Retinal Nerve Fiber Layer Assessment by Scanning Laser Polarimetry and Standardized Photography

Niessen, A.G.J.E.; Berg, Thomas; Langerhorst, C. T.; Greve, E. L.

doi:10.1016/s0002-9394(14)75422-4

Cited by 76 publications

(35 citation statements)

References 19 publications

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“…Several investigations have reported that the reproducibility of measurements made by the NFA is generally better than that made by OCT [20, 21, 22, 23, 24, 25, 26, 27]. The results of this study are almost consistent with those of previous reports.…”

Section: Discussionsupporting

confidence: 91%

Comparison of the Effectiveness of Scanning Laser Polarimetry and Optical Coherence Tomography for Estimating Optic Nerve Fibre Layer Thickness in Patients with Glaucoma

Furuichi¹,

Kashiwagi²,

Furuichi³

et al. 2002

Ophthalmologica

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Purpose: The effectiveness of scanning laser polarimetry (by the nerve fibre analyser, NFA) and of optical coherence tomography (OCT) in estimating nerve fibre layer thickness (NFLT) and the correlations between NFLT and cup-to-disc (C/D) ratio or values of mean deviation (MD) from static visual field tests were compared using patients with glaucoma. Materials and Methods: Twenty-four eyes from 24 glaucoma patients were enrolled. The NFLT was measured along a circle with a diameter 1.5 times that of the optic disc around the optic disc. The averaged estimated NFLT of the circle or of each quadrantal NFLT (nasal, temporal, superior, inferior) was compared. Results: The co-variant indexes measured by the NFA were significantly smaller than those measured by OCT in both the averaged NFLT (p = 0.0002) and in each quadrantal NFLT (p < 0.05). The C/D ratio was significantly correlated with the averaged NFLT when measured by OCT (r = 0.425, p = 0.038), but not by the NFA (r = 0.179, p = 0.407). However, when measured by OCT, these values showed a significant correlation (r = 0.425, p = 0.039). Although both the OCT and NFA data showed significant correlations between NFLT and the MD (p = 0.0002 and p = 0.038, respectively), the OCT data showed a stronger correlation than did the NFA data (r = 0.677 and r = 0.422, respectively). The correlation between the averaged NFLTs obtained by NFA and OCT was not significant (r = 0.289, p = 0.172). Conclusion: OCT is thought to have an equal or better effectiveness for estimating NFLT, in spite of a lower reproducibility than that of the NFA.

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Section: Discussionsupporting

confidence: 91%

Comparison of the Effectiveness of Scanning Laser Polarimetry and Optical Coherence Tomography for Estimating Optic Nerve Fibre Layer Thickness in Patients with Glaucoma

Furuichi¹,

Kashiwagi²,

Furuichi³

et al. 2002

Ophthalmologica

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“…With a mean MD of ª9.0 dB and a mode MD of ª4.0 dB, the visual field defects were less advanced than those reported by Lemij et al (1997) and Niessen et al (1996).…”

Section: Glaucoma Materialscontrasting

confidence: 48%

Optic nerve head sector analysis recognizes glaucoma most effectively around disc poles

Gundersen

Heijl

Bengtsson

1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To analyze the topography of normal and glaucomatous discs with the goal of developing improved strategies to discriminate between normal and glaucomatous eyes. Subjects and methods: Raster tomography was performed in both eyes of 225 healthy subjects and in 296 eyes of 214 glaucoma patients. Cup area, average cup radius, rim area and minimal rim width were measured in 24 sectors around the optic nerve head at nine different depths from the reference plane. Receiver Operating Curves (ROC) for numerous combinations of parameter, sector and depth were calculated and compared. Results: Discrimination between glaucomatous and normal eyes varied widely between single sectors of the optic disc, and was best at the vertical poles of the disc, intermediate in nasal sectors and worst in temporal sectors. When single sectors or combinations of sectors at the superior pole were combined with their counterparts at the inferior pole of the optic nerve, the gain in sensitivity exceeded the loss in specificity, and discrimination improved. Separation declined dramatically if any of the 8 temporal sectors were involved in such analysis. Depth influenced discrimination only slightly. Conclusion: Single sectors located close to the vertical meridian yielded better discrimination than global measurements. When two or more sectors at the superior pole were combined with each other, as well as with their counterparts at the inferior pole, discrimination improved even further. Localized changes concurred frequently, but asymmetrically at both poles of the disc. The depth from reference plane used to define the cup was not critical for separation between normal and glaucomatous eyes.

