado³

2016

Intraocular Inflammation

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Ocular pathological changes in hamsters experimentally infected withSchistosoma mansoni

Ismail¹,

Ashour²,

Rayia³

et al. 2016

J. Helminthol.

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Ocular lesions have been reported in patients with schistosomiasis; however, the problem with studying schistosomal infection of the human eye is that biopsies are almost impossible to take, and histopathological examination of suspicious lesions can only be undertaken post-mortem or after enucleation. This work aimed to study the possible effects and pathogenesis of schistosomiasis on the eye. This study involved 55 hamsters; five hamsters remained non-infected and the remaining 50 hamsters were infected with Schistosoma mansoni cercariae. Infected hamsters were sacrificed on weeks 8, 12, 16 and 20 post-infection (pi). Eye sections were prepared and stained for histopathological and immunohistochemical studies. Histopathological changes detected in hamsters infected after 16 and 20 weeks included looseness and oedema of the innermost retinal layers together with hyperplastic polypoid growth. Neither eggs nor granulomata were detected in eye sections throughout the experimental period. Deposition of S. mansoni antigen was revealed in 35% of infected hamsters. Later, on weeks 16 and 20 pi, moderate subepithelial conjuctival deposits and marked subchoroidal and scleral deposition were detected. In conclusion, the deposition of schistosomal antigen and immune complexes may play a pivotal role in the ocular changes that occur in schistosomiasis, even in the absence of detectable Schistosoma eggs. Schistosomiasis should be suspected in cases with unexplained ophthalmological findings, especially in endemic areas.

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Retinal fluorescein contrast arrival time of young patients with the hepatosplenic form of the Schistosomiasis mansoni

Cited by 3 publications

References 6 publications

Histological and histomorphometric evaluation of the retina of mice infected with Schistosoma mansoni in its hepatosplenic form

Histological and histomorphometric evaluation of the retina of mice infected with Schistosoma mansoni in its hepatosplenic form

Schistosomiasis

Ocular pathological changes in hamsters experimentally infected withSchistosoma mansoni

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