Retinoblastoma in Onitsha, Nigeria

Nwosu, Snn; Okpala, Nonso E; Nnubia, Chinasa A; Akudinobi, Cyriacus U

doi:10.4103/njo.njo_20_18

Cited by 6 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our center, 10 cases of bilateral proptosis and 17 cases of unilateral proptosis were observed (Table 2 ). These findings are consistent with the patterns observed in other studies, suggesting that the most common modes of presentation at retinoblastoma centers in Nigeria are extraocular extension of retinoblastoma and proptosis [ 11 , 21 , 22 ].…”

Section: Discussionsupporting

confidence: 92%

“…The age range observed in our study (Table 1 ) is similar to certain regions within Nigeria, but differs from others. For instance, a study in the South-east [ 21 ] reported an age range of 5 months to 6 years, while a study in Lagos reported a range of 24.4 ± 11.4 months [ 22 ]. A mean age of 33.68 ± 12.27 months was reported in a study from the South-South region [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Presentation pattern and survival rate of retinoblastoma following chemotherapy: a prospective study

Atima,

Idakwo,

Komolafe

et al. 2023

BMC Pediatr

View full text Add to dashboard Cite

Background This study presents the clinical pattern of presentation and survival rate of retinoblastoma, which is the most prevalent form of pediatric intraocular cancer. The aim of this study is to provide baseline information about the clinical presentation and management of retinoblastoma at ECWA Eye Hospital. Additionally, the study identifies priority areas for enhancing medical care for children diagnosed with this cancer. ECWA Eye Hospital, situated in Kano State, Nigeria, is a specialized eye center located in the North-Western region of the country. Methods A prospective study spanning five years was conducted at ECWA Eye Hospital to investigate clinically diagnosed cases of retinoblastoma. The study took place from January 2018 to December 2022. The patients received standardized pre-medication and chemotherapy protocols for retinoblastoma. Subsequently, a five-year follow-up was conducted to monitor the patients’ progress. The collected data was analyzed, descriptive statistics were generated, and the survival rate was calculated. Results During the five-year study period, a total of 35 cases of retinoblastoma were diagnosed. The patients had an average age of 3.21 ± 1.32 years. The most common presentation patterns observed were fungating ocular mass and proptosis. Among the cases, there were 10 instances of bilateral proptosis and 25 instances of unilateral proptosis. While no patients exhibited bilateral leukocoria, eight cases of unilateral leukocoria with anterior segment seedlings were identified. The additional patterns of presentation are proptosis, leukocoria, fungating orbital mass, redness and loss of vision. The mortality rate was 80% (28 cases), while the survival rate was 20% (7 cases). Notably, all the survivors had unilateral retinoblastoma. Conclusion The majority of cases observed at ECWA Eye Hospital involve advanced retinoblastoma. In low-resource settings where alternative treatment options are limited, chemotherapy is considered a viable treatment option. Early presentation of retinoblastoma in patients may lead to a higher survival rate when chemotherapy is administered.

show abstract

Section: Discussionsupporting

confidence: 92%