Retinal pigment epithelium adenoma in vitreous fluid cytology

John, Sandhya; Lew, Madelyn

doi:10.1002/dc.23781

Cited by 3 publications

(8 citation statements)

References 8 publications

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“…Disadvantages include diffusion of the tumour cells along the needle tract, intraocular bleeding and retina hole, inadequate material, and the need for experienced hands [37]. John and Lew [39] reported RPE adenomas displaying round cells with eccentrically placed nuclei and abundant granular cytoplasm with or without vacuolations. Usually, mild nuclear pleomorphism, rare mitoses, and large melanosomes are present.…”

Section: Fine-needle Aspiration Biopsymentioning

confidence: 99%

“…Usually, mild nuclear pleomorphism, rare mitoses, and large melanosomes are present. In cases with more cellular atypia, RPE adenocarcinoma may be Ocul Oncol Pathol 2021;7:121-132 DOI: 10.1159/000509484 considered [39]. However, cytology alone cannot differentiate between RPE adenomas and adenocarcinomas [39].…”

Section: Fine-needle Aspiration Biopsymentioning

confidence: 99%

“…In cases with more cellular atypia, RPE adenocarcinoma may be considered [39]. However, cytology alone cannot differentiate between RPE adenomas and adenocarcinomas [39].…”

Section: Literature Reviewmentioning

confidence: 99%

“…One case report mentioned spindle-shaped cells [26]. The cells usually have abundant cytoplasm containing variable-sized melanin granules, exhibit mild nuclear pleomorphism, and have prominent nucleoli and few mitoses [16, 21, 24, 39, 41]. The tumour cells usually rest on periodic acid Schiff (PAS)-positive extracellular matrix [17, 18, 33, 34, 37].…”

Section: Literature Reviewmentioning

confidence: 99%

“…Tso and Albert [1] described 4 patterns in which the tumour cells may be arranged, namely, mosaic (resembling normal RPE), tubular, a patternless arrangement of vacuolated cells, and a patternless arrangement of anaplastic cells. Tumours arising from the anterior RPE (and ciliary body) tend to have a vacuolated pattern, and those located posteriorly show a glandular or tubular configuration [2, 37, 39]. Font et al [42] discovered by means of histochemistry that secretory intracellular vacuoles of tumour cells contained sialomucin; they hence stated the possibility of normal RPE contributing a small quantity of sialomucin to the inter-receptor mucoid.…”

Section: Literature Reviewmentioning

confidence: 99%

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Retinal Pigment Epithelium Adenoma and Adenocarcinoma: A Review

et al. 2020

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Adenoma and adenocarcinoma of the retinal pigment epithelium (RPE) are rare intraocular tumours that are often misdiagnosed as posterior uveal melanoma or other simulating lesions. It is important to be able to differentiate these tumours from melanoma for 3 reasons. First, an inability to rule out melanoma often tilts the management towards enucleation. Second, management options like radiotherapy and local resection which work well for melanoma may not be easily applied to these tumours. Third, and most importantly, patients with melanoma need a lifetime follow-up to rule out metastases (metastatic dormancy) whereas RPE tumours hardly metastasize. An abruptly elevated, often deeply pigmented tumour, with a prominent retinal feeding artery and a draining vein causing exudation, should raise a suspicion of RPE tumours. RPE tumours have a remarkable local invasive potential but a low metastatic potential. Most RPE tumours require treatment due to local complications. Small, asymptomatic tumours can be generally observed. Enucleation is still the gold standard of treatment, although local resection has been reported in selected cases with good results. Here, we provide a comprehensive review of the demographic, clinical, and imaging features of true acquired neoplasms of the RPE, namely adenoma and adenocarcinoma, the ways to differentiate them from melanoma, their clinical course and prognosis, and Options for their management.

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Section: Fine-needle Aspiration Biopsymentioning

confidence: 99%

Section: Fine-needle Aspiration Biopsymentioning

confidence: 99%

“…In cases with more cellular atypia, RPE adenocarcinoma may be considered [39]. However, cytology alone cannot differentiate between RPE adenomas and adenocarcinomas [39].…”

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

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Retinal Pigment Epithelium Adenoma and Adenocarcinoma: A Review

et al. 2020

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Nonpigmented Adenoma of the Retinal Pigment Epithelium Mimicking a Retinal Vasoproliferative Tumor Managed With Endoresection

Coussa,

Mansoor,

Boldt

et al. 2024

Journal of VitreoRetinal Diseases

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Purpose: To present a case with signs suggestive of a retinal vasoproliferative tumor. Methods: A case report was evaluated and a surgical video presented. Results: A 61-year-old White man presented with an amelanotic retinal tumor associated with exudation, retinal edema, and overlying telangiectatic vessels, suggestive of a retinal vasoproliferative tumor. Standardized echography showed an irregular mass with medium-to-high internal reflectivity and internal calcification, which suggested chronicity. He was initially treated for an exudative retinal detachment (RD) in the context of a presumed vasoproliferative tumor but later developed combined exudative and rhegmatogenous RD, prompting surgical repair with tumor endoresection. Pathology showed nonpigmented adenoma of the retinal pigment epithelium (RPE). Conclusions: Nonpigmented adenoma of the RPE is a rare tumor, and its clinical similarity to a vasoproliferative tumor should be noted. Endoresection may be considered in cases resulting in RD.

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Consultations in Eye Pathology: Experience at an Ophthalmology Specialty Hospital

Milman

Martinez

Calotti

et al. 2023

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Ophthalmic pathology is a discipline that relies heavily on a knowledge of clinical ophthalmology. The diagnosis of ocular and periocular lesions can be challenging because some lesions and diseases are unique to this region, whereas others may demonstrate site-specific differences from nonocular counterparts. Because of these challenges, ocular and periocular biopsies are frequently referred to specialized ophthalmic pathology centers for second opinion diagnoses. Objective.— To analyze the referral patterns, diagnostic challenges, and diagnostic discrepancies for second opinion referrals at a dedicated ophthalmic pathology laboratory with an emphasis on lesions of special interest in ophthalmic pathology. Data Sources.— Data sources included the pathology records of all slides and blocks received in consultation at the referral eye pathology center between December 1, 2015, and December 1, 2022, the personal experience of senior authors, and published peer-reviewed literature. Conclusions.— Corneal, intraocular, and conjunctival biopsies are the most common types of cases received in consultation without the referring pathologist's diagnosis, likely reflecting diagnostic challenges. Degenerative intraocular processes occasionally raise concern for a neoplasm. Conjunctival melanocytic lesions are the most common conjunctival biopsies referred for second opinion diagnosis and require careful tissue sampling and clinical-pathologic correlation. Careful clinical-pathologic correlation, a high level of suspicion, and adequate sampling also are required for the accurate diagnosis of periocular sebaceous carcinoma. The diagnostic discrepancies involving uveal, retinal, conjunctival, eyelid, and temporal artery biopsies are most likely to adversely influence patient management and possible outcome. Such specimens may benefit from referral to specialized ophthalmic pathology laboratories.

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Retinal pigment epithelium adenoma in vitreous fluid cytology

Cited by 3 publications

References 8 publications

Retinal Pigment Epithelium Adenoma and Adenocarcinoma: A Review

Retinal Pigment Epithelium Adenoma and Adenocarcinoma: A Review

Nonpigmented Adenoma of the Retinal Pigment Epithelium Mimicking a Retinal Vasoproliferative Tumor Managed With Endoresection

Consultations in Eye Pathology: Experience at an Ophthalmology Specialty Hospital

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