Retinal vascular density evaluation of migraine patients with and without aura and association with white matter hyperintensities

Ulusoy, Mahmut Oğuz; Horasanlı, Bahriye; Kal, Alı

doi:10.1007/s13760-019-01094-7

Cited by 34 publications

(53 citation statements)

References 31 publications

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“…There have been also reports to assess the use of OCT-A and its ability to detect vascular changes in the retina of patients with migraines with aura and without aura. 120,121 Chang et al described that patients with migraine with aura exhibited enlarged foveal avascular zone (FAZ), reduced parafoveal SCP blood flow and reduced RPC superiorly compared to those without aura and also compared to healthy controls. 120 The authors did not observe any changes in OCT-A of patients with migraine without aura and healthy controls.…”

Section: Migrainesmentioning

confidence: 99%

“…120 Ulusoy et al agreed with the findings of the above study about patients suffering with migraines with aura, but in their study, they also observed changes in the blood flow in the macular and optic nerve region in patients without aura as well. 121 The authors also tried to correlate these findings with white matter hyperintensities observed in the MRI brain of patients with migraines with and without aura. 121 The authors observed there was a statistically significant correlation of the OCT-A findings and the MRI findings only in the migraine with aura group.…”

Section: Migrainesmentioning

confidence: 99%

“…121 The authors also tried to correlate these findings with white matter hyperintensities observed in the MRI brain of patients with migraines with and without aura. 121 The authors observed there was a statistically significant correlation of the OCT-A findings and the MRI findings only in the migraine with aura group. 121 A study published in April 2020 looked at patients with migraines without aura.…”

Section: Migrainesmentioning

confidence: 99%

See 2 more Smart Citations

<p>Optical Coherence Tomography Angiography in Neurodegenerative Diseases: A Review</p>

Tsokolas

Tsaousis

Diakonis

et al. 2020

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Background: Optical coherence tomography angiography (OCT-A) has emerged as a novel, fast, safe and non-invasive imaging technique of analyzing the retinal and choroidal microvasculature in vivo. OCT-A captures multiple sequential B-scans performed repeatedly over a specific retinal area at high speed, thus enabling the composition of a vascular map with areas of contrast change (high flow zones) and areas of steady contrast (slow or no flow zones). It therefore provides unique insight into the exact retinal or choroidal layer and location at which abnormal blood flow develops. OCTA has evolved into a useful tool for understanding a number of retinal pathologies such as diabetic retinopathy, age-related macular degeneration, central serous chorioretinopathy, vascular occlusions, macular telangiectasia and choroidal neovascular membranes of other causes. OCT-A technology is also increasingly being used in the evaluation of optic disc perfusion and has been suggested as a valuable tool in the early detection of glaucomatous damage and monitoring progression. Objective: To review the existing literature on the applications of optical coherence tomography angiography in neurodegenerative diseases. Summary: A meticulous literature was performed until the present day. Google Scholar, PubMed, Mendeley search engines were used for this purpose. We used 123 published manuscripts as our references. OCT-A has been utilized so far to describe abnormalities in multiple sclerosis (MS), Alzheimer's disease, arteritic and non-arteritic optic neuropathy (AION and NAION), Leber's hereditary optic neuropathy (LHON) papilloedema, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), Wolfram syndrome, migraines, lesions of the visual pathway and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). It appears that OCT-A findings correlate quite well with the severity of the aforementioned diseases. However, OCT-A has its own limitations, namely its lack of wide-field view of the peripheral retina and the inaccurate interpretation due to motion artifacts in uncooperative groups of patients (e.g. children). Larger prospective longitudinal studies will need to be conducted in order to eliminate the aforementioned limitations.

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Section: Migrainesmentioning

confidence: 99%

Section: Migrainesmentioning

confidence: 99%

Section: Migrainesmentioning

confidence: 99%

See 1 more Smart Citation

<p>Optical Coherence Tomography Angiography in Neurodegenerative Diseases: A Review</p>

Tsokolas

Tsaousis

Diakonis

et al. 2020

View full text Add to dashboard Cite

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“…However, those findings were heterogeneous, and all studies were hampered by the absence of brain and orbit MRI to exclude optic neuropathy or CSVD (Table 1). Indeed, pRNFL thinning has been associated with optic neuropathies [25], and CSVD-surrogate WMHs in the general population [26,27] and HIV-infected children [28].…”

