Retinal Oxalosis

Wells, Craig G.; Johnson, Richard J.; Luo, Qingli; Bunt-Milam, Ann H.; Kalina, Robert E.

doi:10.1001/archopht.1989.01070020716035

Cited by 40 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is no known gold standard diagnostic test and without a positive control, no screening test has been developed. Manifestations of oxalosis were often detected based on clinical suspicion [16,[27][28][29][30][31] and we know of no recent reports of secondary oxalosis in ESRD patients on dialysis, even though the vast majority of prevalent HD patients have an abnormal pre-HD P[Ox]. While we cannot conclusively say that our patients did not have secondary oxalosis, this condition may be extremely rare, or even nonexistent.…”

Section: Discussionsupporting

confidence: 45%

Plasma oxalate levels in prevalent hemodialysis patients and potential implications for ascorbic acid supplementation

Yu-guan

Weisberg

Langman

et al. 2016

Clinical Biochemistry

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 45%

Plasma oxalate levels in prevalent hemodialysis patients and potential implications for ascorbic acid supplementation

Yu-guan

Weisberg

Langman

et al. 2016

Clinical Biochemistry

View full text Add to dashboard Cite

“…Oxalate may accumulate in renal failure, as the kidney is the major route of oxalate removal from the body. Oxalate crystals can deposit in various tissues such as the retina, skin, joints, muscle, and myocardium (44)(45)(46)(47)(48)(49). In vitro, oxalate crystallization may occur at levels above 30 lmol ⁄ l (normal range in plasma: 2-8 lmol ⁄ l).…”

Section: Oxalosismentioning

confidence: 99%

“…The ability of current dialysis technology to clear oxalate is well documented (55). However, in patients who were treated with older forms of dialysis technology, there were several case reports of oxalate deposits in various tissues of patients following sustained very high intake of vitamin C (often self prescribed, at levels of 1-2 g ⁄ day) (45)(46)(47)49,56,57). These reports, which, in some cases, showed serious side effects of oxalate deposition, led to clinical recommendations that vitamin C supplementation in dialysis patients to be limited to a conservative range of 60-100 mg ⁄ day.…”

Section: Oxalosismentioning

confidence: 99%

Is Vitamin C Intake too Low in Dialysis Patients?

Raimann

Levin

Craig

et al. 2012

Seminars in Dialysis

View full text Add to dashboard Cite

Vitamin C has several well-established roles in physiology including synthesis of collagen, carnitine and epinephrine, absorption of dietary iron, and mobilization of storage iron for erythropoeisis. Loss of several of these functions explains the pathology of scurvy, where defective collagen synthesis and anemia are major symptoms. Vitamin C deficiency is very common in dialysis patients and may arise from dialytic vitamin C clearance, restricted intake of vitamin C-rich foods, and increased vitamin C catabolism in vivo from inflammation. In the dialysis population, greater vitamin C intake may be needed for optimal health. Relationships between intake, body distribution, inflammation, and dialytic losses are complex and need further study. Concern about vitamin C metabolism leading to accumulation of tissue oxalate has led to the recommendation that vitamin C intake equals, but not exceeds, the intake recommended for the general population. Vitamin C deficiency in dialysis patients may have clinical consequences; a study in Renal Research Institute clinics found an association with periodontal disease. Data also support a role for vitamin C in prevention of dialysis-related anemia. New research questions are proposed in this editorial, with a discussion of strategies to determine the optimal provision of vitamin C for CKD patients.

show abstract

“…Histologically, deposits are seen in the inner retina and RPE. 443,444 Talc See above in the Vascular Related section.…”

Section: Diagnostic Testingmentioning

confidence: 99%

The Impact of Systemic Medications on Retinal Function

Somisetty

Santina

Sarraf

et al. 2023

Asia-Pacific Journal of Ophthalmology

View full text Add to dashboard Cite

This study will provide a thorough review of systemic (and select intravitreal) medications, along with illicit drugs that are capable of causing various patterns of retinal toxicity. The diagnosis is established by taking a thorough medication and drug history, and then by pattern recognition of the clinical retinal changes and multimodal imaging features. Examples of all of these types of toxicity will be thoroughly reviewed, including agents that cause retinal pigment epithelial disruption (hydroxychloroquine, thioridazine, pentosan polysulfate sodium, dideoxyinosine), retinal vascular occlusion (quinine, oral contraceptives), cystoid macular edema/retinal edema (nicotinic acid, sulfa-containing medications, taxels, glitazones), crystalline deposition (tamoxifen, canthaxanthin, methoxyflurane), uveitis, miscellaneous, and subjective visual symptoms (digoxin, sildenafil). The impact of newer chemotherapeutics and immunotherapeutics (tyrosine kinase inhibitor, mitogen-activated protein kinase kinase, checkpoint, anaplastic lymphoma kinase, extracellular signal-regulated kinase inhibitors, and others), will also be thoroughly reviewed. The mechanism of action will be explored in detail when known. When applicable, preventive measures will be discussed, and treatment will be reviewed. Illicit drugs (cannabinoids, cocaine, heroin, methamphetamine, alkyl nitrite), will also be reviewed in terms of the potential impact on retinal function.

show abstract

Retinal Oxalosis

Cited by 40 publications

References 33 publications

Plasma oxalate levels in prevalent hemodialysis patients and potential implications for ascorbic acid supplementation

Plasma oxalate levels in prevalent hemodialysis patients and potential implications for ascorbic acid supplementation

Is Vitamin C Intake too Low in Dialysis Patients?

The Impact of Systemic Medications on Retinal Function

Contact Info

Product

Resources

About