Retinal side-effects of sildenafil

Vobig, Michael A.

doi:10.1016/s0140-6736(98)05473-7

Cited by 98 publications

(38 citation statements)

References 4 publications

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“…Pilot studies testing the ability of the PDE5 inhibitor sildenafil to lower IOP were not successful. A single oral dose of 50–100 mg sildenafil failed to impact IOP in POAG patients (Grunwald et al, 2001) and healthy volunteers (Vobig et al, 1999; Sponsel et al, 2000), but did increase blood flow in both healthy subjects (Sponsel et al, 2000; Foresta et al, 2008) and patients with systemic vascular dysfunction (Koksal et al, 2005). Also chronic treatment with sildenafil (twice per week for 3 months) failed to impact IOP (Dundar et al, 2006).…”

Section: The No-cgmp Pathway As a Therapeutic Target For Poagmentioning

confidence: 99%

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

Buys

Potter

Pasquale

et al. 2014

Front. Mol. Neurosci.

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Glaucoma is a progressive optic neuropathy characterized by visual field defects that ultimately lead to irreversible blindness (Alward, 2000; Anderson et al., 2006). By the year 2020, an estimated 80 million people will have glaucoma, 11 million of which will be bilaterally blind. Primary open-angle glaucoma (POAG) is the most common type of glaucoma. Elevated intraocular pressure (IOP) is currently the only risk factor amenable to treatment. How IOP is regulated and can be modulated remains a topic of active investigation. Available therapies, mostly geared toward lowering IOP, offer incomplete protection, and POAG often goes undetected until irreparable damage has been done, highlighting the need for novel therapeutic approaches, drug targets, and biomarkers (Heijl et al., 2002; Quigley, 2011). In this review, the role of soluble (nitric oxide (NO)-activated) and membrane-bound, natriuretic peptide (NP)-activated guanylate cyclases that generate the secondary signaling molecule cyclic guanosine monophosphate (cGMP) in the regulation of IOP and in the pathophysiology of POAG will be discussed.

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Section: The No-cgmp Pathway As a Therapeutic Target For Poagmentioning

confidence: 99%

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

Buys

Potter

Pasquale

et al. 2014

Front. Mol. Neurosci.

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“…Thus, sildena®l increases the NO-stimulated cyclic GMP concentration in men with erectile dysfunction and thereby improves erection. Side eects are related to the mode of action of sildena®l and include headache and ushing, gastrointestinal side eects [4,14,18,26], and visual disturbances caused by retinal eects, which occur in about 5% of patients [29,30]. Up to now, there have been no reports as to the possible cognitive eects of sildena®l, although the presence of PDE-5 in brain tissue has been veri®ed [13,16].…”

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confidence: 99%

Central effects of sildenafil (Viagra) on auditory selective attention and verbal recognition memory in humans: a study with event-related brain potentials

et al. 2001

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The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a spatial auditory attention and a visual word recognition task. While behavioral patterns did not reveal any overt effects of sildenafil, auditory ERPs were indicative of an enhanced ability to focus attention (amplitude enhancement of Nd-effect) and to select relevant target stimuli in the sildenafil condition (P3 component). In the memory task, CNS-effects of sildenafil were evident in a reduction of a negativity in the 150-250 ms range. No overt effects on behavior were observed. Nevertheless, the data reveal CNS-effects of sildenafil necessitating further studies.

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“…However, they asserted that the heterozygous PDE6γ subunit knockout mutation probably leads to a decrease in the amount of functional PDE6, creating an enhanced susceptibility to the inhibitory effects of sildenafil. In contrast, Vobig et al (15) reported significant reductions in the a-, and b-wave amplitudes 1 hr after administering sildenafil, and these effects recovered to normal levels after 6 hr. The amplitude reduction correlated well with the slidenafil plasma concentration, which showed a peak 1 hr after administering the drug.…”

Section: Discussionmentioning

confidence: 90%

Effect of DA-8159, a Selective Phosphodiesterase Type 5 Inhibitor, on Electroretinogram and Retinal Histology in Rabbits

et al. 2004

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DA-8159, a selective inhibitor of phosphodiesterase type 5, was developed as a new drug for erectile dysfunction. The effect of DA-8159 on the electroretinogram (ERG) and the retinal histopathology were evaluated in rabbits. The ERG was performed prior to, and 1 and 5 hr after DA-8159 (5 to 30 mg/kg) administration. The plasma concentration of DA-8159 was determined at each time point, and retinal microscopic examination was also performed. There was no statistically significant ERG change at any dose or at any time. Though the 30 Hz flicker showed a prolongation of the implicit time at 5 hr after the administration of either DA-8159 15 mg or 30 mg/kg (p<0.05), but concurrent amplitude decreases were not statistically significant. At a dose of 5 mg/kg, no test drug was detected in the blood after either 1 or 5 hr. At either 15 mg/kg or 30 mg/kg, there was a dose-dependent increase in the blood concentration after 1 hr of drug administration, which decreased with time. In light and electron microscopic examinations of the retina, there was no remarkable change at any dose. These results suggest DA-8159 has a low risk potential to the retina, but further evaluation on the visual functions in human is needed.

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Retinal side-effects of sildenafil

Cited by 98 publications

References 4 publications

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

Central effects of sildenafil (Viagra) on auditory selective attention and verbal recognition memory in humans: a study with event-related brain potentials

Effect of DA-8159, a Selective Phosphodiesterase Type 5 Inhibitor, on Electroretinogram and Retinal Histology in Rabbits

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