Section: Introductionmentioning

confidence: 99%

Absence of peripapillary retinal nerve-fiber–layer thinning in combined antiretroviral therapy-treated, well-sustained aviremic persons living with HIV

et al. 2020

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To compare peripapillary retinal nerve-fiber-layer (pRNFL) thickness, total retina macular volume, and ganglion-cell-layer (GCL) macular volume and thickness between persons living with HIV (PLHIVs) with well-controlled infections and good immune recovery, and sexand age-matched HIV-uninfected controls (HUCs). Methods This prospective cross-sectional study (www.clinicaltrials.gov identifier: NCT02003989) included 56 PLHIVs, infected for �10 [median 20.2] years and with sustained plasma HIVload suppression on combined antiretroviral therapy (cART) for �5 years, and 56 matched HUCs. Participants underwent spectral-domain optical coherence tomography (SD-OCT) with thorough ophthalmological examinations and brain magnetic resonance imaging (MRI). Their overall and quadrant pRNFL thicknesses, total macular volumes, and GCL macular volumes and thicknesses were compared. Cerebral small-vessel diseases (CSVD) complied with STRIVE criteria. Results Median [interquartile range, IQR] ages of PLHIVs and HUCs, respectively, were 52 [46-60] and 52 [44-60] years. Median [IQR] PLHIVs' nadir CD4+ T-cell count and current CD4/CD8 T-cell ratio were 249/μL [158-350] and 0.

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“…As mentioned above, Acer et al [20] reported that the ocular pulse amplitude did not significantly differ between the migraine patients without aura and control cases. Very recently, Ulusoy et al [26] determined that on macular OCTA, the superficial and deeper retinal foveal VDs were significantly lesser in the migraine patients with and without aura compared with the control cases. Moreover, the authors noted that the vascular alterations were more common with an enlarged FAZ size in migraine cases with aura, in which WMHs were detected.…”

Section: Discussionmentioning

confidence: 99%

Altered Macular Vasculature in Migraine Patients without Aura: Is It Associated with Ocular Vasculature and White Matter Hyperintensities?

Taşlı

Ersoy

2020

Journal of Ophthalmology

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Aim. We aimed to determine the alterations in macular and optic nerve vasculature in patients with migraine without aura using optical coherence tomography-angiography (OCTA). We also aimed to determine whether there were clinical differences and alterations in ocular structures in migraine cases with white matter hyperintensities (WMH) using magnetic resonance imaging (MRI). Materials and Methods. The study group comprised patients with migraine without aura and age- and sex-matched healthy controls. Detailed histories of the patients with migraine were recorded including the disease duration, number of attacks in the last month, and attack durations. Visual evoked potentials (VEP) were recorded in all migraine patients. The migraine disability assessment (MIDAS) questionnaire was administered to all patients. The patients were divided into two groups as migraine with WMHs and migraine without WMHs. All subjects underwent a complete neurological and ophthalmological examination. Only the right eyes of the patients were included in the study. Retinal imaging was performed using OCT and OCTA. Results. A total of 66 migraine patients (29 with WMH and 37 without WMH) and 43 healthy controls were included in this study. Among the migraine patients, disease duration, attack frequency in the last month, attack durations, and the visual analogue scale (VAS), MIDAS, and VEP scores were all similar between those with and without WMHs. There was no significant difference between the groups regarding the ganglion cell complex, foveal, and retinal nerve fiber layer thicknesses. The superficial or deep vascular perfusion densities of the optic disc were also similar between the groups. The foveal avascular zone (FAZ) was significantly larger (P=0.034), and both superficial and deep macular vascular densities were significantly lower in the migraine groups compared with the healthy controls (P=0.001). There was no significant difference concerning the FAZ size or vascular densities between the migraine groups with and without WMHs. In the correlation analysis performed between the migraine patients, the FAZ size was correlated with age and VAS and MIDAS scores while both superficial and deep macular vascular densities were negatively correlated with age and VAS and MIDAS scores. Conclusion. We suggest that for not only migraine with aura but also migraine without aura, neurovascular structures play an important role in pathogenesis, and novel studies are warranted to elucidate the alterations in these and determine the significance of WMHs in these patient groups.

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Retinal vascular density evaluation of migraine patients with and without aura and association with white matter hyperintensities

Cited by 34 publications

References 31 publications

<p>Optical Coherence Tomography Angiography in Neurodegenerative Diseases: A Review</p>

<p>Optical Coherence Tomography Angiography in Neurodegenerative Diseases: A Review</p>

Absence of peripapillary retinal nerve-fiber–layer thinning in combined antiretroviral therapy-treated, well-sustained aviremic persons living with HIV

Altered Macular Vasculature in Migraine Patients without Aura: Is It Associated with Ocular Vasculature and White Matter Hyperintensities?

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