Retinal Vascular Occlusion Syndromes

Haymore, Jonathan; Mejico, Luis J.

doi:10.1097/iio.0b013e3181a8db88

Cited by 33 publications

(21 citation statements)

References 103 publications

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“…A notable finding of the current study was that patients with CRAO had a higher incidence of ACS (9.55%) than patients with BRAO (4.14%), despite nearly identical pathophysiologies 17. In addition, the HR for ACS in the patients with CRAO was 3.57 times higher than that of controls, even after adjustment for age, sex and selected comorbid disorders.…”

Section: Discussionmentioning

confidence: 42%

“…Over the last decade, multiple large population-based studies have reported significant associations between retinal microvascular changes, such as retinal arteriolar narrowing, and incident coronary disease or cardiovascular death 24–26. The direct role in the pathogenesis of RAO is impaired inner retinal blood supply, which is associated with arteriolar emboli and microvascular change of retinal arterioles 17. In addition, retinal arteriolar narrowing and arteriovenous nicking have been observed in patients with RAO 2 27…”

Section: Discussionmentioning

confidence: 99%

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The risk of acute coronary syndrome after retinal artery occlusion: a population-based cohort study

et al. 2014

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Section: Discussionmentioning

confidence: 42%

Section: Discussionmentioning

confidence: 99%

The risk of acute coronary syndrome after retinal artery occlusion: a population-based cohort study

et al. 2014

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“…Retinal vein occlusion (RVO) and retinal artery occlusion (RAO) may lead to visual loss [1][2][3][4]. Inherited hypercoagulability has attracted an increased interest as a cause of RAO and RVO [5,6].…”

Section: Introductionmentioning

confidence: 99%

Venous thromboembolism does not share familial susceptibility with retinal vascular occlusion or glaucoma: a nationwide family study

Zöller

Sundquist

et al. 2016

J Thromb Thrombolysis

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Inherited hypercoagulable states (i.e. thrombophilia) have been suggested to be involved in retinal vascular occlusion but results are divergent. Vascular micronutrition and ischemia have been hypothesised to be involved in the pathogenesis of glaucoma. This nationwide study determines the importance of family history of venous thromboembolism (VTE) as a risk factor for retinal vein occlusion (RVO), retinal artery occlusion (RAO), primary open angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). A total of 6,007,042 Swedish individuals were studied. Data from the Swedish Multigeneration Register for subjects aged 0-78 years old for the period 1997-2010 were linked to the Swedish Hospital Discharge Register and the Hospital Outpatient Register. Main exposure measure was family history of VTE in first-degree relatives (parents and/or siblings). Main outcomes were hazard ratios (HRs) for RVO, RAO, POAG, and PACG. During follow-up 9036 individuals developed RVO, 2137 individuals developed RAO, 29,176 individuals developed POAG and 1498 individuals developed PACG. There was no association between family history of VTE and risk of RVO (HR = 1.04, 95 % CI 0.98-1.10), RAO (HR = 1.00, 95 % CI 0.89-1.13), POAG (HR = 0.96, 95 % CI 0.93-0.99), and PACG (HR = 0.92, 95 % CI 0.80-1.06) in the crude age and sex adjusted model. The results were similar in the fully adjusted model: RVO (HR = 1.04, 95 % CI 0.99-1.11), RAO (HR = 1.01, 95 % CI 0.89-1.13), POAG (HR = 0.97, 95 % CI 0.94-1.00), and PACG (HR = 0.91, 95 % CI 0.79-1.05). Family history of VTE is not a risk factor for RVO, RAO, POAG and PACG. Thus, it is unlikely that strong and common genetic variants associated with VTE are of importance for these disorders.

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“…In nearly all cases, the artery lies anterior to the vein, making the vein vulnerable to compression by the artery, resulting in turbulent flow, which in turn leads to a predisposition toward endothelial damage and thrombus formation [10,11]. This process is exacerbated in the presence of arteriosclerosis [9,10,12,17]. Turbulent flow at arteriovenous crossing sites has been demonstrated by fluorescein angiography [5].…”

Section: Pathophysiologymentioning

confidence: 99%

“…The central retinal vein may be compressed by the central retinal artery since they share a common fibrous sleeve [17]. Degenerative or inflammatory disease of the central retinal vein wall, as well as hemodynamic factors such as hypotension and blood dyscrasia, may also play a role [17,18,19,20].…”

Section: Pathophysiologymentioning

confidence: 99%

Management of Retinal Vein Occlusion – Consensus Document

et al. 2011

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Retinal vein occlusion (RVO) can have severe consequences for the people affected by the disease, including visual loss with costly social repercussions. Currently, there is no European consensus with regard to the management of RVO. Following a careful review of the medical literature as well as the data from several clinical trials, a collaborative group of retina specialists put forth practical recommendations based on the best available scientific evidence for the clinical approach to RVO. Taking into consideration the recent advances in diagnostic tools and management options, the present document aims to provide the European ophthalmologists with guidelines for clinical practice to the benefit of their patients.

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Retinal Vascular Occlusion Syndromes

Cited by 33 publications

References 103 publications

The risk of acute coronary syndrome after retinal artery occlusion: a population-based cohort study

The risk of acute coronary syndrome after retinal artery occlusion: a population-based cohort study

Venous thromboembolism does not share familial susceptibility with retinal vascular occlusion or glaucoma: a nationwide family study

Management of Retinal Vein Occlusion – Consensus Document

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