Retinal Vein Occlusion Following Two Doses of mRNA-1237 (Moderna) Immunization for SARS-Cov-2: A Case Report

Abstract

Introduction Published data on possible ocular adverse events potentially associated with vaccination with the SARS-Cov-2 mRNA-1237 vaccine are scarce. In this report, we describe the case of a patient who had a hemispheric retinal vein occlusion potentially associated with being vaccinated with the second dose of the SARS-Cov-2 mRNA-1237 vaccine. Methods Case report including a discussion on multimodal imaging. Results A 74-year-old woman presented with painless vision loss in the right eye experienced 48 hours after receiving a second dose of the mRNA-1237 vaccine. The patient was receiving oral anticoagulant therapy for atrial fibrillation. Her best-corrected visual acuity (VA) was 20/32, and fundus examination showed venous congestion and widespread blot haemorrhages in the inferior quadrants. Based on multimodal imaging evaluation, the diagnosis of hemispheric retinal vein occlusion was made. Due to the development of cystoid macular oedema with intraretinal fluid and the decline in VA, the patient was treated with two injections of intravitreal ranibizumab, leading to functional improvement and regression of oedema. Conclusions We report a case with retinal vein occlusion 48 hours after vaccination with the SARS-Cov-2 mRNA-1237 vaccine; however, the relationship between these two events remains unclear. Further research is warranted to better understand the potential link between retinal thrombotic events and vaccination.

Retinal artery/vein occlusion complicating SARS-CoV-2 vaccinations

“…The authors did not include several reports published before the 10 th January 2022 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 . It should be explained why these cases were not included in the review.…”

Bilateral Branch Retinal Vein Occlusion after mRNA-SARS-CoV-2 Booster Dose Vaccination

“…In the literature, a few case reports of unilateral RVO after COVID-19 vaccination have been reported [ 2 , 3 , 4 , 5 ]. Nonetheless, one of these depicted a concomitant central retinal artery and vein occlusion after the second dose [ 6 ].…”

Central Retinal Vein Occlusion in a Young Woman with Diabetes and Hypertension after mRNA-Based COVID-19 Vaccination—A Case Report and Brief Review of the Literature

“…According to previous reports, the side effects of the vaccine do not necessarily occur after the first dose. A total of 22 of the 51 cases from the published reports presented with RVO after the 2nd dose of the vaccination [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. There was 1 case which showed symptoms appearing 25 days after receiving the 3rd dose of AZD1222 [ 29 ].…”