Retinal Thickness Analysis for Quantitative Assessment of Diabetic Macular Edema

Shahidi, Mahnaz; Ogura, Yuichiro; Blair, Norman P.; Rusin, Mark M.; Zeimer, Ran

doi:10.1001/archopht.1991.01080080075032

Cited by 132 publications

(66 citation statements)

References 11 publications

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“…The RTA was designed to detect macular thickness and offers excellent imaging characteristics (17,18,36). It is similar to another instrument, the optical coherence tomograph, and allows an even more sensitive detection of macular edema than stereoscopic fundus examination by a retina specialist (20,26).…”

Section: Retinal Thickness Mapsmentioning

confidence: 99%

“…The retinal thickness analyzer (RTA; Talia Technology, Neve-Ilan, Israel) is an optical imaging instrument that allows objective, accurate, and quantitative measurement of retinal thickness. It has been shown to be more sensitive than slit-lamp biomicroscopy and photography in detecting localized areas of retinal thickness and may even demonstrate retinal thickening before retinopathy is diagnosed in diabetic patients (17)(18)(19). For this purpose, the RTA has been reported to be at least equivalent to another optical imaging instrument allowing macular thickness measurements, the Optical Coherence Tomograph (ZeissHumphrey Instruments, San Leandro, CA) (20).…”

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confidence: 99%

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Tele-Screening for Diabetic Retinopathy With the Retinal Thickness Analyzer

et al. 2003

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OBJECTIVE -To compare the effectiveness of tele-screening using a novel enhanced retinal thickness analyzer (RTA) with onsite routine ophthalmologic examination for diabetic retinopathy. RESEARCH DESIGN AND METHODS-A consecutive series of 31 eyes from diabetic patients were included. All underwent ophthalmologic examination, including stereoscopic dilated funduscopy and scanning with the RTA. The RTA reports consisted of a wide-angle, red-free fundus photograph and a macular-region retinal thickness map. Reports were graded by three independent graders in a masked manner. The diagnoses of proliferative retinopathy, macular edema, and treatment decisions made by the RTA graders and the clinical examiner were compared.RESULTS -On clinical examination 5 of 31 eyes were diagnosed with proliferative diabetic retinopathy (PDR). All five were referred for treatment by two graders and four eyes by one grader. All eyes with PDR and 12 of the 26 eyes with nonproliferative diabetic retinopathy showed severe macular edema. Seven of the 12 eyes with macular edema were clinically eligible for focal laser treatment, and all of them were detected by all RTA graders. Macular thickening was detected in eight eyes by RTA where no treatment was necessary, as judged by clinical examination. Thus, sensitivity was 93% (mean) for detecting PDR and 100% for detecting macular edema, with a specificity of 58 -96% depending on the grader. The RTA did not allow valid assessment due to poor image quality in only one case.CONCLUSIONS -Screening for diabetic retinopathy with a combination of wide-angle fundus photography and macular thickness mapping by an objective method, such as optical coherence tomography or the RTA, offers the prerequisites for establishing a successful telescreening program. Diabetes Care 26:2890 -2897, 2003D iabetic retinopathy is a leading cause of visual impairment and blindness in developed countries. Macular edema is the major cause of vision loss in diabetic patients, while proliferative retinopathy is another common cause (1). An annual clinical examination of dilated pupils by an ophthalmologist is the current gold standard of care for reducing diabetes-related ocular complications in patients with no or mild diabetic retinopathy (2). In the Early Treatment Diabetic Retinopathy Study (ETDRS), this led to a reduction of moderate visual loss by 50% (3).In many countries, an effective population-based screening cannot be offered by ophthalmologists and is performed by optometrists or general practitioners (4). One possible way to increase the number of ophthalmologically monitored diabetic patients is teleophthalmologic examination by a specialist (5-9). The gold standard of photographic documentation consists of seven stereoscopic fundus photographs, as defined by the ETDRS, requiring expensive equipment and a skilled photographer (10). Consequently, a number of alternative photographic methods have been evaluated for this purpose and are potentially able to identify patients requiring laser treatment (11).Recentl...

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Section: Retinal Thickness Mapsmentioning

confidence: 99%

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confidence: 99%

Tele-Screening for Diabetic Retinopathy With the Retinal Thickness Analyzer

et al. 2003

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“…Stereoscopic examination of the fundus is the standard method, as defined by the ETDRS, for evaluating macular thickening. However, it is subjective and seems to be insensitive for small changes in retinal thickness Shahidi et al, 1991). The particular value of OCT is the possibility for objective, reliable and repeatable retinal thickness measurements.…”

Section: Oct Findings In Dme 31 Retinal Thicknessmentioning

confidence: 99%

“…Fluorescein angiography is a complementary method for further detecting vascular leakage. However, these methods are subjective and seem to be insensitive for small changes in retinal thickness Shahidi et al, 1991). In 1991 a revolutionary device was introduced in ophthalmology -optical coherence tomography (OCT) -and it dramatically improved the diagnosis of macular pathology (Huang et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography Findings in Diabetic Macular Edema

Koleva-Georgieva¹

2012

Diabetic Retinopathy

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“…4 Furthermore, a number of ocular conditions are evaluated through the use of OCT, 5 and it has become a key diagnostic tool in a number of retinal diseases. 6 Diagnostic decisions are often guided by quantitative measurements obtained via OCT. For example, visualization of macular edema is used as a diagnostic guide for age-related macular degeneration patients, 7 while parameters such as increased macular thickness are often used to assess central vision deterioration. 8 Glaucoma diagnosis has been significantly enhanced through nerve fiber layer (NFL) thickness measurements 1,9 obtained by OCT, and by quantitative monitoring of the cup-to-disc ratio.…”

Section: Introductionmentioning

confidence: 99%

Retina-simulating phantom for optical coherence tomography

et al. 2013

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Abstract. Optical coherence tomography (OCT) is a rapidly growing imaging modality, particularly in the field of ophthalmology. Accurate early diagnosis of diseases requires consistent and validated imaging performance. In contrast to more well-established medical imaging modalities, no standardized test methods currently exist for OCT quality assurance. We developed a retinal phantom which mimics the thickness and near-infrared optical properties of each anatomical retinal layer as well as the surface topography of the foveal pit. The fabrication process involves layer-by-layer spin coating of nanoparticle-embedded silicone films followed by laser micro-etching to modify the surface topography. The thickness of each layer and dimensions of the foveal pit are measured with high precision. The phantom is embedded into a commercially available, water-filled model eye to simulate ocular dispersion and emmetropic refraction, and for ease of use with clinical OCT systems. The phantom was imaged with research and clinical OCT systems to assess image quality and software accuracy. Our results indicate that this phantom may serve as a useful tool to evaluate and standardize OCT performance. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Retinal Thickness Analysis for Quantitative Assessment of Diabetic Macular Edema

Cited by 132 publications

References 11 publications

Tele-Screening for Diabetic Retinopathy With the Retinal Thickness Analyzer

Tele-Screening for Diabetic Retinopathy With the Retinal Thickness Analyzer

Optical Coherence Tomography Findings in Diabetic Macular Edema

Retina-simulating phantom for optical coherence tomography

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