Retinal Morphologic Features in Patients with Large Macular Holes Treated by Autologous Neurosensory Retinal Transplantation

Kitahata, Shohei; Nagura, Koichi; Nakamura, Kentaro; Tanaka, Sanae; Inoue, Tatsuya; Maruyama-Inoue, Maiko; Kadonosono, Kazuaki

doi:10.1016/j.oret.2022.12.004

Ophthalmology Retina

2023

DOI: 10.1016/j.oret.2022.12.004

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Retinal Morphologic Features in Patients with Large Macular Holes Treated by Autologous Neurosensory Retinal Transplantation

Shohei Kitahata

Koichi Nagura

Kentaro Nakamura

et al.

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Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Kitahata et al . [ 22 ] divided patients with autologous retinal transplant into two groups depending on whether the EZ was restored or not. The group with restored EZ showed significantly greater improvement in the BCVA.…”

mentioning

confidence: 99%

Pathoanatomical aspects of macular hole closure: Emerging concepts

Saxena,

Singh,

Meyer

2023

Indian Journal of Ophthalmology

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mentioning

confidence: 99%

Pathoanatomical aspects of macular hole closure: Emerging concepts

Saxena,

Singh,

Meyer

2023

Indian Journal of Ophthalmology

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Temporal Changes in the Retinal Pigment Epithelium–Bruch's Membrane Complex Thickness After Autologous Retinal Transplantation in Myopic Eyes

Kitahata,

Inoue,

Tanaka

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Purpose To investigate the association between the thickness of the retinal pigment epithelium (RPE)–Bruch's membrane (BM) complex and the development of retinal autograft edema as a postoperative complication following autologous retinal transplantation (ART). Methods This retrospective study examined data from 28 eyes of 28 patients (14 males, 14 females; mean age, 61.5 ± 19.8 years) who underwent ART and were followed for 1 year. The RPE–BM complex thickness was measured 2000 µm from the fovea using Image J software. Additionally, the graft blood flow was also evaluated by optical coherence tomography angiography and fluorescein angiography. Results Macular hole (MH) diameters ranged from 711.2 ± 251.9 µm to 1299.9 ± 333.0 µm, with MH closure achieved in all patients. RPE–BM complex thickness decreased by 4.17 µm at 6 months and 4.34 µm at 1 year, showing significant differences from preoperative measurements (29.88 ± 4.99 µm; 6 months: 95% confidence interval [CI], 1.62–6.71, P = 0.0018; 1 year: 95% CI, 2.03–6.65 µm, P = 0.00044). The decrease was significantly greater in the edema-positive group (95% CI, –8.33 to –0.82, P = 0.020). Furthermore, the rates of ellipsoid zone (EZ) recovery, alignment of neurosensory layers (ANL), and graft reperfusion were lower in the edema-positive group (EZ, P = 0.017; ANL, P = 0.0098; reperfusion, P = 0.039). Conclusions After ART, RPE–BM complex thickness decreases, particularly in cases with postoperative edema, suggesting a potential relationship between RPE function and postoperative outcomes, highlighting the importance of monitoring RPE–BM complex thickness after surgery.

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Large macular hole and autologous retinal transplantation: a systematic review and meta-analysis

Hanai,

Amaral,

Jacometti

et al. 2024

Int J Retin Vitr

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Introduction Macular holes are breaks in the retinal tissue at the center of the macula, affecting central vision. The standard treatment involves vitrectomy with membrane peeling and gas tamponade. However, for larger or chronic holes, alternative techniques like autologous retinal graft have emerged. This meta-analysis evaluates the efficacy and safety of retinal transplantation in managing large macular holes. Methods We conducted a systematic review and meta-analysis following PRISMA guidelines. The study was prospectively registered in PROSPERO (CRD42024504801). We searched PubMed, Web of Science, Cochrane, and Embase databases for observational studies including individuals with large macular holes with or without retinal detachments and retinal transplantation as the main therapy. We used a random-effects model to compute the mean difference with 95% confidence intervals and performed statistical analysis using R software. Results We conducted a comprehensive analysis of 19 studies involving 322 patients diagnosed with various types of macular holes (MHs). These included cohorts with refractory MH, high myopia associated with MH, primary MH, and MH with retinal detachment (RD). The findings were promising, revealing an overall closure rate of 94% of cases (95% CI 88–98, I2 = 20%). Moreover, there was a significant improvement in postoperative visual acuity across all subgroups, averaging 0.45 (95% CI 0.33–0.58 ; I2 = 72%; p < 0.01) overall. However, complications occurred with an overall incidence rate of 15% (95% CI 7–25; I2 = 59%). Conclusion ART for large MH shows promising results, including significant improvements in visual acuity and a high rate of MH closure with low complication risks overall and for subgroups.

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Retinal Morphologic Features in Patients with Large Macular Holes Treated by Autologous Neurosensory Retinal Transplantation

Cited by 3 publications

References 26 publications

Pathoanatomical aspects of macular hole closure: Emerging concepts

Pathoanatomical aspects of macular hole closure: Emerging concepts

Temporal Changes in the Retinal Pigment Epithelium–Bruch's Membrane Complex Thickness After Autologous Retinal Transplantation in Myopic Eyes

Large macular hole and autologous retinal transplantation: a systematic review and meta-analysis

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