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“…According to Airaksinen et al (1985Airaksinen et al ( , 1986, the degree of RNFL loss, assessed semiquantitatively, showed a strong correlation with Octopus visual field indices as well as with disorders of Discussion yellow-blue and green-blue color vision, detected bv use of an anomaloscope in The extent to which morphological changes in the RNFL are correlated with functional deficits that are detectable by tests such as perimetry in patients with glaucoma is unclear (Airaksinen et al glaucoma. <Thickness of the RNFL as determined by scanning laser polarimetry in patients with glaucoma is significantly correlated with the loss in visual field, as measured by conventional dif- fential light sensitivity perimetry (Niessen et al 1996;Shirakashi et al 1996;Weinreb et al 1995b). Although several investigators have reported a significant correlation between the indices of high-pass resolution perimetry and optic disc topography in glaucomatous eyes (Airaksinen et al 1990;Lachenmayr et al 1991;Tomita et al 1993), others were not able to confirm any correlation (Chauhan et a].…”

Section: Resultsmentioning

confidence: 99%

Measurement of thickness of retinal nerve fiber layer by scanning laser polarimetry and high‐pass resolution perimetry in patients with primary open‐angle or normal‐tension glaucoma

Shirakashi

Abe

Sawaguchi

et al. 1997

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To evaluate the correlation between neural capacity, determined by high-pass resolution perimetry, and thickness of the retinal nerve fiber layer, evaluated by scanning laser polarimetry, in patients with primary open-angle glaucoma or normal-tension glaucoma. Metho&: Thickness ofthe peripapillary retinal nerve fiber layer was measured by scanning laser polapimetry in 19 eyes of 19 patients with primary open-angle glaucoma and in 23 eyes of 23 patients with normal-tension glaucoma. There were no significant differences between the two groups in mean age, sex ratio, or mean neural capacity. Results: Neural capacity was significantly correlated with thickness of the retinal nerve fiber layer in all 42 eyes (r = 0.31, P = 0.0429). Neural capacity was significantly correlated with thickness of the retinal nerve fiber layer in the eyes of patients with primary open-angle glaucoma (r = 0.60, P = 0.0061), but not in the eyes of patients with normal-tension glaucoma (r = 0.04; P = 0.8522). Conclusion:The degree of correlation between neural capacity determined by high-pass resolution perimetry and thickness of the retinal nerve fiber layer measured by scanning laser polarimetry appeared to differ in patients with primary open-angle glaucoma vs those with normal-tension glaucoma.

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Retinal Nerve Fiber Layer Assessment by Scanning Laser Polarimetry and Standardized Photography

Cited by 76 publications

References 19 publications

Comparison of the Effectiveness of Scanning Laser Polarimetry and Optical Coherence Tomography for Estimating Optic Nerve Fibre Layer Thickness in Patients with Glaucoma

Comparison of the Effectiveness of Scanning Laser Polarimetry and Optical Coherence Tomography for Estimating Optic Nerve Fibre Layer Thickness in Patients with Glaucoma

Optic nerve head sector analysis recognizes glaucoma most effectively around disc poles

Measurement of thickness of retinal nerve fiber layer by scanning laser polarimetry and high‐pass resolution perimetry in patients with primary open‐angle or normal‐tension glaucoma

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