Retinal projections and neurochemical characterization of the pregeniculate nucleus of the common marmoset (Callithrix jacchus)

Lima, Ruthnaldo Rodrigues Melo de; Pinato, Luciana; Nascimento, Rayane Bartira Silva do; Engelberth, Rovena Clara Galvão Januário; Nascimento, Expedito Silva do; Cavalcante, Judney Cley; Britto, Luiz Roberto Giorgetti de; Costa, Miriam S.M.O.

doi:10.1016/j.jchemneu.2012.04.001

Cited by 16 publications

(17 citation statements)

References 49 publications

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“…PIm and SC injections (F1747, M1923, and M1551; Table ) also revealed retrograde‐labeled cell bodies and terminals in the pregeniculate (PrG) and subgeniculate (SubG), which are structures which circumvent the LGN rostrally at its dorsomedial border (Figure ; refer to Figure a,b for injection sites). The architectonic subdivision of the PrG and SubG could be determined with CB immunolabeling (Cavalcante et al, ; Lima et al, ) (Figure b). CB labeling showed two distinct areas in the marmoset, an area with dense neuropil immunoreactivity dorsally (PrG) with few CB+ cells, and an area lateral to PrG with more diffuse neuropil label but many darkly stained soma (SubG; Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…This result is further evidence for the segregation of the SC and PIm visual circuitry. While not much is known about the primate PrG, the neurochemical characteristics of its neurons and its bilateral retinal inputs (Hannibal et al, ) suggest it is the analog of the rodent ventral geniculate nucleus and intrageniculate leaflet, which are associated with circadian rhythm regulation (Lima et al, ). The functional implications of the connections shown here are not clear, and future research, for example, identifying the neurochemical properties of the PIm and SC projecting neurons is needed.…”

Section: Discussionmentioning

confidence: 99%

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Unravelling the subcortical and retinal circuitry of the primate inferior pulvinar

Kwan

Mundinano

Souza

et al. 2018

J of Comparative Neurology

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The primate visual brain possesses a myriad of pathways, whereby visual information originating at the retina is transmitted to multiple subcortical areas in parallel, before being relayed onto the visual cortex. The dominant retinogeniculostriate pathway has been an area of extensive study, and Vivien Casagrande's work in examining the once overlooked koniocellular pathway of the lateral geniculate nucleus has generated interest in how alternate subcortical pathways can contribute to visual perception. Another subcortical visual relay center is the inferior pulvinar (PI), which has four subdivisions and numerous connections with other subcortical and cortical areas and is directly recipient of retinal afferents. The complexity of subcortical connections associated with the PI subdivisions has led to differing results from various groups. A particular challenge in determining the exact connectivity pattern has been in accurately targeting the subdivisions of the PI with neural tracers. Therefore, in the present study, we used a magnetic resonance imaging (MRI)-guided stereotaxic injection system to inject bidirectional tracers in the separate subdivisions of the PI, the superior layers of the superior colliculus, the retina, and the lateral geniculate nucleus. Our results have determined for the first time that the medial inferior pulvinar (PIm) is innervated by widefield retinal ganglion cells (RGCs), and this pathway is not a collateral branch of the geniculate and collicular projecting RGCs. Furthermore, our tracing data shows no evidence of collicular terminations in the PIm, which are confined to the centromedial and posterior PI.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unravelling the subcortical and retinal circuitry of the primate inferior pulvinar

Kwan

Mundinano

Souza

et al. 2018

J of Comparative Neurology

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“…A similar IR pattern was reported in the golden hamster ( Morin et al, 1992 ). In addition, GAD-IR neurons were visualized in the rat ( Moore and Speh, 1993 ; Moore and Card, 1994 ), ground squirrel ( Agarwala et al, 1992 ) and primate PGN, such as the marmoset ( Lima et al, 2012 ), Rhesus monkey and Cynomolgus monkey ( Livingston and Mustari, 2000 ). In the flat-faced fruit-eating bat, neither SCN or IGL have shown GAD-IR cells, despite a plexus of GAD-IR fibers have been revealed throughout rostrocaudal length.…”

