Retinal Vessel Density in Exudative and Nonexudative Age-Related Macular Degeneration on Optical Coherence Tomography Angiography

Lee, Sophie C.; Tran, Steven; Amin, Aana; Morse, Lawrence S.; Moshiri, Ala; Park, Susanna S.; Yiu, Glenn

doi:10.1016/j.ajo.2019.11.031

Cited by 35 publications

(26 citation statements)

References 41 publications

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“…Furthermore, OCTA can reveal the retinal vascular structure layer by layer, which provides micromesh information about structural damage ( 11 ). Combined with structural optical coherence tomography ( 12 ), OCTA enables a more comprehensive understanding of vascular abnormalities in some eye diseases, including diabetic retinopathy ( 13 ), glaucoma ( 14 , 15 ), age-related macular degeneration ( 16 ), retinal vein obstruction ( 17 , 18 ), and Vogt-Koyanagi-Harada disease ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Yan

Hou

et al. 2021

Front. Med.

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Purpose: To investigate the involvement of peripapillary zone vascular abnormalities in Behcet's uveitis (BU) and associated visual dysfunction. We evaluated the retinal and choroidal microvascular features in both macular and peripapillary areas of BU patients to identify vascular abnormalities contributing to reduced best-corrected visual acuity (BCVA) using optical coherence tomography angiography (OCTA).Methods: A prospective, observational study was conducted in 24 eyes of 13 patients with BU and 24 eyes of 15 healthy participants as controls. They received a standard eye examination and were recorded by OCTA measurements of macular and peripapillary areas. The vascular densities of superficial capillary plexus (SCP) and deep capillary plexus (DCP), choroidal flow area, radial peripapillary capillary network (RPCN) density, foveal avascular zone (FAZ) area and perimeter, full retinal thickness (FRT), and peripapillary retinal nerve fiber layer thickness (pRNFLT) were measured.Correlations among microvascular, structural, and functional changes were assessed.Results: Our findings uncovered that the vascular density was significantly reduced in the peripapillary zone of BU eyes compared to healthy eyes, especially in the inferior subfield of the RPCN. The vascular densities of SCP and DCP quadrants within the macular zone had no significant difference between BU and control groups except for DCP density of the nasal parafoveal quadrant. Both FAZ area and perimeter were greater but without statistical significance in the BU group. Compared to healthy eyes, the choriocapillaris flow area was smaller while the FRT and pRNFLT were greater in the BU group. Notably, there was a significant correlation between the reduction in RPCN vascular density and decreased BCVA in BU patients.Conclusion: Based on OCTA, vascular changes associated with BU are more prominent in the peripapillary zone than those in the macular zone. The vascular density of the RPCN could serve as a sensitive indicator to monitoring BU pathogenic progression and treatment response using a non-invasively method of OCTA.

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Section: Introductionmentioning

confidence: 99%

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Yan

Hou

et al. 2021

Front. Med.

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“…However, the impact of the retinal vasculature on advanced stages of ARMD remains unclear. More recently, Lee et al found that CVD in the SCP is reduced in eyes with eARMD as compared to neARMD ( 22 ). They found no differences in FAZ area, perimeter, or circularity between eARMD and neARMD groups.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Retinal Vessel Density and Foveal Avascular Zone in Unilateral Exudative Choroidal Neovascularization by Optical Coherence Tomography Angiography

