Retinal Toxicity of Intravitreal Cefoperazone

O’Hara, Mary; Bode, Donald; Kincaid, Marilyn C.; Perkins, Michael S.

doi:10.1089/jop.1986.2.177

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Focal areas of retinal necrosis were present in eyes injected with more than 10 tzg of itraconazole. The focal areas of retinal necrosis were discrete and located near the site where the eye was injected, and may have been a sequela of the injection technique [14,12]. Diffuse retinal changes were not present in any eye (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Ocular toxicity of experimental intravitreal itraconazole

et al. 1991

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We investigated itraconazole, a new triazole antifungal agent that poorly penetrates ocular tissues after oral administration. We injected itraconazole in doses from 10 to 100 micrograms dissolved in 100% dimethyl sulfoxide into the eyes of New Zealand rabbits. Ocular toxicity studies performed five weeks after administration showed no substantial retinal or histopathologic changes in eyes injected with either 100% dimethyl sulfoxide or 10 micrograms of itraconazole. Higher doses caused focal areas of retinal necrosis. Our results indicated that intravitreal doses of 10 micrograms or less of itraconazole may be beneficial in the treatment of fungal endophthalmitis.

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Section: Resultsmentioning

confidence: 99%

Ocular toxicity of experimental intravitreal itraconazole

et al. 1991

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Retinal Function Assessed by ERG Before and After Induction of Ocular Aspergillosis and Treatment by the Anti-fungal, Micafungin, in Rabbits

et al. 2005

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This study was conducted to evaluate the effectiveness of a new antifungal drug, micafungin, and standard antifungal drugs against endophthalmitis induced in a rabbit by intravitreal injection of Aspergillus fumigatus, an important fungal pathogen. Effectiveness was evaluated by the preservation of b-wave amplitude at 72 h after injection of the fungus relative to the b-wave amplitude at baseline before any intravitreal injections. A 0.06 ml inoculum of 10(6) conidia of A. fumigatus was injected into the vitreous of the right eye of all rabbits; and, 12 h later, a 0.06 ml solution containing one of 3 antifungal drugs or saline was injected into the vitreous of both eyes. All three antifungal drugs produced significant b-wave preservation at 72 h in infected eyes compared to that in infected eyes receiving saline injections. There was no statistically significant difference between the effects of micafungin and amphotericin B in the right eyes with fungal endophthalmitis, and both produced significantly more preservation of b-wave amplitude than voriconazole. Amphotericin B, but neither micafungin nor voriconazole produced significant reduction of the b-wave amplitude in the left eyes.

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Retinal Toxicity of Intravitreal Cefoperazone

Cited by 2 publications

References 15 publications

Ocular toxicity of experimental intravitreal itraconazole

Ocular toxicity of experimental intravitreal itraconazole

Retinal Function Assessed by ERG Before and After Induction of Ocular Aspergillosis and Treatment by the Anti-fungal, Micafungin, in Rabbits

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