Retinal function with lens-induced myopia compared with form-deprivation myopia in chicks

Fujikado, Takashi; Kawasaki, Yoichi; Suzuki, Atsushi; Ohmi, Genjiro; Tano, Yasuo

doi:10.1007/bf01739642

Cited by 48 publications

(42 citation statements)

References 17 publications

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“…We reported earlier that the eyes of chicks elongated to compensate for the effect of minus lenses (up to -16 dpt) in 6 days after the application of the lenses [6]. In this study, we investigated the effect of L-NAME, an inhibitor of nitric oxide synthetase (NOS), on the development of LIM under the same conditions.…”

Section: Discussionmentioning

confidence: 99%

“…This lens assembly positioned the lenses 5 mm in front of the corneal surface of the chick's eye. The absolute power of the lens was -18.0 dpt [6]. To prevent blurring of vision by the condensation of moisture on the lenses, a coating was sprayed on the inner and outer surfaces of the assembly before it was applied to the eye.…”

Section: Goggle-lens Assembly To Induce Myopiamentioning

confidence: 99%

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Effect of a Nitric Oxide Synthase Inhibitor on Lens-Induced Myopia

Fujikado¹,

Tsujikawa²,

Tamura³

et al. 2001

Ophthalmic Res

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Purpose: It has still not been determined whether the retinal mechanism causing form-deprivation myopia (FDM) is different from that causing lens-induced myopia (LIM). We previously reported that FDM was blocked by an intravitreal injection of the nitric oxide (NO) synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME). In this study, we investigated the effect of L-NAME on LIM in chicks. Method: The left eyes of 6-day-old chicks were injected with 30 µl of nontoxic concentrations of L-NAME (≤360 mM) or saline. The right eyes were injected with 30 µl of saline. A –16 dpt lens was placed in front of the left eye for 6 days. Another group of 6 chicks were injected with 180 mML-NAME (left eye) and with saline (right eye) before placing –16 dpt lenses in front of both eyes. After removing the lens, the refraction and the axial length were measured. The effect of L-NAME (180 mM) on the retina of a separate group of chicks was examined by electroretinography 60 min after an intravitreal injection in non-LIM-treated eyes. Results: The eyes of chicks that were injected with 180 or 360 mML-NAME were less myopic and had significantly shorter axial lengths than control eyes. A significant decrease of the On response and an increase of the Off response were observed. Conclusion: The injection of L-NAME into developing chick eyes that were then covered with a –16 dpt lens resulted in a modifications of retinal function and an inhibition of the development of myopia. These results, combined with the earlier findings, suggest that NO modulates a common retinal pathway that leads to both LIM and FDM.

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Section: Discussionmentioning

confidence: 99%

Section: Goggle-lens Assembly To Induce Myopiamentioning

confidence: 99%

Effect of a Nitric Oxide Synthase Inhibitor on Lens-Induced Myopia

Fujikado¹,

Tsujikawa²,

Tamura³

et al. 2001

Ophthalmic Res

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“…osilatuar potansiyel (OP) amplitüdlerinin uzun aksiyel uzunluk'lu gözlerde zayıflamış olduğunu bulmuş ve fonksiyonel değişikliklerin deprive-form miyopik retinanın iç tabakasından ortaya çıktığını ileri sürmüşlerdir. 15 Son elektrofizyolojik çalışma, yüksek miyopik ço-cuklarda anormal retinal fonksiyon bulguları gö-steren ERG bulguları olmuştur. Araştırmacılar, retinal disfonksiyonun insan emetrop sürecinin tahribi sonucu oluştuğunu ve refraksiyon kusuru gelişimi ile sonuçlanabileceğini öne sürmüşlerdir.…”

