Retinal Microvasculature Alteration in Active Thyroid-Associated Ophthalmopathy

Ye, Lei; Zhou, Shuangshuang; Yang, Wenlong; Bao, Jing; Jiang, Nan; Min, You‐Lan; Yuan, Qing; Tan, Gang; Shen, Mei; Shao, Yi

doi:10.4158/ep-2017-0229

Cited by 62 publications

(56 citation statements)

References 22 publications

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“…In a study investigating retinal blood flow by Heidelberg retina flowmeter in patients with TAO, increased retinal blood flow was found in active TAO patients compared to healthy controls. Consistently, Ye et al 20 also found that active TAO patients presented with an increased retinal microvascular density. The discrepancy might mainly ascribe to the difference in study design: the participants these studies were primarily TAO patients uncomplicated with DON.…”

Section: Discussionsupporting

confidence: 58%

“…A recent OCT-A study investigating the retinal vessel changes in active TAO eyes initiated the exploration to the contribution of intraocular blood flow in the development of TAO. 20 In this study, however, we focused primarily on the patients with severe TAO (i.e., those complicated with DON), and also aimed to elucidate the relation of microvascular perfusion and visual function impairment.…”

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confidence: 99%

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Peripapillary and Macular Vessel Density in Dysthyroid Optic Neuropathy: An Optical Coherence Tomography Angiography Study

Zhang

Xiao

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To evaluate peripapillary and macular vessel density in eyes with dysthyroid optic neuropathy (DON) and its correlation with visual function. METHODS. Patients diagnosed as thyroid-associated ophthalmopathy (TAO) with or without DON and healthy participants were recruited. All subjects underwent a complete ophthalmic examination and optical coherence tomography angiography centered on the fovea and the optic nerve head. Microvascular measurements were summarized as vessel density in the whole image and in each subfield. Visual function, including best-corrected visual acuity (BCVA), visual field (VF), and visual evoked potential (VEP), were assessed for all TAO patients. Areas under the receiver operating characteristic curves (AUROCs) were applied to evaluate the diagnostic accuracy of vessel density for DON. RESULTS. A total of 23 healthy eyes, 41 TAO eyes without DON, and 30 with DON were studied. The radial peripapillary capillary whole image vessel density (rpc-wiVD) and optic nerve head whole image vessel density (onh-wiVD) were significantly decreased in DON eyes compared with healthy and non-DON eyes (all P < 0.05). The decrease was more profound in the temporal peripapillary subfields than in others. The impairment of visual function (i.e. BCVA, VF, and VEP) was positively associated with the reduction of onh-wiVD and rpc-wiVD but not related to the rarefaction of macular microvasculature. Moreover, the onh-wiVD showed desirable diagnostic capacity to distinguish the DON eyes from NDON eyes (AUROC, 0.75). CONCLUSIONS. A decrease in vessel density in the peripapillary area is evident in eyes with DON. The attenuation in peripapillary perfusion significantly correlates to the extent of visual impairment.

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Section: Discussionsupporting

confidence: 58%

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confidence: 99%

Peripapillary and Macular Vessel Density in Dysthyroid Optic Neuropathy: An Optical Coherence Tomography Angiography Study

Zhang

Xiao

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…We speculate that the continually decreasing blood supply might be responsible for the transition from non-DON to DON. However, Ye et al [37] reported that the macular microvascular densities were significantly increased in active TAO patients. This discrepancy might be ascribed to the difference in the study design in which Ye et al's subjects were primarily active TAO patients uncomplicated with DON.…”

