Retinal Vasculitis in Crohn's Disease

Duker, Jay S.; Brown, Gary C.; Brooks, Logan

doi:10.1016/s0002-9394(14)74326-0

Cited by 75 publications

(25 citation statements)

References 12 publications

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“…The microvasculature is thought to play a critical role in mediating inflammation. There is growing evidence of widespread inflammatory vasculitis with acti vation of the clotting cascade leading to microvascular damage and inflammation in the interstitial wall of blood vessels during the development of IBD (27)(28) . Angiogenesis has emerged as an additional vascular mechanism contributing to chronic inflammation in IBD (29)(30) .…”

Section: Discussionmentioning

confidence: 99%

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Önal¹,

Yüksel²,

Bayrakceken³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: Gazi University Ethics Committee. Number N o 53 -26/01/2015. ABSTRACTPurpose: Ocular inflammation is a frequent extraintestinal manifestation of inflammatory bowel disease (IBD) and may parallel disease activity. In this study, we evaluated the utility of a choroidal thickness measurement in assessing IBD activity. Methods: A total of 62 eyes of 31 patients with IBD [Crohn's disease (CD), n=10 and ulcerative colitis (UC), n=21] and 104 eyes of 52 healthy blood donors were included in this study. Choroidal thickness was measured using enhanced depth imaging optical coherence tomography. The Crohn's disease activity index (CDAI) and the modified Truelove Witts score were used to assess disease activity in CD and UC, respectively. Results: No significant differences in mean subfoveal, nasal 3000 µm, or temporal 3000 µm choroidal thickness measurements (P>0.05 for all) were observed between IBD patients and healthy controls. Age, smoking, CD site of involvement (ileal and ileocolonic involvement), CDAI, CD activity, and UC endoscopic activity index were all found to be significantly correlated with choroidal thickness by univariate analysis (P<0.05). Smoking (P<0.05) and the CD site of involvement (P<0.01) were the only independent parameters associated with increased choroidal thickness at all measurement locations. Conclusions: Choroidal thickness is not a useful marker of disease activity in patients with IBD but may be an indicator of ileal involvement in patients with CD.

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Section: Discussionmentioning

confidence: 99%

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Önal¹,

Yüksel²,

Bayrakceken³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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“…Ainda que a doença de Crohn e a retocolite ulcerativa sejam DII distintas, ambas podem cursar com trombose em qualquer leito vascular (11)(12) . Na doença de Crohn, as alterações vasculares retinianas como oclusão de ramo (13) , flebite (14) e OVCR (15) , têm sido relatadas em pacientes com DII em atividade, ou seja, com anormalidades de coagulação (aumento dos níveis de plaquetas, fator V e VIII, fibrinogênio e queda de antitrombina III) (12) . No caso clínico descrito, a paciente apresentava-se em fase de remissão da DII comprovado por exames laboratoriais.…”

Section: Discussionunclassified

“…A corticoterapia sistêmica tem sido usada para tratar episódios de tromboembolismo na doença de Crohn (13)(14) . Na OVCR pode haver remissão espontânea, mas como em 40% dos casos o prognós-tico é ruím, a corticoterapia (Meticorten ® ) foi indicada.…”

Section: Discussionunclassified

Oclusão venosa central de retina na remissão de doença de Crohn: relato de caso

Yamane¹,

Reis²,

Moraes³

2007

Arq. Bras. Oftalmol.

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“…Although systemic vasculitis can be a complication of infl ammatory bowel disease, which affects different parts of the body (skin, eyes, brain, and lung), retinal vasculitis in Crohn's disease is not very common [11]. A 26-year-old woman examined with biopsy is diagnosed with Crohn's disease.…”

Section: Retinal Vasculitis In Crohn's Diseasementioning

confidence: 99%

Crohn’s Disease Ocular Manifestations

Koev

2014

Acta Medica Bulgarica

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Summary Crohn’s disease is an inflammatory bowel disease which causes inflammation of the digestive tract. Crohn’s disease most frequently affects the ileum and the colon. In the active stage of the disease signs and symptoms may include diarrhea, abdominal pain and cramping, blood in the stools, reduced appetite and weight loss. In patients with severe Crohn’s disease the following signs and symptoms may be observed: fever, fatigue, arthritis, eye inflammation, oral ulcers, skin disorders, inflammation of the liver or bile ducts or delayed growth. Heredity and dysfunctions of the immune system are considered to cause the development of Crohn’s disease. About 10% of people with inflammatory bowel disease have also ocular problems. The most common ocular manifestations of Crohn’s disease are uveitis, iritis, episcleritis, keratopathy, keratoconjunctivitis and retinal vasculitis. Untreated uveitis may cause glaucoma and vision loss. Uveitis and iritis are four times more common in women than in men. In patients in the active stage of the disease, episcleritis also flares. Symptoms of episcleritis include inflammation, bright red spots on the sclera and localized pain. Keratoconjunctivitis in Crohn’s disease is caused by decreased tear production or increased tear film evaporation. Dry eyes can cause itching, burning or infection. Keratopathy usually causes no pain or vision loss, therefore in most cases no treatment is needed. In retinal vasculitis tortuosity of retinal veins, retinal edema at the posterior pole and intraretinal blood near blood vessels are observed. Intravenous fluorescein angiography shows intraretinal neovascularisation and haemorrhage in the posterior pole.

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Retinal Vasculitis in Crohn's Disease

Cited by 75 publications

References 12 publications

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Oclusão venosa central de retina na remissão de doença de Crohn: relato de caso

Crohn’s Disease Ocular Manifestations

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