Retinal vascular changes in rats with inherited hypercholesterolemia – Corrosion cast demonstration

Yamakawa, Kenji; Bhutto, Imran Ahmed; Lu, Zhongyang; Watanabe, Youji; Amemiya, Tsugio

doi:10.1076/ceyr.22.4.258.5501

Cited by 33 publications

(17 citation statements)

References 10 publications

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“…It was not reported whether these participants had DR. As we do not have metabolic data available for analysis, we cannot confirm these results in our population. However, one theory that may shed light on our findings proposes that impairment of retinal perfusion and retinal endothelial dysfunction may be associated with decreased tortuosity of the retinal vasculature [50,51,52]. …”

Section: Discussionmentioning

confidence: 99%

Retinal Vascular Calibre, Geometry and Progression of Diabetic Retinopathy in Type 2 Diabetes Mellitus

2012

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Purpose: To determine whether changes in retinal vascular calibre and geometry are associated with progression of diabetic retinopathy in type 2 diabetes (T2D). Procedures: The retinal vascular calibre and geometry of 30 subjects with more than 20 years of diagnosed T2D with no retinopathy (NR) were compared to 30 subjects that progressed to proliferative diabetic retinopathy (PDR). The images of PDR subjects included in this study were those obtained before the onset of retinopathy. The diameter of retinal arterioles (CRAE), retinal venules (CRVE), tortuosity of retinal vessels, junctional exponent deviation (JE_a) and fractal dimension (D_f) were measured using Singapore I Vessel Assessment (SIVA 3.0) software and compared using Mann-Whitney U test. Results: The median CRAE and the median CRVE were significantly wider in PDR subjects compared to NR subjects (p = 0.014 and 0.016), respectively. Curvature tortuosity of the retinal arteries and veins and D_f were significantly decreased in the PDR subjects compared to NR subjects (p = 0.015, 0.016 and 0.03, respectively). The JE_a was significantly increased in PDR subjects (p = 0.01). Conclusions: Retinal vessel calibre and geometry of the retinal vasculature may be important risk factors for the progression to PDR. More longitudinal prospective studies will be needed to further explore the findings of this study.

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Section: Discussionmentioning

confidence: 99%

Retinal Vascular Calibre, Geometry and Progression of Diabetic Retinopathy in Type 2 Diabetes Mellitus

2012

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“…Endothelial cells have a major role in the regulation of microvascular blood flow and angiogenesis. Increased angiogenesis and increased flow are associated with increased tortuosity in the retina, 29,30 and decreased tortuosity is predicted to impair oxygenation. 31 We, therefore, speculate that reduced microvascular tortuosity may be linked to endothelial dysfunction and a widespread impairment of perfusion or oxygenation in the microvasculature.…”

Section: Discussionmentioning

confidence: 99%

Abnormalities of Retinal Microvascular Structure and Risk of Mortality From Ischemic Heart Disease and Stroke

et al. 2006

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Abstract-Abnormalities of the retinal microcirculation are found in hypertension and diabetes and predict cardiovascular mortality. This study examined the relationship between abnormalities of the retinal microvasculature and death from ischemic heart disease (IHD) and stroke. A population-based, nested case-control study was undertaken within the Beaver Dam Eye Study. Subjects (43 to 74 years) who died of IHD (nϭ126) or stroke (nϭ28) over a 10-year period were age and gender matched with controls subjects (nϭ528; case:control matching, Ϸ1:4). Retinal photographs of cases and controls were digitized and analyzed using a computer-based technique. Increased risk of IHD death was associated with a suboptimal relationship of arteriolar diameters at bifurcation (Pϭ0.02 unadjusted) and decreased retinal arteriolar tortuosity (Pϭ0.011 unadjusted). These associations remained significant after adjustment for age, sex, past history of cardiovascular disease, and other known cardiovascular risk factors. Increased arteriolar length:diameter ratio, a measure of generalized arteriolar narrowing, was associated with increased stroke mortality (Pϭ0.02 unadjusted). This association was independent of age and gender but was attenuated by adjustment for systolic blood pressure (Pϭ0.15). Other quantitative measures of the retinal microvascular network (eg, venular tortuosity and arteriolar and venular bifurcation angle) were not associated with death from IHD or stroke. Retinal microvascular abnormalities are predictive of death from IHD and stroke. A detailed assessment of the retinal microvascular network from digitized photographs may be useful in the noninvasive assessment of target organ damage and cardiovascular risk.

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“…Few experimental studies examine the effects of hypercholesterolaemia on the posterior segment of the eye [154][155][156][157][158][159]. Hypercholesterolaemic rabbits constitute a useful model to delve into the repercussions of excess lipids at the ocular level.…”

Section: Choroidal Changes Induced By Hypercholesterolaemiamentioning

confidence: 99%

Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

Sebastián¹,

Corral²,

Montañana³

et al. 2012

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans

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Retinal vascular changes in rats with inherited hypercholesterolemia – Corrosion cast demonstration

Abstract: These findings indicate that the retinal capillary changes are probably related to hypercholesterolemia.

Cited by 33 publications

References 10 publications

Retinal Vascular Calibre, Geometry and Progression of Diabetic Retinopathy in Type 2 Diabetes Mellitus

Retinal Vascular Calibre, Geometry and Progression of Diabetic Retinopathy in Type 2 Diabetes Mellitus

Abnormalities of Retinal Microvascular Structure and Risk of Mortality From Ischemic Heart Disease and Stroke

Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

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