Retinal Vasculitis Imaging by Adaptive Optics

Errera, Marie‐Hélène; Coisy, Solène; Fardeau, Christine; Sahel, José‐Alain; Kallel, Sofiene; Westcott, Mark; Bodaghi, Bahram; Pâques, M.

doi:10.1016/j.ophtha.2013.12.036

Cited by 31 publications

(23 citation statements)

References 6 publications

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“…71 Similarly, A/V nicking has been shown not to indicate physical compression by the arteriole, rather being produced by independent constriction of the vein. 49,72 In cases of retinal vasculitis, focal compression of vessels, opacification of perivascular tissue 73 and increased scatter arising from infiltrates (groups of extravasating leukocytes) in post-capillary venules have been demonstrated and tracked over time with AO imaging. 71 The microvasculature has also been studied in branch venous occlusions, where precise longitudinal tracking of vessels can be used to infer the ischaemic status of the retina.…”

Section: Other Focal Vascular Abnormalitiesmentioning

confidence: 99%

Adaptive optics imaging of the retinal microvasculature

Bedggood

Metha

2020

Clinical and Experimental Optometry

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The eye has long been recognised as the window to pathological processes occurring in the brain and other organs. By imaging the vasculature of the retina we have improved the scientific understanding and clinical best practice for a diverse range of conditions, ranging from diabetes, to stroke, to dementia. Mounting evidence suggests that damage to the smallest and most delicate vessels in the body, the capillaries, is the first sign in many vasculopathies. These are the most critical vessels involved in the exchange of metabolites with tissue. Accurate assessment of retinal capillary structure and function would therefore be of great benefit across a broad range of disciplines in medical science; however, their small size does not make this an easy task. This has led to the development of high‐resolution adaptive optics imaging methods to non‐invasively explore retinal microvascular networks in living human eyes. This review describes the present state of the art in the field, the scientific breakthroughs that have been made possible in the understanding of vessel structure and function in health and disease, and future directions for this emerging technology.

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Section: Other Focal Vascular Abnormalitiesmentioning

confidence: 99%

Adaptive optics imaging of the retinal microvasculature

Bedggood

Metha

2020

Clinical and Experimental Optometry

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“…Analysis of photoreceptor pointing on off-axis images are of interest in macular diseases, in which the visualization of the cone mosaic can be dramatically modified by multiangle observation (Miloudi et al 2015). In uveitis patients, we observed that paravascular inflammation (perivenous sheathing) may be more easily detected by AO than by other means (Errera et al 2014), providing us with a tool for mapping the extent of perivenous sheathing in cases of uveitis.…”

Section: Adaptive Optics For Retinal Imagingmentioning

confidence: 94%

Vision science and adaptive optics, the state of the field

et al. 2017

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Adaptive optics is a relatively new field, yet it is spreading rapidly and allows new questions to be asked about how the visual system is organized. The editors of this feature issue have posed a series of question to scientists involved in using adaptive optics in vision science. The questions are focused on three main areas. In the first we investigate the use of adaptive optics for psychophysical measurements of visual system function and for improving the optics of the eye. In the second, we look at the applications and impact of adaptive optics on retinal imaging and its promise for basic and applied research. In the third, we explore how adaptive optics is being used to improve our understanding of the neurophysiology of the visual system.

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“…Recently, we observed that AO may reveal paravascular cellular infiltrates in eyes with vascular inflammation [14], which are not otherwise detectable. This offers the opportunity of diagnosing vascular inflammation and also monitoring the therapy of such patients in a noninvasive way.…”

Section: Vascular Inflammationmentioning

confidence: 96%

Adaptive optics imaging of retinal microstructures: Image processing for medical applications

Pâques¹,

Rossant²,

Lermé³

et al. 2014

2014 International Workshop on Computational Intelligence for Multimedia Understanding (IWCIM)

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Adaptive optics (AO) fundus imaging is an optoelectronic technique allowing an improvement of an order of magnitude of lateral resolution of retinal images. Currently, its main applications in ophthalmology span from photoreceptor to retinal pigment epithelial cells and vessels, each of them being affected by specific diseases. Technological and image processing improvements are expanding the scope of its medical applications. Here we will review some of the current and envisioned applications of AO in clinical practice.Index Terms-adaptive optics retinal imaging, agerelated macular degeneration, photoreceptors, arterial hypertension.

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Retinal Vasculitis Imaging by Adaptive Optics

Cited by 31 publications

References 6 publications

Adaptive optics imaging of the retinal microvasculature

Adaptive optics imaging of the retinal microvasculature

Vision science and adaptive optics, the state of the field

Adaptive optics imaging of retinal microstructures: Image processing for medical applications

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