Section: Discussionmentioning

confidence: 96%

Reduced macular inner retinal thickness and microvascular density in the early stage of patients with dysthyroid optic neuropathy

et al. 2020

Eye and Vis

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Background: The goal was to investigate changes of the inner intra-retinal layer thicknesses and retinal capillary density (RCD) around the macula in thyroid-associated ophthalmopathy (TAO) patients with or without dysthyroid optic neuropathy (DON). Methods: Forty-four TAO patients including 23 non-DON and 21 DON patients, and 38 healthy participants were enrolled. Spectral domain optical coherence tomography equipped with Angiovue was used to obtain threedimensional retinal thickness maps and microvascular images of the superficial and deep retinal capillary layers (SRCL and DRCL, respectively) around the macula. Quantitative analyses were performed using a custom automated algorithm. Results: The thicknesses of the nerve fiber layer, ganglion cell layer + inner plexiform layer, and ganglion cell complex (GCC) as well as the RCDs in the SRCL and DRCL in both TAO groups were significantly decreased compared to the controls. In addition, the RCDs in DRCL of the DON group were further decreased compared to the non-DON group. GCC thickness in both TAO groups was positively correlated with the RCDs of the SRCL in the total annular zone and in the temporal, inferior, and nasal sectors. The areas under the receiver operating characteristic curves for the GCC thickness combined with the RCD were generally larger than those of each single indicator. Conclusions: Thinned inner intra-retinal layers and decreased RCDs in the TAO patients without DON revealed that morphological changes might precede visual dysfunction. The composite index of the retinal structure and the microvascular density might be valuable in the diagnosing, monitoring, and intervention for early DON.

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“…In contrast to us, they have concluded that whole macular and parafoveal superficial vessel densities were significantly lower in the active TED compared with the control group. Ye L et al [45] used OCT-A imaging to characterize the retinal microvasculature in active TAO patients. eir results demonstrated that the macular and microvessel density was altered in both superficial and deep retinal layers, and vessel density may influence visual acuity.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy

Akpolat

Kurt

Yılmaz

et al. 2020

Journal of Ophthalmology

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Purpose. We aimed to evaluate foveal and parafoveal density using optical coherence tomography angiography and the alteration on the retinal vessel diameter in patients with inactive Graves’ ophthalmopathy compared to age-matched normal population. Materials and Methods. Patients with inactive Graves’ ophthalmopathy (study group) and healthy individuals (control group) were enrolled in the cross sectionally designed study. The optical coherence tomography angiography parameters and retinal vessel diameter measurements were assessed between the study and control groups. Foveal and parafoveal microvascular density in the retina was measured using optical coherence tomography angiography. Retinal artery and vein diameter and artery/vein ratio were assessed for retinal vessel caliber changes. Results. Patients with inactive Graves’ ophthalmopathy had higher values of intraocular pressure, proptosis, and axial length (P=0.001, P=0.002, and P=0.008, respectively). Temporal parafoveal vessel density was 48.93 ± 3.21 and 47.62 ± 2.59 in the study and control groups, respectively (P=0.017). Nasal parafoveal vessel density was 47.55 ± 3.01 and 46.46 ± 2.57 in the study and control groups, respectively (P=0.035). Foveal, superior, and inferior parafoveal vessel density values were similar in the study and control groups (P=0.268, P=0.107, and P=0.055, respectively). Patients in the study group had narrower retinal artery and vein diameters (P≤0.001 and P=0.033). Artery/vein ratio was significantly higher in the control group (P≤0.001). Conclusion. Optical coherence tomography angiography could be a novel and promising noninvasive diagnostic technique in patients with inactive Graves’ ophthalmopathy to detect foveal and parafoveal vessel density changes compared to healthy subjects. The decrease of retinal vessel diameter might be observed in patients with inactive graves ophthalmopathy.

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Retinal Microvasculature Alteration in Active Thyroid-Associated Ophthalmopathy

Cited by 62 publications

References 22 publications

Peripapillary and Macular Vessel Density in Dysthyroid Optic Neuropathy: An Optical Coherence Tomography Angiography Study

Peripapillary and Macular Vessel Density in Dysthyroid Optic Neuropathy: An Optical Coherence Tomography Angiography Study

Reduced macular inner retinal thickness and microvascular density in the early stage of patients with dysthyroid optic neuropathy

Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy

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