Retinal lead toxicity

Gilhotra, J.S.; Lany, H von; Dm, Sharp

doi:10.4103/0301-4738.30716

Cited by 12 publications

(10 citation statements)

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“…[6] Asymmetric presentation had also been previously described for systemic lead toxicity. [7] We believe that this is the first case report of implant-related cobalt toxicity to the outer retina.…”

Section: Discussionmentioning

confidence: 93%

Hip-implant related chorio-retinal cobalt toxicity

Ebneter

Gilhotra³

2013

Indian J Ophthalmol

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A 39-year-old female with elevated serum cobalt levels from her bilateral hip prostheses presented with a 3-week history of blurred vision in her left eye. Optical coherence tomography revealed patchy degeneration of the photoreceptor-retinal pigment epithelium (RPE) complex. The lesions were hypofluorescent on indocyanine green angiography. We postulate that this is a case of implant-related chorio-retinal cobalt toxicity.

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Section: Discussionmentioning

confidence: 93%

Hip-implant related chorio-retinal cobalt toxicity

Ebneter

Gilhotra³

2013

Indian J Ophthalmol

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“…It is a heavy metal that can pollute air, water and food causing a numerous changes in the human body that may be reversible or not [20]. Lead toxicity may cause loss of vision by affecting eye retina [17]. It may cause circulatory problems, and it may cause excretory problems by affecting the kidney [29].…”

Section: Discussionmentioning

confidence: 99%

“…18 (13 and 14) Apoptosis in group III hepatocytes (15)(16)(17). Healthy hepatocytes in group III (18).…”

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confidence: 97%

Di-Mercapto Succinic Acid (DMSA) and vitamin C chelating potency in lead intoxication, regarding oxidative stress and apoptotic related proteins in rabbits

Raafat¹,

Elbarbary

Touson

et al. 2011

Journal of Genetic Engineering and Biotechnology

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Free radicals interact with other molecules within cells. This can cause oxidative damage to proteins, membranes and genes. Oxidative damage has been implicated in the cause of many diseases such as cancer and Alzheimer's and has an impact on the body's aging process. External factors such as pollution, sunlight and smoking also trigger the production of free radicals and the process of programmed cell death (PCD) that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. The study was conducted to 42 male Orycytolagus Cuniculus rabbits. These animals were subdivided into seven groups approaching the comparison between treatment with vitamin C and Di-Mercapto Succinic Acid (DMSA) including positive and negative control groups. Lead ions concentration in blood, liver, kidney and brain were measured before and after treatments application. Apoptotic related proteins P53 and Bcl2 were estimated beside histological studies of tissues. Results revealed that it is more saving to use vitamin C as a lead chelator than DMSA. It is also can be stated that severe lead toxicity can be carcinogenic by increasing the oxidative stress * Corresponding author. Permanent address:

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“…Lead poisoning can also cause retinal toxicity as shown in a 35-year-old woman who suffered from loss of vision in the right eye (Gilhotra et al, 2007). Another heavy metal, iron, may play a role in retinal and macular degeneration, glaucoma, and cataract (He et al, 2007).…”

Section: Systemic Agents and Ocular Toxicitymentioning

confidence: 98%