Çan¹

2022

Beyoglu Eye J

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Objectives: To evaluate treatment-naïve patients with neovascular-exudative age-related macular degeneration (eARMD) in one eye and early-/intermediate-stage nonexudative ARMD (neARMD) in the fellow eye by optical coherence tomography-angiography (OCTA). Methods: A total of 70 eyes of 35 patients (17 females) with first diagnosis of eARMD in one eye and early/intermediate-stage neARMD in the fellow eye were included in this study. The eARMD diagnosis was confirmed by fluorescein angiography. Each subject underwent OCTA imaging by RTVue XR Avanti OCT device. Capillary vessel density (VD) of superficial (SCP) and deep (DCP) retinal capillary plexuses and foveal avascular zone (FAZ) parameters were measured. Results: The mean age was 72.0±8.9 years (range 59–87). The mean visual acuity was 0.7±0.5 logMar for the eARMD eyes and 0.4±0.3 logMar for the fellow eyes (p=0.012). Nineteen patients (54.3%) had occult choroidal neovascularization (CNV), and 16 patients (45.7%) had classical CNV. The mean FAZ area was measured 0.30 ± 0.11 mm 2 in the eARMD eyes and 0.27±0.11 mm 2 in the fellow eyes (p=0.387). The FAZ circularity index measurement was 1.15±0.03 in eARMD eyes and 1.11±0.05 in the fellow eyes (p=0.014). There was no statistically significant difference in any measure of the macular SCP and DCP’s VD between eARMD eyes and their fellow eyes. Conclusion: Potential retinal vascular alterations will be important in ARMD pathogenesis.

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“…8,58,59 Thus our data suggests both localized and global impact on lipofuscin distribution in eyes with drusen and AMD in primate species. As the pathogenesis of AMD is complex and multifactorial, including oxidative stress, 60 lipid accumulation, 61,62 immune dysregulation, 63,64 and vascular changes, 65,66 the role of lipofuscin accumulation among these factors remains unclear. Future biochemical measurements and more robust histological correlations may help further explore the relationship between qAF signal, lipofuscin accumulation, and soft drusen biogenesis in rhesus macaques.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Fundus Autofluorescence in Rhesus Macaques in Aging and Age-Related Drusen

Tran

Kim

Lin

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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To employ quantitative fundus autofluorescence (qAF) imaging in rhesus macaques to noninvasively assess retinal pigment epithelial (RPE) lipofuscin in nonhuman primates (NHPs) as a model of aging and age-related macular degeneration (AMD). METHODS. The qAF imaging was performed on eyes of 26 rhesus macaques (mean age 18.8 ± 8.2 years, range 4-27 years) with normal-appearing fundus or with age-related soft drusen using a confocal scanning laser ophthalmoscope with 488 nm excitation and an internal fluorescence reference. Eyes with soft drusen also underwent spectraldomain optical coherence tomography imaging to measure drusen volume and height of individual drusen lesions. The qAF levels were measured from the perifoveal annular ring (quantitative autofluorescence 8 [qAF8]) using the Delori grid, as well as focally over individual drusen lesions in this region. The association between qAF levels and age, sex, and drusen presence and volume were determined using multivariable regression analysis. RESULTS. Mean qAF levels increased with age (P < 0.001) and were higher in females (P = 0.047). Eyes with soft drusen exhibited reduced mean qAF compared with agematched normal eyes (P = 0.003), with greater drusen volume showing a trend toward decreased qAF levels. However, qAF levels are focally increased over most individual drusen (P < 0.001), with larger drusen appearing more hyperautofluorescent (R 2 = 0.391, P < 0.001). CONCLUSIONS. In rhesus macaques, qAF levels are increased with age and female sex, but decreased in eyes with soft drusen, similar to human AMD. However, drusen lesions appear hyperautofluorescent unlike those in humans, suggesting similarities and differences in RPE lipofuscin between humans and NHPs that may provide insight into drusen biogenesis and AMD pathogenesis.

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Retinal Vessel Density in Exudative and Nonexudative Age-Related Macular Degeneration on Optical Coherence Tomography Angiography

Cited by 35 publications

References 41 publications

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Evaluation of Retinal Vessel Density and Foveal Avascular Zone in Unilateral Exudative Choroidal Neovascularization by Optical Coherence Tomography Angiography

Quantitative Fundus Autofluorescence in Rhesus Macaques in Aging and Age-Related Drusen

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