Retinal pigment epithelial damage, breakdown of the blood–retinal barrier, and retinal inflammation in dogs with primary glaucoma

Mangan, Brendan G.; Alyahya, Khaleel; Chen, Chu-Te; Gionfriddo, Juliet R.; Powell, Cynthia C.; Dubielzig, Richard R.; Ehrhart, E. J.; Madl, James E.

doi:10.1111/j.1463-5224.2007.00585.x

Cited by 31 publications

(25 citation statements)

References 25 publications

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“…However, little is known as to whether RNFL damage, which has been demonstrated to correlate with visual field function,7,26,37 is connected with RPE malfunction or degeneration potentially detectable by FAF. Our observations of a certain correlation between sectoral RNFL thickness and FAF intensity at corresponding locations in glaucomatous eyes are in accordance with published studies on dogs and reveal a close interaction between RPE and the neurosensory retina 12. The results of this study provide early evidence that peripapillary RNFL degeneration in glaucoma patients may be accompanied by corresponding RPE alterations.…”

Section: Discussionsupporting

confidence: 92%

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Correlation between peripapillary retinal nerve fiber layer thickness and fundus autofluorescence in primary open-angle glaucoma

Reznicek¹,

Seidensticker²,

Mann³

et al. 2013

OPTH

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PurposeTo investigate the relationship between retinal nerve fiber layer (RNFL) thickness and retinal pigment epithelium alterations in patients with advanced glaucomatous visual field defects.MethodsA consecutive, prospective series of 82 study eyes with primary open-angle glaucoma and advanced glaucomatous visual field defects were included in this study. All study participants underwent a full ophthalmic examination followed by visual field testing with standard automated perimetry as well as spectral-domain optical coherence tomography (SD-OCT) for peripapillary RNFL thickness and Optos wide-field fundus autofluorescence (FAF) images. A pattern grid with corresponding locations between functional visual field sectors and structural peripapillary RNFL thickness was aligned to the FAF images at corresponding location. Mean FAF intensity (range: 0 = black and 255 = white) of each evaluated sector (superotemporal, temporal, inferotemporal, inferonasal, nasal, superonasal) was correlated with the corresponding peripapillary RNFL thickness obtained with SD-OCT.ResultsCorrelation analyses between sectoral RNFL thickness and standardized FAF intensity in the corresponding topographic retina segments revealed partly significant correlations with correlation coefficients ranging between 0.004 and 0.376 and were statistically significant in the temporal inferior central field (r = 0.324, P = 0.036) and the nasal field (r = 0.376, P = 0.014).ConclusionRetinal pigment epithelium abnormalities correlate with corresponding peripapillary RNFL damage, especially in the temporal inferior sector of patients with advanced glaucomatous visual field defects. A further evaluation of FAF as a potential predictive parameter for glaucomatous damage is necessary.

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Section: Discussionsupporting

confidence: 92%

“…A previously published study on dogs has shown pathologic abnormalities and RPE damage in glaucomatous eyes 12. Few published studies on human glaucomatous eyes have shown correlations between peripapillary RPE abnormalities and optic nerve degeneration in glaucoma patients 13–15.…”

Section: Introductionmentioning

confidence: 99%

Correlation between peripapillary retinal nerve fiber layer thickness and fundus autofluorescence in primary open-angle glaucoma

Reznicek¹,

Seidensticker²,

Mann³

et al. 2013

OPTH

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“…Similarly, mononuclear cells have been identified in the retina and posterior segment of the affected eye in dogs that have undergone enucleation because of GDRG but not in the eyes of clinically normal control dogs. 34 Changes in expression of inflammation-related genes have also been detected in glaucomatous retinas of dogs. 35 …”

Section: Discussionmentioning

confidence: 99%

Western blot patterns of serum autoantibodies against optic nerve antigens in dogs with goniodysgenesis-related glaucoma

Pumphrey

Pizzirani²,

Pirie³

et al. 2013

ajvr

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Objective To investigate whether differences existed between clinically normal dogs and dogs with goniodysgenesis-related glaucoma (GDRG) in serum autoantibodies against optic nerve antigens. Animals 16 dogs with GDRG, 17 healthy dogs with unremarkable pectinate ligament and iridocorneal angle morphology, and 13 euthanized dogs with no major ocular abnormalities or underlying diseases. Procedures Western blotting was performed with optic nerve extracts from the euthanized dogs as an antigen source and serum from clinically normal dogs and dogs with GDRG as a primary antibody (autoantibody) source. Blots were evaluated for presence and density of bands. Results Multiple bands were identified on western blots from all dogs with GDRG and all clinically normal dogs, with a high degree of variability among individual dogs. Dogs with GDRG were significantly more likely than healthy dogs to have bands present at 38, 40, and 68 kDa. Dogs with GDRG had significant increases in autoreactivity at 40 and 53 kDa and a significant decrease in autoreactivity at 48 kDa. Conclusions and Clinical Relevance Significant differences in serum autoantibodies against optic nerve antigens were found in dogs with versus without GDRG. Although it remains unclear whether these differences were part of the pathogenesis of disease or were sequelae to glaucomatous changes, these findings provide support for the hypothesis that immune-mediated mechanisms play a role in the development or progression of GDRG. However, the high degree of variability among individual dogs and the considerable overlap between groups suggest that the clinical usefulness of this technique for distinguishing dogs with GDRG from clinically normal dogs is likely limited.

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“…1,3,134,139,145 The disease has been studied most thoroughly in American and English cocker spaniels, 128,129,[146][147][148][149][150][151][152] basset hound, 26,27,[127][128][129]146,[150][151][152][153][154] English and Welsh springer spaniels, 9,131 Bouvier des Flandres, 142,149 Chow Chow, 152,155 Siberian husky, 152 Great Dane, 132 flat-coated retriever, 143,156,157 Samoyed, [11][12][13] Shiba inu, 19,21,130,145 Shih Tzu, 21,145 Eurasier dog (created from Chow Chow and Samoyed), 141 Dandie Dinmont terrier, 28 and golden retriever. 158 Despite the proposed autosomal-dominant and autosomal-recessive inheritance of PACG in the Welsh springer spaniel 131 and Siberian husky, …”

Section: Genetics Of Canine Primary Angle-closure Glaucomamentioning

confidence: 99%

Genetics of Canine Primary Glaucomas

Komàromy

Petersen‐Jones

2015

Veterinary Clinics of North America: Small Animal Practice

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Retinal pigment epithelial damage, breakdown of the blood–retinal barrier, and retinal inflammation in dogs with primary glaucoma

Cited by 31 publications

References 25 publications

Correlation between peripapillary retinal nerve fiber layer thickness and fundus autofluorescence in primary open-angle glaucoma

Correlation between peripapillary retinal nerve fiber layer thickness and fundus autofluorescence in primary open-angle glaucoma

Western blot patterns of serum autoantibodies against optic nerve antigens in dogs with goniodysgenesis-related glaucoma

Genetics of Canine Primary Glaucomas

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