Retinal vein occlusion during flare of multicentric Castleman&amp;#39;s disease

Kozák, Igor; Reid, Erin

doi:10.2147/opth.s47448

Cited by 6 publications

(3 citation statements)

References 11 publications

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“… 9 Less frequently reported ocular signs are retinal hemorrhage, subretinal fluid, macular edema, cotton wool spot, choroidal neovascularization, central retinal artery occlusion, and serous retinal detachment. 10 , 11 The ocular findings of bilateral optic disc swelling with macula edema seen as a coinfection with B. henselae neuroretinitis as highlighted in our case has not been presented in any previous review.…”

Section: Discussionmentioning

confidence: 65%

Bartonella henselae Neuroretinitis: A Rare Coinfection in POEMS Syndrome

Kahar¹,

Muhammed²,

Hitam³

et al. 2020

tjo

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Section: Discussionmentioning

confidence: 65%

Bartonella henselae Neuroretinitis: A Rare Coinfection in POEMS Syndrome

Kahar¹,

Muhammed²,

Hitam³

et al. 2020

tjo

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“…CD rarely leads to direct involvement of the orbit or ocular structures due to a lack of lymphoid tissue in the eye [10]. Several investigators have reported rare intraocular involvement [7][8][9][10][11][12]; however, the pathogenic mechanism of ocular involvement is not fully understood. We report a case of hypertensive choroidopathy in a patient with CD associated with malignant hypertension.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Multicentric Castleman Disease Presenting With Hypertensive Choroidopathy: A Case Report

Mimoto¹,

Hashida²,

Nishida³

2023

Cureus

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Castleman disease (CD) is a lymphoproliferative disorder and rarely affects ocular tissue. This study aimed to report a case of hypertensive choroidopathy in a patient with Castleman's disease associated with malignant hypertension. A 39-year-old man visited his local physician with fever, systemic edema, and multiple lymphadenopathies. An inguinal lymph node biopsy indicated CD. One month after the biopsy, the patient noted a blurring of vision. At the time of the initial examination at our hospital, his best-corrected visual acuity (BCVA) was 20/20 in both eyes but there were bilateral multiple Elschnig spots and sprinter hemorrhage at the fundus. Swept-source optical coherence tomography showed intra-retinal fluid, and serous retinal detachment (SRD). Fluorescein angiography revealed multiple punctate hyper fluorescences and indocyanine green angiography showed choroidopathy with increased vascular permeability. A general examination revealed symptoms of cardiac failure and multiple lymphadenopathies. Malignant hypertension with acute glomerulonephritis was diagnosed after a renal biopsy. After antihypertensive treatment, his blood pressure (BP) improved, and the SRD and choroidopathy promptly resolved. Presently, the patient is being followed up without complications. We report a case of hypertensive choroidopathy in a patient with CD associated with malignant hypertension. As a severe elevation in BP can damage choroidal vasculature and lead to vision loss, careful observation and active treatment are necessary.

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“…In addition to optic disk edema, Roth's spot was observed in the present case on fundus examination. Roth's spot can be observed in a variety of diseases but is rarely observed in patients with MCD [31], and it could be one of the ophthalmological manifestations of TAFRO syndrome.…”

Section: Discussionmentioning

confidence: 99%

Severe refractory TAFRO syndrome requiring continuous renal replacement therapy complicated with Trichosporon asahii infection in the lungs and myocardial infarction: an autopsy case report and literature review

et al. 2018

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Background: TAFRO (thrombocytopenia, anasarca, fever, reticulin myelofibrosis/renal failure, and organomegaly) syndrome is a systemic inflammatory disorder and unique clinicopathological variant of idiopathic multicentric Castleman disease that was proposed in Japan. Prompt diagnosis is critical because TAFRO syndrome is a progressive and life threating disease. Some cases are refractory to immunosuppressive treatments. Renal impairment is frequently observed in patients with TAFRO syndrome, and some severe cases require hemodialysis. Histological evaluation is important to understand the pathophysiology of TAFRO syndrome. However, systemic histopathological evaluation through autopsy in TAFRO syndrome has been rarely reported previously. Case presentation: A 46-year-old Japanese man with chief complaints of fever and abdominal distension was diagnosed with TAFRO syndrome through imaging studies, laboratory findings, and pathological findings on cervical lymph node and bone marrow biopsies. Interleukin (IL)-6 and vascular endothelial growth factor (VEGF) levels were remarkably elevated in both blood and ascites. Methylprednisolone (mPSL) pulse therapy was initiated on day 10, followed by combination therapy with PSL and cyclosporine A. However, the amount of ascites did not respond to the treatment. The patient became anuric, and continuous renal replacement therapy was initiated from day 50. However, the patient suddenly experienced cardiac arrest associated with myocardial infarction (MI) on the same day. Although the emergent percutaneous coronary intervention was successfully performed, the patient died on day 52, despite intensive care. Autopsy was performed to ascertain the cause of MI and to identify the histopathological characteristics of TAFRO syndrome.(Continued on next page)

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Retinal vein occlusion during flare of multicentric Castleman's disease

Cited by 6 publications

References 11 publications

Bartonella henselae Neuroretinitis: A Rare Coinfection in POEMS Syndrome

Bartonella henselae Neuroretinitis: A Rare Coinfection in POEMS Syndrome

Idiopathic Multicentric Castleman Disease Presenting With Hypertensive Choroidopathy: A Case Report

Severe refractory TAFRO syndrome requiring continuous renal replacement therapy complicated with Trichosporon asahii infection in the lungs and myocardial infarction: an autopsy case report and literature review

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