Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease

Jacob, Ninan; Tyagi, Mudit; Chhablani, Jay; Narayanan, Raja; Kelgaonkar, Anup; Jain, Mukesh; Singh, Sumit Randhir; Sahoo, Niroj Kumar

doi:10.3390/jcm12062368

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Jacob et al previously tried to evaluate the RPE reflectivity in eyes with VKH disease and reported an increase in RPE reflectivity during the resolution of VKH, 32 which differed from the results presented in our manuscript. The differences in our findings can be attributed to several factors.…”

Section: Discussioncontrasting

confidence: 99%

Association of Retinal Pigment Epithelium Reflectivity on Optical Coherence Tomography with Recurrence of Vogt–Koyanagi–Harada Disease: A Retrospective Observational Study

Hirota¹,

Muraoka²,

Kogo³

et al. 2023

OPTH

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Despite the necessity of optical coherence tomography (OCT) for diagnosis and longitudinal monitoring in patients with Vogt-Koyanagi-Harada (VKH) disease, no studies have identified useful OCT markers for predicting recurrence in these patients. Although the precise reason for this remains unclear, one possibility is that infiltration of inflammatory cells into the choroid attenuates the OCT signal, making it difficult to precisely assess the structure of the choroid. Therefore, this study aimed to investigate changes in retinal pigment epithelium (RPE) reflectivity immediately above the choroid in eyes with acute VKH disease, as well as the association between RPE reflectivity and VKH disease recurrence. Patients and Methods: This single-centered retrospective observational study included 20 treatment-naïve patients with acute VKH disease presenting with serous retinal detachment (SRD) in the posterior pole at the initial visit between October 2015 and January 2020, as well as 15 healthy control eyes. All patients were followed up for at least 6 months and received treatment with intravenous methylprednisolone followed by oral administration of prednisolone. Swept-source OCT images through the fovea were used to measure central retinal thickness, central choroidal thickness, and RPE reflectivity. Results: During an observation period of 37.2 ± 30.8 months, recurrence of inflammation was observed in 11 patients (55.0%). Initial visual acuity was worse in patients who developed recurrence than in those who did not (P=0.024). On initial OCT images, RPE reflectivity differed significantly between patients with and without recurrence (1.75 ± 0.42 vs 1.35 ± 0.20; P=0.018), while there were no significant differences in other chorioretinal parameters, such as central retinal thickness and choroidal thickness. Conclusion: RPE reflectivity on OCT images may be useful for predicting the recurrence of inflammation in patients with VKH disease.

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Section: Discussioncontrasting

confidence: 99%

Association of Retinal Pigment Epithelium Reflectivity on Optical Coherence Tomography with Recurrence of Vogt–Koyanagi–Harada Disease: A Retrospective Observational Study

Hirota¹,

Muraoka²,

Kogo³

et al. 2023

OPTH

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“…Such a procedure has already been used and validated. 13,14 Using this software, we measured two parameters at the level of these territories: the vessels percentage area and the average vessels length. We compared these values with those of a territory of the same mirrored surface about the horizontal meridian.…”

Section: Optical Coherence Tomography Analysismentioning

confidence: 99%

Atypical Foveal and Parfoveal Abnormalities in Sickle Cell Disease

Orssaud,

Flammarion,

Michon

et al. 2023

Retina

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Purpose: The primary aim was to describe patterns of para macular involvement, not yet reported but that OCT-A can now detect in SCD patients. The secondary aim was to search arguments concerning the physio pathogeny of para macular involvement. Methods: This institutional cohort retrospective study was conducted in a Referral Center for Ophthalmological Rare Diseases. Follow-up included an ophthalmological examination with optical coherent tomography and optical coherent tomography angiography. Results: Hundred and thirty-two sickle cell patients were included. Typical sickle cell maculopathy was observed in temporal area in 84 eyes (40.0 %) of SS patients and 8 eyes (14.8 %) of SC patients (p < 0.001). Enlargement of the foveal avascular zone was observed in 10 eyes whom 8 of SS patients. Two atypical parafoveal abnormalities were found in SS patients only. The first one consisted in macular thinning with normal vascularization in 15 eyes of 11 patients. The second atypical maculopathy was large areas of loss of vascularization without retina thinning 10 eyes of six patients. Multivariate analysis did not show a statistically significant relation between the PSR stage and the different type of sickle cell maculopathy (p = 0.21) Conclusion: Those atypical sickle cell maculopathy may correspond to early forms preceding a typical SCM. This would point towards several physiopathogenic mechanisms. The first one included the existence of ischemia which can be related to anemia. Presence of retinal thinning without vascular involvement point out to a neurogenic mechanism.

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“…[ 4 , 5 ] The retinal pigment epithelium (RPE) is a monolayer of pigment cells that is involved in the pathological process of VKH disease. [ 6 , 7 , 8 , 9 ] Long‐held theories suggest that the symptoms of VKH disease may be caused by an autoimmune response to melanin. [ 4 , 7 ] In the early stage of VKH disease, human melanoma cells are severely affected by T cells, presenting as folds of RPE.…”

Section: Introductionmentioning

confidence: 99%

OR11H1 Missense Variant Confers the Susceptibility to Vogt‒Koyanagi‒Harada Disease by Mediating Gadd45g Expression

Li,

Wang,

Wang

et al. 2024

Advanced Science

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Vogt‒Koyanagi‒Harada (VKH) disease is a severe autoimmune disease. Herein, whole‐exome sequencing (WES) study are performed on 2,573 controls and 229 VKH patients with follow‐up next‐generation sequencing (NGS) in a collection of 2,380 controls and 2,278 VKH patients. A rare c.188T>C (p Val63Ala) variant in the olfactory receptor 11H1 (OR11H1) gene is found to be significantly associated with VKH disease (rs71235604, Pcombined = 7.83 × 10−30, odds ratio = 3.12). Functional study showes that OR11H1‐A63 significantly increased inflammatory factors production and exacerbated barrier function damage. Further studies using RNA‐sequencing find that OR11H1‐A63 markedly increased growth arrest and DNA‐damage‐inducible gamma (GADD45G) expression. Moreover, OR11H1‐A63 activates the MAPK and NF‐κB pathways, and accelerates inflammatory cascades. In addition, inhibiting GADD45G alleviates inflammatory factor secretion, likely due to the regulatory effect of GADD45G on the MAPK and NF‐κB pathways. Collectively, this study suggests that the OR11H1‐A63 missense mutation may increase susceptibility to VKH disease in a GADD45G‐dependent manner.

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Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease

Cited by 4 publications

References 17 publications

Association of Retinal Pigment Epithelium Reflectivity on Optical Coherence Tomography with Recurrence of Vogt–Koyanagi–Harada Disease: A Retrospective Observational Study

Association of Retinal Pigment Epithelium Reflectivity on Optical Coherence Tomography with Recurrence of Vogt–Koyanagi–Harada Disease: A Retrospective Observational Study

Atypical Foveal and Parfoveal Abnormalities in Sickle Cell Disease

OR11H1 Missense Variant Confers the Susceptibility to Vogt‒Koyanagi‒Harada Disease by Mediating Gadd45g Expression

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