Section: Discussionmentioning

confidence: 99%

The Suprachiasmatic Nucleus and the Intergeniculate Leaflet of the Flat-Faced Fruit-Eating Bat (Artibeus planirostris): Retinal Projections and Neurochemical Anatomy

et al. 2018

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In mammals, the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) are the main components of the circadian timing system. The SCN, classically known as the master circadian clock, generates rhythms and synchronizes them to environmental cues. The IGL is a key structure that modulates SCN activity. Strategies on the use of time by animals can provide important clues about how some species are adapted to competitive process in nature. Few studies have provided information about temporal niche in bats with special attention on the neural substrate underlies circadian rhythms. The aim of this study was to investigate these circadian centers with respect to their cytoarchitecture, chemical content and retinal projections in the flat-faced fruit-eating bat (Artibeus planirostris), a chiropteran endemic to South America. Unlike other species of phyllostomid bats, the flat-faced fruit-eating bat’s peak of activity occurs 5 h after sunset. This raises several questions about the structure and function of the SCN and IGL in this species. We carried out a mapping of the retinal projections and cytoarchitectural study of the nuclei using qualitative and quantitative approaches. Based on relative optical density findings, the SCN and IGL of the flat-faced fruit-eating bat receive bilaterally symmetric retinal innervation. The SCN contains vasopressin (VP) and vasoactive intestinal polypeptide (VIP) neurons with neuropeptide Y (NPY), serotonin (5-HT) and glutamic acid decarboxylase (GAD) immunopositive fibers/terminals and is marked by intense glial fibrillary acidic protein (GFAP) immunoreactivity. The IGL contains NPY perikarya as well as GAD and 5-HT immunopositive terminals and is characterized by dense GFAP immunostaining. In addition, stereological tools were combined with Nissl stained sections to estimate the volumes of the circadian centers. Taken together, the present results in the flat-faced fruit-eating bat reveal some differences compared to other bat species which might explain the divergence in the hourly activity among bats in order to reduce the competitive potential and resource partitioning in nature.

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“…Anterograde labeling techniques show that there are substantial projections from the retina to non-geniculate thalamic areas including the pulvinar complex (Warner et al, 2010), pregeniculate nucleus (potentially homologous to the intrageniculate leaflet and ventral geniculate nucleus of rodents: Lima et al, 2012), and smaller projections to the midline and dorsomedial thalamic nuclei (Cavalcante et al, 2005; de Sousa et al, 2013). There are also projections from the retina to the accessory optic system, including the medial terminal nucleus (Weber and Giolli, 1986).…”

Section: The Marmoset Eyementioning

confidence: 99%

A simpler primate brain: the visual system of the marmoset monkey

Solomon

Rosa

2014

Front. Neural Circuits.

157

135

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Humans are diurnal primates with high visual acuity at the center of gaze. Although primates share many similarities in the organization of their visual centers with other mammals, and even other species of vertebrates, their visual pathways also show unique features, particularly with respect to the organization of the cerebral cortex. Therefore, in order to understand some aspects of human visual function, we need to study non-human primate brains. Which species is the most appropriate model? Macaque monkeys, the most widely used non-human primates, are not an optimal choice in many practical respects. For example, much of the macaque cerebral cortex is buried within sulci, and is therefore inaccessible to many imaging techniques, and the postnatal development and lifespan of macaques are prohibitively long for many studies of brain maturation, plasticity, and aging. In these and several other respects the marmoset, a small New World monkey, represents a more appropriate choice. Here we review the visual pathways of the marmoset, highlighting recent work that brings these advantages into focus, and identify where additional work needs to be done to link marmoset brain organization to that of macaques and humans. We will argue that the marmoset monkey provides a good subject for studies of a complex visual system, which will likely allow an important bridge linking experiments in animal models to humans.

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Retinal projections and neurochemical characterization of the pregeniculate nucleus of the common marmoset (Callithrix jacchus)

Cited by 16 publications

References 49 publications

Unravelling the subcortical and retinal circuitry of the primate inferior pulvinar

Unravelling the subcortical and retinal circuitry of the primate inferior pulvinar

The Suprachiasmatic Nucleus and the Intergeniculate Leaflet of the Flat-Faced Fruit-Eating Bat (Artibeus planirostris): Retinal Projections and Neurochemical Anatomy

A simpler primate brain: the visual system of the marmoset monkey

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