Retinal Function in Patients with Adalimumab Treatment: Long-term Follow-up with Microperimetry

Abstract

Purpose: To examine the effects of a biological treatment (adalimumab) on visual function in patients with ankylosing spondylitis and in uveitic patients without macular edema during one-year treatment with adalimumab. Methods: Sixteen eyes of eight consecutive Caucasian patients treated with adalimumab were followed up using microperimetry (MAIA; CenterVue, Padova, Italy). Five patients had ankylosing spondylitis without uveitis, three patients had panuveitis without macular edema. Macular sensitivity and macular integrity were recorded. Results: During six-month follow-up, the average threshold did not change significantly (p = .649). Macular integrity was stable (p = .225). The macular sensitivity point analysis showed no significant effects (examination F(3,56) = 0.494 and p = .688; point*examination F(108,2016) = 0.688 and p = .994) during the follow-up. Conclusions: During one-year follow-up, adalimumab did not affect macular function, unlike the well-established maculopathy induced by hydroxychloroquine. Microperimetry may be considered when following-up macular function in patients undertaking adalimumab.

Clinical Utility of Morphofunctional Correlation of Microperimetry and Optical Coherence Tomography

“…29 In an eye with 20/20 BCVA, nonproliferative diabetic retinopathy, and no clinical findings of retinal hemorrhage or macular edema to explain new symptoms of central visual impairment (Case 4, Figure 4), we were able to correlate focal In Case 5 (Figure 5), we demonstrated the potential to use sequential registered microperimetry RS maps and OCT B-scans to assess response to immunosuppressive therapy in an eye with visual field loss due to recurrent PIC. 30 We observed a clear association between reduced RS and the severity of EZ disruption imaged with OCT. As shown by other investigators, the area of transient EZ disruption also appeared hyperautofluorescent on FAF. 31 Restoration of the EZ occurring with oral corticosteroids was accompanied by recovery of RS.…”