Retinitis pigmentosa and retinal oedema.

Spalton, David J.; Bird, Alan C.; Cleary, Philip E.

doi:10.1136/bjo.62.3.174

Cited by 66 publications

(40 citation statements)

References 15 publications

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“…28 A previous study reported that macular oedema did not appear to be more common in any of the genetic groups. 29 Because of the small number of patients in our cohort within the various genetic subtypes of RP, we did not report a statistical analysis for the difference in the presence of CME between genetic subtypes.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of cystoid macular oedema on optical coherence tomography in retinitis pigmentosa patients without cystic changes on fundus examination

Hajali

Fishman

2008

Eye

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Purpose To determine the prevalence of cystoid macular oedema (CME) by optical coherence tomography (OCT) in retinitis pigmentosa (RP) patients with no evidence of cystic macular lesions on fundus examination. Methods We included 63 RP patients with no evidence of cystic-appearing macular changes on fundus examination. All patients underwent a complete ocular examination including best-corrected visual acuity using an ETDRS (Early Treatment Diabetic Retinopathy Study) chart, intraocular pressure measurement, anterior segment examination, and a detailed fundus examination. On 50 of the 63 patients, Fourier-domain OCT was performed using the radial slicer protocol. An additional 13 of the 63 patients were scanned using the macular thickness protocol on a time-domain OCT unit. The diagnosis of CME was defined by the presence of hyporeflective lacunae with well-defined boundaries on at least two of the scans. Results The mean age of patients included in the study was 36 years (range 9-71 years). Out of the 63 patients examined, 20 showed CME in at least one eye (32%), whereas 11 patients showed CME in both eyes (18%). Conclusions Our findings demonstrate that a substantial number of RP patients with CME, as determined by OCT, may not show cystic changes by direct ophthalmoscopy or contact lens biomicroscopy. Knowledge of the high frequency for CME in such patients can serve to identify those who may be amenable to current or future treatment strategies of their macular oedema and can potentially impact on future therapeutic trials where visual acuity is used as an outcome measure.

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Section: Discussionmentioning

confidence: 99%

The prevalence of cystoid macular oedema on optical coherence tomography in retinitis pigmentosa patients without cystic changes on fundus examination

Hajali

Fishman

2008

Eye

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“…Certain clinical observations suggest that retinal pigment epithelium may primarily or secondarily be involved in retinitis pigmentosa (Flannery et al 1989;Spalton et al 1978). Most recently, defects in proteins associated with RPE have been identified (Petrukhin et al 1998;Maw et al 1997;Gu et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Dissection and cotransplantation of large pieces of RPE and neural retina; effect of protease K on the development

Sharma

2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: This study attempts to cotransplant large pieces of the RPE and neural retina in the subretinal space of rabbits by using protease K for dissection of the donor tissue, and to investigate the effect of dissection technique on the development of the grafts. Methods: Eyes from 15-day-old pigmented rabbit embryos were partly digested by protease K to assist dissection of sclera and the choroid from RPE and neural retina. Large pieces of RPE and the neural retina thus obtained were cotransplanted into the eyes of adult albino rabbits who were allowed to survive for up to 63 days. The transplants were examined under light microscope. Results: It was possible to transplant large sheets of RPE and neural retina together. Both the RPE and the neural retina survived after cotransplantation. Retinal pigment epithelium survived in layers, but at places formed clusters. In cotransplants neural retina formed rosettes, developed gliosis, and photoreceptors failed to develop outer segments, possibly due to the action of protease K. Conclusion: Proteases seem to be injurious for the development of the neural retina.

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“…Apart from the general risks of cataract surgery, there are specific additional factors that may result in a poor visual outcome after cataract extraction in the presence of retinitis pigmentosa. These include, retinal atrophy at the macula, macular edema occurring in approximately 10-15% of patients and phototoxic retinal damage in normal patients undergoing cataract extraction (Grover et al, 1997;Spalton et al, 1978;Newsome, 1986;Lee and Sternberg, 1993). The threshold for light damage is probably lower in retinitis pigmentosa, which could adversely affect visual outcome.…”

Section: Retinitis Pigmentosamentioning

confidence: 99%

Cataract Surgery in Retina Patients

Örnek¹

2013

Cataract Surgery

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Retinitis pigmentosa and retinal oedema.

Cited by 66 publications

References 15 publications

The prevalence of cystoid macular oedema on optical coherence tomography in retinitis pigmentosa patients without cystic changes on fundus examination

The prevalence of cystoid macular oedema on optical coherence tomography in retinitis pigmentosa patients without cystic changes on fundus examination

Dissection and cotransplantation of large pieces of RPE and neural retina; effect of protease K on the development

Cataract Surgery in Retina Patients

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