Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography

Leung, Christopher Kai-Shun; Yu, Marco; Weinreb, Robert N.; Ye, Cong; Liu, Shu; Lai, Gilda; Lam, Dennis S C

doi:10.1016/j.ophtha.2011.10.010

Cited by 217 publications

(104 citation statements)

References 35 publications

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“…35, 36 These eyes were generally those with relatively higher IOP during follow-up. For example, even among eyes that were declared as non-progressing by SAP GPA™, those with average IOP of approximately 25 mmHg had a mean rate of change of −0.97 µm/year during follow-up, which is almost two times faster than the expected age-related loss.…”

Section: Discussionmentioning

confidence: 98%

Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography

et al. 2016

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Purpose To evaluate the relationship between intraocular pressure (IOP) and rates of retinal nerve fiber layer (RNFL) thickness change over time measured by spectral-domain (SD) optical coherence tomography (OCT). Design Observational cohort study. Participants The study involved 547 eyes of 339 patients followed for an average period of 3.9 ± 0.9 years. Three hundred and eight (56.3%) had a diagnosis of glaucoma and 239 (43.7%) were considered glaucoma suspects. Methods All eyes underwent imaging using the Spectralis® SD OCT (Heidelberg Engineering GmbH, Heidelberg, Germany), along with IOP measurements and standard automated perimetry (SAP). Glaucoma progression was defined as a result of “Likely Progression” from the Guided Progression Analysis™ software for SAP. Linear mixed models were used to investigate the relationship between average IOP during follow-up and rates of RNFL thickness change, while taking into account potential confounding factors, such as age, race, corneal thickness, and baseline disease severity. Main Outcome Measures The association between IOP and rates of global and sectorial RNFL thickness loss measured by SD OCT. Results Forty-six eyes (8.4%) showed progression on SAP during follow-up. Rates of global RNFL thickness change in eyes that progressed by SAP were faster than in those that did not progress (−1.02 µm/year versus −0.61 µm/year, respectively; P = 0.002). For progressing eyes, each 1 mmHg higher average IOP during follow-up was associated with an additional average loss of 0.20 µm/year [confidence interval (CI): 0.08 to 0.31 µm/year; P < 0.001] of global RNFL thickness versus only 0.04 µm/year (CI: 0.01 to 0.07 µm/year; P = 0.015) for non-progressing eyes. The largest associations between IOP and rates of RNFL change were seen for measurements from the temporal superior and temporal inferior sectors, whereas the smallest association was seen for measurements from the nasal sector. Conclusions Higher levels of IOP during follow-up were associated with faster rates of RNFL loss over time measured by SD OCT. These findings support the use of SD OCT RNFL thickness measurements as biomarkers for the evaluation of the efficacy of IOP-lowering therapies to slow down the rate of disease progression.

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Section: Discussionmentioning

confidence: 98%

Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography

et al. 2016

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“…It is well recognized that the RNFL thickness is reduced in glaucoma patients 32 and higher-age subjects. 33 The optical intensity of RNFL was also reported to be lower in patients with glaucoma compared to normal controls or subjects with ocular hypertension. 8,9 Our study was the first to show an age-dependent loss of RNFL intensity.…”

Section: Discussionmentioning

confidence: 98%

Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography

Chen

Hou

Jin

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Citation: Chen X, Hou P, Jin C, et al. Quantitative analysis of retinal layer optical intensities on three-dimensional optical coherence tomography. Invest Ophthalmol Vis Sci. PURPOSE.To investigate the optical intensities of all retinal layers on three-dimensional (3D) spectral-domain optical coherence tomography (SD-OCT) in normal subjects using an automatic measurement. METHODS.Forty normal subjects underwent Topcon 3D OCT-1000 macula-centered scan. The raw data were automatically segmented into 10 layers using the 3D graph search approach. Then the mean and standard deviation of intensities of each layer were calculated. The image quality index was given by the OCT software. Correlation analysis was performed between the optical intensities in each layer and image quality and subject's age.RESULTS. The correlation of optical intensities was strong from ganglion cell layer (GCL) to outer nuclear layer (ONL) with r > 0.934; moderate among retinal nerve fiber layer (RNFL), photoreceptor, retinal pigment epithelium (RPE), and choroid (0.410 < r < 0.800); and low in the vitreous (0.251 < r < 0.541). The optical intensities were also correlated with the image quality, r > 0.869 from GCL to ONL, 0.748 < r < 0.802 for RNFL, photoreceptor layer, RPE, and the choroid, r ¼ 0.528 for the vitreous. The optical intensity in RNFL was negatively correlated with age (r ¼ À0.365).CONCLUSIONS. Automatic assessment of the layers' intensities was achieved. In normal subjects, the retinal layers' optical intensities were affected by image quality. Normalization with optical intensity of ONL, all areas, or image quality index is recommended. The optical intensity of RNFL decreased with age.

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“…Additionally, the Cirrus GPA printout also presents evaluation of changes in the RNFLT profile (arrow, dashed line), and trend analyses of average and sectoral indexes (black arrows). Medeiros et al, 2009;Miki et al, 2014;Wessel et al, 2013), healthy subjects also have significant age-related loss of RNFLT (Leung et al, 2012). There is no consensus on thresholds to separate age-related decline from glaucoma progression.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

How to detect progression in glaucoma

Vianna

Chauhan

2015

Progress in Brain Research

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Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography

Cited by 217 publications

References 35 publications

Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography

Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography

Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography

How to detect progression in glaucoma

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