Retinal Ganglion Cell Death

Budak, Yasemin; Joshi, Mohan P

doi:10.5772/19003

Cited by 2 publications

(1 citation statement)

References 134 publications

(108 reference statements)

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“…The main factors contributing to NTG-related GON can be distinguished into two main categories, namely vascular and mechanical. These factors can lead to retinal ganglion cell (RGC) loss and axonal damage via several pathways (3). In addition, various genes have been found to be involved in NTG, thus suggesting a genetic predisposition for NTG development (4).…”

Section: Introductionmentioning

confidence: 99%

Normal‑tension glaucoma: Pathogenesis and genetics (Review)

et al. 2018

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Normal-tension glaucoma (NTG) is a multifactorial optic neuropathy which, similar to open-angle glaucomas, is characterized by progressive retinal ganglion cell death and glaucomatous visual field loss. The major distinction of NTG from open-angle glaucomas is that the intraocular pressure (IOP) does not exceed the normal range. Missing the major risk factor and target of therapy, the elevated IOP, NTG poses a clinical challenge. Several insightful reviews have been published on the pathophysiology of NTG describing the possible underlying mechanisms. The current literature available also suggests that a significant percentage of patients with NTG (as high as 21%) have a family history of glaucoma, indicating a genetic predisposition to the disease. These facts strengthen the indication that NTG remains an enigmatic process. The aim of this review was to summarize the vascular, mechanical and genetic components considered to be responsible for NTG development and to discuss the mechanisms through which they are involved in the pathogenesis of NTG.

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Section: Introductionmentioning

confidence: 99%