Retinoblastoma: treatment and survival in Great Britain 1963 to 2002

MacCarthy, Angela; Birch, Jill; Draper, G J; Hungerford, J L; Kingston, J E; Kroll, M E; Stiller, Charles; Vincent, Tim; Murphy, Michael

doi:10.1136/bjo.2008.139626

Cited by 115 publications

(94 citation statements)

References 2 publications

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“…When the disease is diagnosed in its early intraocular stages, as is usually the case in developed countries, the probability of disease-free survival has been greater than 80-90% for decades [1,2]. These encouraging survival figures are not the result of the use of sophisticated treatments since enucleation of the affected eye, a simple surgical procedure, is usually curative in cases of intraocular retinoblastoma.…”

Section: Introductionmentioning

confidence: 94%

Strategies to manage retinoblastoma in developing countries

Chantada

Qaddoumi

Canturk³

et al. 2010

Pediatric Blood & Cancer

131

109

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Survival of retinoblastoma is >90% in developed countries but there are significant differences with developing countries in stage at presentation, available treatment options, family compliance, and survival. In low‐income countries (LICs), children present with advanced disease, and the reasons are socioeconomic and cultural. In middle‐income countries (MICs), survival rates are better (>70%), but there is a high prevalence of microscopically disseminated extraocular disease. Programs for eye preservation have been developed, but toxicity‐related mortality is higher. Although effective treatment of microscopically extraocular disease improved the outcome, worldwide survival will be increased only by earlier diagnosis and better treatment adherence. Pediatr Blood Cancer 2011;56:341–348. © 2010 Wiley‐Liss, Inc.

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Section: Introductionmentioning

confidence: 94%

Strategies to manage retinoblastoma in developing countries

Chantada

Qaddoumi

Canturk³

et al. 2010

Pediatric Blood & Cancer

131

109

View full text Add to dashboard Cite

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“…[7][8][9] Early diagnosis campaigns are probably the solution. [18,19] Parents should be taught to look for the presence of a red reflex of the eye by taking a flash photograph of their children younger than 1 year of age and to report the absence of this reflex, or the presence of any white spot in the eye, at the nearest primary care facility, which may improve early diagnosis. Healthcare workers also need training to increase their awareness that leucocoria in a young child is probably due to RB, and refer these patients urgently to a tertiary healthcare facility for further management.…”

Section: Discussionmentioning

confidence: 99%

Retinoblastoma outcome at a single institution in South Africa

et al. 2014

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“…More than 95% of affected children in industrialized countries survive, 1 and the most likely explanation for these excellent results is early diagnosis, which is determined by adequate access to health care and early consultation with specialists that lead to the detection of the disease well before it disseminates outside the eye. Metastatic retinoblastoma at presentation is, therefore, uncommon in the most developed countries, but it is still the major cause of mortality of retinoblastoma in less developed countries.…”

Section: Introductionmentioning

confidence: 99%

Successful treatment of metastatic retinoblastoma with high-dose chemotherapy and autologous stem cell rescue in South America

Palma

Sasso

Dufort

et al. 2011

Bone Marrow Transplant

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High-dose chemotherapy (HDC) followed by autologous stem cell rescue (ASCR) is the only curative treatment for metastatic retinoblastoma, but its feasibility in developing countries is unknown. We report 11 consecutive children (six unilateral) treated in three South-American middleincome countries with HDC-ASCR. One patient had metastatic retinoblastoma at diagnosis and the remaining ones had a metastatic relapse. Metastatic sites included BM ¼ 6, bone ¼ 4, orbit ¼ 5 and central nervous system (CNS) ¼ 4. All patients received induction with conventional chemotherapy achieving CR at a median of 5.7 months from the diagnosis of metastasis. Conditioning regimens included carboplatin and etoposide with thiotepa in six or with CY in four or melphalan in one patient. All patients engrafted after G-CSF-mobilized peripheral blood ASCR and no toxic deaths occurred. Two children received post-ASCR CNS radiotherapy. Seven children have disease-free survival (median follow-up 39 months). CNS relapse, isolated (n ¼ 3) or with systemic relapse (n ¼ 1), occurring at a median of 7 months after ASCT was the most common event. In the same period, five children with metastatic retinoblastoma did not qualify for HDC-ASCR and died. We conclude that HDC-ASCR is a feasible and effective treatment for children with metastatic retinoblastoma in middle-income countries.

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Retinoblastoma: treatment and survival in Great Britain 1963 to 2002

Abstract: Survival rates were already high at the start of the study period. They increased with changes in treatment regimens.

Cited by 115 publications

References 2 publications

Strategies to manage retinoblastoma in developing countries

Strategies to manage retinoblastoma in developing countries

Retinoblastoma outcome at a single institution in South Africa

Successful treatment of metastatic retinoblastoma with high-dose chemotherapy and autologous stem cell rescue in South America

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