Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis

Abstract

Background Structural retinal imaging biomarkers are important

Multifocal visual evoked potentials and contrast sensitivity correlate with ganglion cell-inner plexiform layer thickness in multiple sclerosis

“…Spectral-domain optical coherence tomography (OCT) has emerged as a sensitive technique to assess thickness changes from discrete retinal layers in MS eyes (Petzold et al, 2017). Recent studies suggest that compared to peripapillary retinal nerve fiber layer (RNFL) thickness (RNFLT), macular ganglion cell-inner plexiform layer (GCIPL) thickness (GCIPLT) can be more selective in quantifying and tracking neurodegeneration in MS as it is less confounded by gliosis and edema found in the RNFL (Green et al, 2010, Saidha et al, 2011, Ratchford et al, 2013, Gonzalez-Lopez et al, 2014, Narayanan et al, 2014, Kupersmith et al, 2016, Britze et al, 2017, Pietroboni et al, 2017).…”

Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

“…Interpretation: Intereye differences of 5μm for retinal nerve fiber layer and 4μm for macular ganglion cell + inner plexiform layer are robust thresholds for identifying unilateral optic nerve lesions. Demyelination and transection lead to retrograde degeneration of optic nerve axons over time, which can be detected by measuring the pRNFL and GCIPL by OCT. 9,[15][16][17] OCT is useful in monitoring disease progression and in detecting both clinical and subclinical optic nerve degeneration. Our findings lend further validation for utilizing the visual system in a multiple sclerosis clinical trial setting.…”

Retinal nerve fibre layer thinning is associated with worse visual outcome after optic neuritis in children with a relapsing demyelinating syndrome

“…Optical coherence tomography (OCT) and electrodiagnostic tests can be useful paraclinical parameters in patients with optic neuritis . OCT may detect structural retinal changes, such as retinal nerve fibre layer (RNFL) and ganglion cell layer thinning, and the development of microcystic macular oedema and retinal damage . OCT may help to differentiate between multiple sclerosis and NMOSD, with more severe retinal damage and hence greater RNFL thinning detected after optic neuritis in patients with AQP4‐Ab NMOSD .…”