Section: Discussionunclassified

Multifocal Electroretinography in Myopia

Tokgöz¹,

Özkağnıcı²,

Gündüz³

et al. 2016

Turkiye Klinikleri J Ophthalmol

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öz hastalıkları polikliniğine başvuran hastaların %30-35'i refraksiyon kusuru tanısı almaktadır. Bu hasta grubunun %39'unda ise miyopi saptanmaktadır. Miyoplarda Multifokal Elektroretinografi Ö ÖZ ZE ET T A Am ma aç ç: : Miyop bireylerde maküla ve periferik retina fonksiyonlarının multifokal elektroretinografi (Mf-ERG) ile incelenmesidir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Yüz on sekizi kadın, ve 106'sı erkek, olmak üzere toplam 224 hasta Mf-ERG ile incelendi. Kırma kusuru derecesine göre hastalar dört gruba ayrıldı. Birinci grup 0,00-0,75 D (kontrol grubu), ikinci grup -1,00-3,00 D, üçüncü grup -3,25-6,00 D, dördüncü grup -6,25-12,00 D miyoplardan oluşturuldu. Mf-ERG ile 1. kernel yanıt-ları incelendi. B Bu ul lg gu ul la ar r: : Mf-ERG ilk pzitif (P1) ve ilk negatif (N1) amplitüdleri santral bölge dışında perifere doğru azalırken, latanslar santral bölge de dahil hemen hemen tüm halkalarda uzamış bulundu. N1 dalgası amplitüd ve latans değerleri aksiyel uzunluk/sferik ekivalan (AU/SE) ile zayıf orta şiddette korelasyon gösterirken, P1 dalgası amplitüd ve latans değerleri AU/SE ile hiçbir halkada korelasyon göstermedi. S So on nu uç ç: : Yüksek miyoplardaki Mf-ERG yanıtlarında anlamlı farklılığın AU ve SE'nin etkisinden ziyade oldukça kompleks bir yapıya sahip olan retinadan kaynaklandığı düşü-nülmektedir. Mf-ERG yanıtlarında hem latans hemde amplitüdlerin bozulması ise miyopide iç ve dış retinal fonksiyonların bozulduğunu göstermektedir A An na ah ht ta ar r K Ke el li im me el le er r: : Elektroretinografi; miyopi; retina A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To evaluate the macular and peripheral retinal functions in myopic subjects using multifocal electroretinography (Mf-ERG). M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : 118 females and 106 males, a total of 224 subjects were evaluated using Mf-ERG. The subjects were divided into four groups according to the refractive error: first group consisted of myopia 0.00-0.75 D (control group), second group 1.00-3.00 D, third group 3.25-6.00 D, fourth group 6.25-12.00 D. 1. order Kernel responses were evaluated using Mf-ERG. R Re es su ul lt ts s: : While the Mf-ERG first positive (P1) and first negative (N1) amplitudes decreased towards the periphery except the central area, the latencies increased in all rings including the central area. The amplitude and latency of the N1 wave showed a weak medium correlation with the axial length/spheric equivalent (AL/SE), but no correlation was noted between the P1 wave amplitude and latency and AL/SE in any of the rings. C Co on nc cl lu us si io on n: : The reason for the significant difference of Mf-ERG responses in high myopes is thought to result from the complex structure of the retina rather than the effects of AL and SE. The impairment of latencies and amplitudes in Mf-ERG responses implies that the inner and outer retinal layer functions are deteriorated in myopia.K Ke ey y W Wo or rd ds s: : Electroretinography; myopia; retina T Tu ur rk ki iy ye e K Kl li in ni ik ...

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“…It has been reported that myopia induced by negative lenses produced axial-length elongation and refractiveerror changes that were dependent on the lens power [11,35] . Irving et al [33,40] reported that positive and negative lenses ranging in power from -20 to +30 D induced myopia and hyperopia in hatching chicks, but these lenses did not change the lens thickness between control and treated eyes.…”

Section: Discussionmentioning

confidence: 99%

“…Negative lens-induced chick myopia models with axial-length elongation have been widely used to investigate the mechanism of myopia progression [35] and also to evaluate the effects of drugs such as atropine [36] and pirenzepine [37] , which prevent myopic progression and axial-length growth in children [38,39] . Therefore, we used the negative lens (-8 D)-induced myopia model in chicks to evaluate the efficacy of BC extract in preventing myopia-related changes.…”

Section: Discussionmentioning

confidence: 99%

Effect of Black-Currant Extract on Negative Lens-Induced Ocular Growth in Chicks

Iida¹,

Nakamura²,

Matsumoto³

et al. 2010

Ophthalmic Res

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Aim: To evaluate the effects of orally administered black-currant (BC) extract on the enlargement of globe component dimensions induced in chicks by wearing negative lenses. Methods: Negative lenses (–8 D) were worn on the right eyes by 8-day-old chicks, and their fellow eyes acted as controls. BC extract and distilled water (vehicle control) were orally administered once a day for 3 days. To confirm the effect of BC anthocyanins (BCAs), they were intravenously administered once a day for 3 days. Dimensions of globe components of right eyes and fellow eyes were measured with an A-scan ultrasound instrument on the third day (day 4) after placement of the negative lenses. Results: Orally administered BC extract significantly inhibited enlargement of vitreous-chamber depth, axial and ocular lengths in a dose-dependent manner when compared to controls. Intravenously administered BCAs also inhibited elongation of vitreous-chamber depth and axial length when compared to controls. Conclusions: This is the first evidence that BC extract and BCAs could inhibit enlargement of globe component dimensions in a negative lens-induced chick myopia model.

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Retinal function with lens-induced myopia compared with form-deprivation myopia in chicks

Abstract: Retinal function differs in LIM and FDM, as indicated by differences in the oscillatory potentials. This difference may stem from the fact that in FDM the retinal image is continuously defocused, whereas images are ultimately focused on the retina in LIM.

Cited by 48 publications

References 17 publications

Effect of a Nitric Oxide Synthase Inhibitor on Lens-Induced Myopia

Effect of a Nitric Oxide Synthase Inhibitor on Lens-Induced Myopia

Multifocal Electroretinography in Myopia

Effect of Black-Currant Extract on Negative Lens-Induced Ocular Growth in Chicks

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